| Recruiting | Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine NCT06716489 | University of Sao Paulo | N/A |
| Recruiting | MIGRAFIT: Evaluating a Group Therapy Program Combining Physical Activity, Progressive Muscle Relaxation and Ps NCT07419607 | Medical University Innsbruck | N/A |
| Not Yet Recruiting | Amylin-Induced Migraine Attacks Without Aura NCT07340788 | Danish Headache Center | N/A |
| Not Yet Recruiting | Hypersensitivity to Amylin in Post-Traumatic Headache NCT07340775 | Danish Headache Center | N/A |
| Recruiting | PERSONOLOGICAL STRUCTURE, COGNITIVE FUNCTIONS AND CENTRAL SENSITIZATION IN HEADACHE NCT07268768 | IRCCS Centro Neurolesi Bonino Pulejo | — |
| Recruiting | Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single NCT07307508 | Hamad Medical Corporation | N/A |
| Not Yet Recruiting | Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood NCT07033520 | Fundación Cardiovascular de Colombia | N/A |
| Not Yet Recruiting | Prevalence and Pattern of Headache in Pediatric Epilepsy NCT06868251 | Assiut University | — |
| Not Yet Recruiting | Can a Specific OMT Protocol Influence Patient Pain and Associated Analgesia Use for Primary Headache Disorders NCT06546462 | New York Institute of Technology | N/A |
| Recruiting | New Methods for Evaluating Preventive Migraine Treatment NCT07071506 | University of Aarhus | N/A |
| Completed | Effect of Kinesio Taping Combined With Postural Correction on Improving Tension-Type Headache Among University NCT07411820 | Deraya University | N/A |
| Active Not Recruiting | Comparing Unilateral and Bilateral Proximal GONPRF in Migraine Treatment NCT06894121 | Ankara City Hospital Bilkent | N/A |
| Completed | Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Disability Question NCT04736654 | Gazi University | — |
| Unknown | Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial NCT06170281 | Stanford University | N/A |
| Unknown | Real-world Effectiveness and Tolerability of Triptans-Ditans-Gepants (TRIDIGEP) NCT06267664 | Hospital Clínico Universitario de Valladolid | — |
| Recruiting | Smartphone Use Restriction as Treatment of Primary Headache NCT06041997 | All India Institute of Medical Sciences | N/A |
| Recruiting | Responding With Evidence and Access for Childhood Headaches NCT05889624 | Children's Hospital Medical Center, Cincinnati | N/A |
| Completed | Trigeminal Ganglion RFT vs Maxillary/Mandibular PRF in the Treatment of Trigeminal Neuralgia NCT06366139 | Diskapi Teaching and Research Hospital | N/A |
| Unknown | InfluenCEF Study: Study on the Headache Associated With Influenza Infection NCT05704335 | Hospital Clínico Universitario de Valladolid | — |
| Unknown | Validity and Reliability of the Dutch HDI NCT05619354 | University Ghent | — |
| Completed | Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Impact Questionnair NCT04765501 | Gazi University | — |
| Completed | Sustained Natural Apophyseal Glide and Deep Friction Massage in Patients With Cervicogenic Headache NCT05404113 | Riphah International University | N/A |
| Recruiting | Determining the Utility of a Behavioral Intervention in Chronic Migraine NCT05415020 | Mayo Clinic | N/A |
| Completed | Fibromyalgia Syndrome on Patients With Chronic Migraine NCT05381012 | Istanbul University - Cerrahpasa | N/A |
| Completed | Impact of COVID-19 Pandemic on Headache Evaluations in the Pediatric Emergency Department NCT06295003 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | — |
| Unknown | NUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting NCT05475769 | Hospital Clínico Universitario de Valladolid | — |
| Completed | NLP Headache Speech (NLPH-SPEECH): a Cross-sectional Study on Natural Language Processing Analysing Spoken Mon NCT05204316 | University Hospital, Ghent | N/A |
| Recruiting | Idebenone for the Preventive Treatment of Migraine NCT04151472 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 3 |
| Unknown | Resting State Functional Connectivity in Cluster Headache NCT06206772 | IRCCS National Neurological Institute "C. Mondino" Foundation | — |
| Completed | An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache NCT05153876 | University Hospital, Ghent | — |
| Active Not Recruiting | Intervention for Sleep and Pain in Youth: a Randomized Controlled Trial NCT04936321 | Seattle Children's Hospital | N/A |
| Unknown | Test-Retest Reliability of the German Version of the Headache Disability Questionnaire (HDQ). NCT04877561 | Zurich University of Applied Sciences | — |
| Recruiting | Mind Body Balance for Pediatric Migraine NCT04715685 | Children's Hospital Medical Center, Cincinnati | N/A |
| Unknown | Effects of Multimodal Treatment of Headache in a Day Clinic Service NCT05111873 | University Medicine Greifswald | — |
| Completed | Propranolol for Pediatric Migraine: A Prospective Clinical Study NCT07180043 | Kayseri University | N/A |
| Completed | Smoking and Health Among University Students NCT06680570 | University of Yalova | — |
| Completed | Natural Language Processing for Headache Medicine NCT05377437 | University Hospital, Ghent | N/A |
| Terminated | Therapy for Migraine Prevention in Children 6-11 Years of Age NCT04050293 | Supernus Pharmaceuticals, Inc. | Phase 4 |
| Withdrawn | Capsaicin in Treatment of Rhinogenic Headache NCT03330639 | University of Nebraska | N/A |
| Completed | Validation of the TMD Pain Screener in a Specialized Headache Center NCT04193111 | Danish Headache Center | — |
| Unknown | Jaw Muscle Function in Patients With Tension-type Headache NCT04196127 | Danish Headache Center | — |
| Completed | Multiomics After Cold Pressor Test of People Who Are Unable to Have Headache NCT04220580 | Danish Headache Center | N/A |
| Completed | The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) on Headache, Cranial Hemodynamic NCT03989817 | Danish Headache Center | N/A |
| Terminated | Predicting Migraine Attacks Based on Environmental and Behavioral Changes as Detected From the Smartphone NCT03762902 | Lifegraph Ltd. | — |
| Unknown | Osteopathic Manipulative Treatment and Migraine Headaches NCT04976985 | St. Luke's Hospital, Pennsylvania | N/A |
| Completed | Day to Day Variation of Pressure Pain Threshold and Muscle Hardness NCT03632928 | Danish Headache Center | — |
| Unknown | Effectiveness of Osteopathic Manipulative Therapy in Paediatric Patients, With High Frequency Headache. NCT04080258 | Antonio Francesco Urbino | N/A |
| Completed | Assessment of Inflammation in Primary Headaches NCT04891848 | Kocaeli University | — |
| Completed | Assessing the Diagnostic Accuracy of an On-line Questionnaire for Diagnosis of Primary Headache Disorders NCT03304886 | Stanford University | — |
| Unknown | Can Targeted Education Impact the Current Standard of Care in Patients With Mild Traumatic Brain Injury? NCT03391583 | Unity Health Toronto | N/A |
| Unknown | Topical Bimatoprost in the Treatment of Migraine NCT03419715 | Manistee Partners | Phase 2 |
| Completed | Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches NCT03512977 | Derince Training and Research Hospital | N/A |
| Completed | Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow NCT03385174 | Danish Headache Center | N/A |
| Recruiting | RegistRare: a Retro-prospective Registry of Rare Primary Headaches in Italian Tertiary Headache Centres NCT03416114 | Silvia Benemei | — |
| Completed | Individualized Prediction of Migraine Attacks Using a Mobile Phone App and Fitbit NCT02910921 | Second Opinion Health | — |
| Completed | Intervention for Sleep and Pain in Youth NCT03137147 | Seattle Children's Hospital | N/A |
| Terminated | Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical T NCT02624661 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Completed | Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. NCT02662972 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Completed | 1H Magnetic Resonance Spectroscopy in Migraine Patients NCT04220606 | Leiden University Medical Center | N/A |
| Completed | Pharmacokinetic Study to Compare Two Formulations of Paracetamol NCT01767428 | GlaxoSmithKline | Phase 1 |
| Completed | Zolmitriptan Nasal Spray Versus Eletriptan in the Acute Treatment of Migraine NCT01276977 | California Medical Clinic for Headache | N/A |
| Completed | Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in Working Communities NCT00457496 | University of Turin, Italy | Phase 3 |
| Completed | Spinal Manipulation for Treatment of Chronic Headaches NCT00246350 | University of Western States | Phase 2 |
| Completed | Occipital Nerve Stimulation to Treat Chronic Headaches NCT00205894 | Boston Scientific Corporation | Phase 1 / Phase 2 |
| Completed | Acupuncture for the Treatment of Chronic Daily Headaches NCT00086021 | National Center for Complementary and Integrative Health (NCCIH) | N/A |