NCT05088473

Diagnosic and Pronostic Values of Kappa and Lambda Free Light Chains in Central Nervous System Inflammatory Diseases

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,500 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Numerous studies have shown the diagnostic interest of cerebrospinal fluid kappa free light chains and kappa index in multiple sclerosis. However, large cohort studies are lacking and little is known about the correlation between kappa and lambda indexes and multiple sclerosis evidence disease activity. Therefore, this study plan to validate the kappa and lambda free light chains and indexes as diagnostic biomarker in multiple sclerosis and to correlate the concentration of kappa and lambda free light chains with clinical and radiological activity in a large cohort of patients.

Conditions

• Central Nervous System Diseases
• Multiple Sclerosis

Interventions

Type	Name	Description
OTHER	Biological collection	Collection of cerebrospinal fluid kappa and lambda free light chains and indexes

Timeline

• Start date: 2021-10-15
• Primary completion: 2021-10-31
• Completion: 2021-10-31
• First posted: 2021-10-22
• Last updated: 2021-11-09

Locations

14 sites across 1 country: France