Trials / Completed
CompletedNCT04220606
1H Magnetic Resonance Spectroscopy in Migraine Patients
Glutamate Concentrations in the Brain Over the Course of a Migraine-like Attack
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 39 (actual)
- Sponsor
- Leiden University Medical Center · Academic / Other
- Sex
- Female
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Accepted
Summary
To investigate the glutaminergic system in the onset of migraine-like attacks.
Detailed description
Glyceryl trinitrate infusion (GTN) is used to provoke migraine-like attacks in female migraine without aura patients. Apart from migraine without aura patients healthy female controls are also included as a control group. Over the course of a single day these females (migraineurs and healthy controls) were scanned three times on fixed time slots: before GTN infusion (baseline), 90 minutes and 270 minutes after start of GTN infusion. Scans are acquired on a 7 tesla scanner (Philips, Cleveland, USA) on software release 3 using a 32 channel receive array using single-volume proton magnetic resonance spectroscopy (1H MRS) with a volume of interest in the visual cortex glutamate, in which glutamate, GABA and other metabolites will be assessed. The primary endpoint; glutamate level changes towards the pre-ictal and ictal state with other metabolite (e.g. glutamine and GABA) changes as secondary endpoints.
Conditions
- Migraine Disorders
- Migraine Without Aura
- Headache Disorders, Primary
- Headache Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Glyceryl trinitrate (I.V. infusion 0.5 µg/kg/min over 20 min) |
Timeline
- Start date
- 2015-04-01
- Primary completion
- 2016-04-01
- Completion
- 2016-04-01
- First posted
- 2020-01-07
- Last updated
- 2020-01-07
Source: ClinicalTrials.gov record NCT04220606. Inclusion in this directory is not an endorsement.