NCT06633809

Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion

Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion: A Prospective Multicenter Registry Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Sir Run Run Shaw Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy evaluation and prognostic prediction of the LVO patients with low NIHSS.

Detailed description

It was reported that about two third of the stoke patients might present with minor or mild stroke symptoms. 20-40% of those minor stroke patients had large vessel occlusion (LVO). AIS patients with LVO and low NIHSS are common and has been associated with early neurological deterioration and worse outcomes. Until now, the best therapy strategy for the acute stoke patients with minor stroke and large vessel occlusion is unknown. Thus, we sought to (1) explore the potential predictors of acute neurological deterioration and 90-day clinical outcome; (2) and evaluate the best therapy strategy.

Conditions

• Stroke, Acute
• Cerebrovascular Disorders
• Brain Diseases
• Central Nervous System Diseases
• Vascular Diseases
• Brain Infarction
• Nervous System Diseases

Interventions

Type	Name	Description
OTHER	Immediate endovascular therapy	The best medical therapy includes intravenous fibrinolysis, anticoagulants or antiplatelet, but NOT any immediate endovascular therapies.

Timeline

• Start date: 2021-11-22
• Primary completion: 2026-12-31
• Completion: 2027-03-01
• First posted: 2024-10-09
• Last updated: 2024-10-09

Locations

1 site across 1 country: China