Clinical Trials Directory

Trials / Conditions / Central Nervous System Diseases

Central Nervous System Diseases

154 registered clinical trials studyying Central Nervous System Diseases38 currently recruiting.

StatusTrialSponsorPhase
RecruitingStudy of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EG
NCT07326566
Black Diamond Therapeutics, Inc.Phase 2
Not Yet RecruitingSelective Activation of the Adrenomedullin Receptors in Migraine
NCT07451769
Danish Headache CenterN/A
Not Yet RecruitingLongitudinal Assessment of Protein Markers in the Cerebrospinal Fluid of Patients With Central Nervous System
NCT07313098
Imagine Institute
Not Yet RecruitingAmylin-Induced Migraine Attacks Without Aura
NCT07340788
Danish Headache CenterN/A
Not Yet RecruitingHypersensitivity to Amylin in Post-Traumatic Headache
NCT07340775
Danish Headache CenterN/A
Not Yet RecruitingGravity Stroke System for Recanalization of Large Vessel Occlusion Strokes
NCT07335185
Gravity Medical Technology, INCN/A
RecruitingInvestigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Im
NCT07288385
King Saud UniversityN/A
RecruitingSlowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
NCT07324330
University Hospital, BonnN/A
RecruitingCardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation
NCT06954610
Insel Gruppe AG, University Hospital Bern
Not Yet RecruitingSlow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
NCT06993142
Radboud University Medical CenterN/A
RecruitingClinical Evaluation of EEG Device for the Triage of Stroke Patients in the Ambulance
NCT06871969
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)N/A
RecruitingDeep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in P
NCT06303869
Jorge Gonzalez-MartinezN/A
Active Not RecruitingProgressive Advancements in Neurosurgery, Data and Analysis Database
NCT06835634
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RecruitingNG004 in Spinal Cord Injury Patients
NCT06817577
NovaGo Therapeutics AGPhase 1
Not Yet RecruitingDigital Diagnostics and Intervention Services for Parkinson's Disease
NCT06534177
University of Exeter
RecruitingRole of New High Resolution Ultrasonographic Modalities for Diagnosis of Fetal Nervous System Anomalies
NCT05778279
Woman's Health University Hospital, Egypt
RecruitingTSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System
NCT06467773
Tongji Hospital
RecruitingPost-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow i
NCT05892510
University of MelbournePhase 2 / Phase 3
RecruitingVideo Call Assisted Assessment of Acute Stroke
NCT06570681
University of Southern DenmarkN/A
RecruitingThe Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy
NCT06418698
Zhujiang Hospital
RecruitingMixed Reality and Virtual Reality Technology With Mirror Therapy for Stroke Rehabilitation
NCT05903235
Chang Gung Memorial HospitalN/A
CompletedGravity Stent-Retriever System For Reperfusion Of Large Vessel Occlusion Stroke Trial
NCT06249776
Gravity Medical Technology, INCN/A
RecruitingMulticentre RCT of Awake Versus Asleep Tractography Based DBS for ET
NCT05968976
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)N/A
Active Not RecruitingHealth, Functioning, Work, and Experiences of Social and Health Services of Persons With Stroke
NCT06575907
The Finnish Association of People with Physical Disabilities
RecruitingSlow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands
NCT06193252
Radboud University Medical CenterN/A
RecruitingSpinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
NCT05731986
Kessler FoundationN/A
RecruitingTolerance Study of Robotic-Assisted Virtual Reality Walking Rehabilitation for Non-Walking Stroke Patients
NCT06053619
University Hospital, LimogesN/A
UnknownSafety and Efficacy Evaluation of the Robotic Enhanced Error Training of Upper Limb Function in Post-stroke an
NCT06010823
Reuth Rehabilitation HospitalN/A
RecruitingComprehensive Management of High-risk PopuLatIon of Stroke Based on Social Network
NCT05963828
Changhai HospitalN/A
CompletedVideo-call Assisted Assessment of Acute Stroke in Addition to Stroke Severity Scales in a Prehospital Setting
NCT05737420
University of Southern DenmarkN/A
UnknownTranscutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury
NCT05852379
Possover International Medical Center AGN/A
WithdrawnStudy to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflamm
NCT05321498
Inmune Bio, Inc.Phase 2
RecruitingA Multi-domain Lifestyle Intervention Among Aged Community-residents in Zhejiang, China
NCT05886114
Zhejiang UniversityN/A
RecruitingStudy to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Deme
NCT06088121
Advanced Technology & CommunicationsN/A
RecruitingPRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute Stroke
NCT06121336
Ludwig-Maximilians - University of Munich
Active Not RecruitingA Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZ
NCT05738486
Eli Lilly and CompanyPhase 3
TerminatedAn Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease
NCT05522387
Inmune Bio, Inc.Phase 2
RecruitingThe Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)
NCT05725499
Kessler FoundationN/A
Not Yet RecruitingQUality Of Life and surviVAl in carDIac arreSt Patients
NCT04129073
Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
RecruitingA Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5
NCT05508789
Eli Lilly and CompanyPhase 3
CompletedGadopiclenol Pharmacokinetics, Safety and Efficacy in Children < 2 Years of Age
NCT05590884
GuerbetPhase 2
RecruitingStudy of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
NCT05386108
Stemline Therapeutics, Inc.Phase 1 / Phase 2
UnknownPropranolol on Post Stroke Immune Status and Infection
NCT05375240
Tianjin Medical University General HospitalPhase 2
CompletedUsing Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in Stroke Patie
NCT05086874
Xin Huang
RecruitingFor Patients With Ischemic Stroke, Clinically Study the Effectiveness and Safety of Butylphthalide.
NCT05068349
Qianfoshan HospitalPhase 4
UnknownNUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting
NCT05475769
Hospital Clínico Universitario de Valladolid
CompletedA Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation
NCT05318976
Inmune Bio, Inc.Phase 2
CompletedHarmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers
NCT05202223
Elizabeth K RhodusN/A
CompletedChinese Validation of the Simplified Evaluation of CONsciousness Disorders(SECONDs)
NCT05496985
Hangzhou Normal UniversityN/A
RecruitingTherapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion
NCT06633809
Sir Run Run Shaw Hospital
UnknownRole and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease
NCT04871464
Beijing Friendship HospitalPhase 4
UnknownTelerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL-RCT)
NCT04908241
University of British ColumbiaN/A
CompletedDiagnosic and Pronostic Values of Kappa and Lambda Free Light Chains in Central Nervous System Inflammatory Di
NCT05088473
Centre Hospitalier Universitaire de Nice
TerminatedPhase 1 ALKS 1140 in Healthy Adults
NCT05019105
Alkermes, Inc.Phase 1
TerminatedThe Onyx™ Trial For The Embolization Of The Middle Meningeal Artery For Chronic Subdural Hematoma
NCT04742920
University Hospital, MontpellierN/A
SuspendedRandomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia
NCT04912115
PharmaTher Inc.Phase 2
CompletedPilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems
NCT05080777
UConn HealthN/A
UnknownThe SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
NCT05007353
National University of SingaporeN/A
TerminatedAn Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
NCT04912856
Xenon Pharmaceuticals Inc.Phase 3
CompletedDigital Mirror Therapy With Uni- and Bilateral Mirror Visual Feedback After Stroke: Treatment Effects and EEG
NCT04813120
Chang Gung Memorial HospitalN/A
CompletedDopaminergic Therapy for Frontotemporal Dementia Patients
NCT04937452
I.R.C.C.S. Fondazione Santa LuciaPhase 2
TerminatedXEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy
NCT04639310
Xenon Pharmaceuticals Inc.Phase 3
CompletedSpinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke
NCT04512690
Lee Fisher, PhDN/A
UnknownDexmedetomidine for Prevention of Postoperative Delirium After Intracranial Operation for Brain Tumor
NCT04399343
Capital Medical UniversityPhase 4
RecruitingLocomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
NCT04460872
North Florida Foundation for Research and EducationPhase 2
CompletedA Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in
NCT05527288
Sinotau Pharmaceutical GroupN/A
WithdrawnValidation of the Efficacy and Usability of the BELK Orthosis Knee Module in a Neurological Setting (BELK@CCP)
NCT04173975
Casa di Cura Privata del Policlinico SpAN/A
UnknownIntensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease
NCT05452655
Fondazione Don Carlo Gnocchi OnlusN/A
CompletedA Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TR
NCT04640077
Eli Lilly and CompanyPhase 2
RecruitingTreating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Applicat
NCT03678194
Centre Hospitalier Charles Perrens, BordeauxN/A
Active Not RecruitingThe Personalized Parkinson Project De Novo Cohort
NCT04985539
Radboud University Medical Center
CompletedArm Boot Camp Study: Evaluation of a Program to Increase Upper Limb Recovery After Stroke
NCT04232163
University of British ColumbiaN/A
CompletedImpact Dexmedetomidine on Postoperative Delirium in Patients After Intracranial Operation for Brain Tumor
NCT04494828
Capital Medical UniversityPhase 4
CompletedMulti-mode Stroke Rehabilitation System: Development and Validation of Clinical Efficacy
NCT04441190
Chang Gung Memorial HospitalN/A
CompletedNeurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated Encephalopathy
NCT04467762
University of Rostock
CompletedRheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke
NCT04266639
Grethe AndersenN/A
CompletedTelerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke
NCT04265664
University of British ColumbiaN/A
UnknownCombined Analysis of Inflammatory Biomarkers for CNS Autoimmune Diseases Diagnostic
NCT05056740
Centre Hospitalier Universitaire de Nice
CompletedThe Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients
NCT04260035
Danish Headache CenterN/A
RecruitingBrain Connections for Arm Movement After Stroke
NCT04286516
VA Office of Research and DevelopmentN/A
CompletedAdjunctive Use of Fute (Flupentixol) in Multi-acting Receptor-targeted Antipsychotics Treated Schizophrenia Pa
NCT04898270
Taichung Veterans General HospitalPhase 4
CompletedPredictors of Response in Chronic Stroke
NCT04283253
VA Pittsburgh Healthcare SystemN/A
CompletedpRESET for Occlusive Stroke Treatment
NCT03994822
phenox Inc.N/A
RecruitingHSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
NCT03911388
M.D. Anderson Cancer CenterPhase 1
WithdrawnComparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function
NCT04043715
University of WashingtonN/A
CompletedA Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With
NCT04445831
AC Immune SAPhase 1 / Phase 2
TerminatedPredicting Migraine Attacks Based on Environmental and Behavioral Changes as Detected From the Smartphone
NCT03762902
Lifegraph Ltd.
CompletedPower Training Combined With Interval Treadmill Training
NCT03625570
Louisiana State University Health Sciences Center in New OrleansN/A
CompletedCost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation
NCT03819764
The Cleveland ClinicN/A
CompletedFluoxetine Opens Window to Improve Motor Recovery After Stroke
NCT03448159
University Health Network, TorontoPhase 2
CompletedEvaluation of Safety and Efficacy of ProHance in Pediatric Patients <2yrs
NCT03750188
Bracco Diagnostics, Inc
UnknownHigh Dose Omega 3 in People at Risk for Dementia
NCT03926351
University Hospital, AkershusPhase 2
CompletedLong-term Telerehabilitation for Patients With Stroke
NCT03460587
University of California, IrvineN/A
UnknownVenezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine
NCT03776994
SRI InternationalPhase 1
CompletedHuman Epilepsy Project 2: Resistant Focal Seizures Study
NCT03531008
Epilepsy Foundation of America
CompletedCKD-355 Drug-drug Interaction Study (CKD-355 DDI P1)
NCT03569579
Chong Kun Dang PharmaceuticalPhase 1
CompletedRemote Ischemic Conditioning in Patients With Acute Stroke (RESIST)
NCT03481777
Grethe AndersenN/A
CompletedVentriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten
NCT05204745
Umeå University
CompletedMindfulness-based Intervention to Promote Psychological Wellbeing in People With Epilepsy
NCT04313686
University of MalayaN/A
UnknownThe Technology-assisted, High Intensive, Task-oriented Exercise Trial
NCT03396939
Sunnaas Rehabilitation HospitalN/A
CompletedThe Third, Intensive Care Bundle With Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial
NCT03209258
The George Institute for Global Health, ChinaN/A
CompletedIs Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches
NCT03512977
Derince Training and Research HospitalN/A
TerminatedEffect of the Visual Information Change in Functional Dystonia
NCT03270189
Fondation Ophtalmologique Adolphe de RothschildN/A
CompletedAMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)
NCT03127514
Amylyx Pharmaceuticals Inc.Phase 2
UnknownThe Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory
NCT02006615
Taipei Veterans General Hospital, TaiwanN/A
CompletedRetrospective Study of MRI With MULTIHANCE at 0.10 and 0.05 mmol/Kg Dose in CNS Patients
NCT03147989
Bracco Diagnostics, Inc
CompletedSafety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease
NCT03065192
Neurocrine BiosciencesPhase 1
TerminatedTestosterone Plus Finasteride Treatment After Spinal Cord Injury
NCT02248701
VA Office of Research and DevelopmentPhase 2
CompletedIntelligent Activity-based Client-centred Training
NCT02982811
PXL University CollegeN/A
UnknownThe SaeboGlove Evaluation Trial
NCT03036033
NHS Greater Glasgow and ClydeN/A
CompletedLong Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness
NCT03008486
Géraldine MartensPhase 2
CompletedIndividualized Prediction of Migraine Attacks Using a Mobile Phone App and Fitbit
NCT02910921
Second Opinion Health
CompletedStroke Rehabilitation With Exoskeleton-assisted Gait.
NCT03395717
IRCCS San Raffaele RomaN/A
CompletedNovel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity
NCT03020433
The Cleveland ClinicEARLY_Phase 1
CompletedPilot Study Concerning an Intelligent Activity-based Client-centred Training System in Neurorehabilitation
NCT04692311
PXL University CollegeN/A
CompletedGeneral Anesthesia for Endovascular Thrombectomy; A Pilot Study.
NCT02639806
University of Saskatchewan
TerminatedNatural History Study of Children With Metachromatic Leukodystrophy
NCT01963650
Shire
CompletedDetection of Silent Atrial Fibrillation aFter Ischemic StrOke
NCT02684825
Danilo ToniN/A
CompletedCNS Tau Kinetics in Healthy Aging and Alzheimer's Disease
NCT03938870
Washington University School of Medicine
CompletedReliability of the Melbourne Assessment
NCT02595411
University Children's Hospital, Zurich
CompletedStimulation With Wire Leads to Restore Cough
NCT01659541
MetroHealth Medical CenterN/A
Completed1H Magnetic Resonance Spectroscopy in Migraine Patients
NCT04220606
Leiden University Medical CenterN/A
Active Not RecruitingMobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower)
NCT02696603
Sage BionetworksN/A
CompletedA Multicentre Clinical Investigation of a Decision Support Algorithm for Neonatal Seizure Detection
NCT02431780
University College CorkN/A
CompletedFeasibility of the Portable YouGrabber System
NCT02368223
University Children's Hospital, ZurichN/A
CompletedThe Effect of Craniosacral Therapy as Additive Procedure.
NCT05722756
Wroclaw Medical University
CompletedPrecision Medicine in Stroke
NCT05815836
Ludwig-Maximilians - University of Munich
CompletedDetermining Optimal Post-Stroke Exercise (DOSE)
NCT01915368
University of British ColumbiaN/A
CompletedEfficacy of End-Effector Robot-Assisted Gait Training in Subacute Stroke Patients
NCT03805009
IRCCS San Raffaele RomaN/A
UnknownThe Long-Term Safety and Efficacy Follow-Up Study of Subjects Who Completed the Phase I Clinical Trial of Neur
NCT01696591
Duk Lyul Na
CompletedA Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers
NCT01495390
Massachusetts General Hospital
CompletedDexmedetomidine in Patients After Intracranial Surgery
NCT01445639
Capital Medical UniversityPhase 4
CompletedGORE Flow Reversal System and GORE Embolic Filter Extension Study
NCT01343667
W.L.Gore & AssociatesN/A
CompletedEffect of Undenatured Cysteine-Rich Whey Protein Isolate (HMS 90®) in Patients With Parkinson's Disease
NCT01662414
Chulalongkorn UniversityPhase 4
CompletedSafety and Efficacy Evaluation of DOTAREM® in MRI of Central Nervous System (CNS) Lesions
NCT01211873
GuerbetPhase 3
CompletedClinical Trial of Brain-Penetrating HIV Drugs to Prevent Cognitive Impairment in China
NCT01340950
University of California, San DiegoPhase 4
CompletedSafety and Cognitive Function Study of EVP-6124 in Patients With Mild to Moderate Alzheimer's Disease
NCT01073228
FORUM Pharmaceuticals IncPhase 2
UnknownInfluence of Physical Exercise on Cognitive Functioning of Traumatic Brain Injury Patients
NCT01395472
Federal University of São PauloN/A
CompletedVascular Risk Factors in INPH-patients
NCT01850914
Umeå University
CompletedSafety and Cognitive Function Study of EVP-6124 in Patients With Schizophrenia
NCT00968851
FORUM Pharmaceuticals IncPhase 2
CompletedSub-study to Spinal Cord Stimulation to Restore Cough
NCT00995215
MetroHealth Medical CenterN/A
CompletedDNX-2401 (Formerly Known as Delta-24-RGD-4C) for Recurrent Malignant Gliomas
NCT00805376
DNAtrix, Inc.Phase 1
CompletedClinical Evaluation of Swallowing Disorders as a Predictor of Extubation Failure
NCT00780078
Assistance Publique - Hôpitaux de Paris
CompletedSafety, Tolerability, and Pharmacokinetic Study of EVP-6124 in Patients With Alzheimer's Disease
NCT00766363
FORUM Pharmaceuticals IncPhase 1
CompletedSafety and Efficacy of Gadobutrol 1.0 Molar (Gadavist) in Patients for Central Nervous System (CNS) Imaging
NCT00709852
BayerPhase 3
CompletedSafety, Tolerability, and Pharmacokinetic Study of EVP-6124 in Patients With Schizophrenia
NCT01556763
FORUM Pharmaceuticals IncPhase 1
CompletedA Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Pat
NCT00649207
AbbVie (prior sponsor, Abbott)Phase 1
CompletedSafety and Efficacy of Gadobutrol 1.0 Molar ( Gadavist ) in Patients for Central Nervous System (CNS) Imaging
NCT00623467
BayerPhase 3
CompletedFollow Up Safety Study of SCH 420814 in Subjects With Parkinson's Disease (P05175)
NCT00537017
Merck Sharp & Dohme LLCPhase 2
CompletedDyskinesia in Parkinson's Disease (Study P04501)
NCT00406029
Merck Sharp & Dohme LLCPhase 2
CompletedEfficacy and Safety Study to Evaluate Gadavist (Gadobutrol) as Contrast Agent in Magnetic Resonance Imaging (M
NCT00395460
BayerPhase 3
TerminatedSafety and Efficacy of MultiHance in Pediatric Patients
NCT00323310
Bracco Diagnostics, IncPhase 3
CompletedCentral Nervous System Disease in HIV-infected Children on HAART
NCT00110331
National Cancer Institute (NCI)
CompletedSpinal Cord Stimulation to Restore Cough
NCT00116337
MetroHealth Medical CenterN/A