| Recruiting | Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothp NCT07068204 | Dr. Joachim Enax | N/A |
| Not Yet Recruiting | Efficacy of Solventum™ Vitrebond™ Pulp Protect Liner/Base Used as a Liner/Base Under Dental Restorations NCT07261137 | Solventum US LLC | N/A |
| Recruiting | Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients NCT07133919 | Çanakkale Onsekiz Mart University | N/A |
| Recruiting | Efficacy of a Chitosan Dressing in Pulpotomy of Immature Permanent Teeth NCT07323433 | Minia University | N/A |
| Not Yet Recruiting | 3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars NCT07091331 | Universidad Autonoma de Baja California | N/A |
| Not Yet Recruiting | Surface Caries Feature Study NCT07048444 | 3Shape A/S | — |
| Not Yet Recruiting | Orthodontic Treatment on Oral Microbiota and Salivary Proteins NCT06824493 | Xi'an Jiaotong University | — |
| Not Yet Recruiting | Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations NCT06882343 | Future University in Egypt | N/A |
| Recruiting | Caries Detection With Two Different Caries Detecting Devices NCT06152081 | Tufts University | N/A |
| Not Yet Recruiting | Caries-associated Saliva Biomarkers Among Different Races NCT06838182 | Cairo University | — |
| Not Yet Recruiting | Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic Patient NCT06701565 | Cairo University | — |
| Not Yet Recruiting | Artificial Intellegence Rivals Digital Bitewing in Detect Secondary Caries NCT06667986 | Cairo University | — |
| Completed | Effectiveness of a Nutritional Counseling Tool in Reducing the Amount and Frequency of Sugar Intake NCT06673342 | Loma Linda University | N/A |
| Active Not Recruiting | Clinical Evaluation of a New Dual-cure Universal Adhesive NCT06615544 | Ivoclar Vivadent AG | N/A |
| Not Yet Recruiting | Effect of Caries Conceptualizing and Residential University Life NCT06595589 | Sara Ibrahim Ahmed Hedia | — |
| Not Yet Recruiting | Partial Caries Removal in Permanent Molars Restored Using Giomer NCT06601972 | NewGiza University | N/A |
| Enrolling By Invitation | Evaluation of CAD/CAM Onlays Fabricated by Subtractive Versus Additive Digital Manufacturing Techniques. NCT05943782 | Ain Shams University | N/A |
| Recruiting | Comparison of the Treatment Outcomes of the Conventional Stainless Steel Crown Restorations and the Hall Techn NCT06597669 | Hue University of Medicine and Pharmacy | N/A |
| Not Yet Recruiting | KAP of Dental Practitioners Regarding CRA NCT05792215 | Cairo University | — |
| Not Yet Recruiting | Comparative Evaluation of Bioflx Crowns vs Stainless Steel Crowns NCT06396195 | Cairo University | N/A |
| Recruiting | Caries Prevalence, Experience and Risk Related Factors Among Early Middle-aged Patients Attending Cairo Univer NCT06365281 | Cairo University | — |
| Recruiting | Oral Health Education and Message Framing Effect on Oral Health Status of Refugees in Egypt NCT06649760 | Alexandria University | N/A |
| Not Yet Recruiting | Accuracy of ICCMS Versus Simplified Cariogram NCT06448884 | Kirolos Hisham Nadi Sedek | — |
| Active Not Recruiting | Evaluation of Different Cementation Materials Used in Prefabricated Pediatric Zirconia Crowns NCT06690229 | Aydin Adnan Menderes University | N/A |
| Not Yet Recruiting | Arresting Carious Lesions With Minimal Intervention Techniques NCT06388746 | National and Kapodistrian University of Athens | N/A |
| Unknown | Clinical Performance of an Alkasite-based Restorative Material NCT06317857 | Cairo University | N/A |
| Recruiting | Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clini NCT06453005 | C K S Teja Institute Of Dental Sciences & Research | N/A |
| Recruiting | Evaluation of Antimicrobial, Post Operative Pain of Cinnamon Extract Versus Sodium Hypochlorite Irrigant Follo NCT05860712 | Cairo University | N/A |
| Completed | The Impact of Sage Extract on GTS B and D Gene Expression in S. Mutans NCT06703554 | Cairo University | N/A |
| Active Not Recruiting | Extraction of the Compromised First Permanent Molars NCT06231823 | Ain Shams University | N/A |
| Recruiting | Effect of Er,Cr:YSGG Sub-Ablative Laser Irradiation on Fissure Caries Prevention in Permanent Molars NCT06826456 | Alexandria University | N/A |
| Completed | Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101 NCT06182267 | Colgate Palmolive | Phase 1 |
| Unknown | Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial. NCT06063239 | G. d'Annunzio University | N/A |
| Completed | Dental Practitioners KAP Regarding Caries Preventive Measures in Cairo and Riyadah NCT05792800 | Cairo University | — |
| Active Not Recruiting | Early Treatments for Preventing Occlusal Caries Lesions NCT05969756 | Hue University of Medicine and Pharmacy | N/A |
| Active Not Recruiting | Clinical Performance of Injectable Composite Resins in Class I Cavities NCT06192667 | Hacettepe University | N/A |
| Completed | Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia NCT06618209 | Marmara University | — |
| Completed | Anticariogenic Properties of Zamzam Water NCT06538532 | Al-Azhar University | N/A |
| Completed | Post-operative Sensitivity in Resin Composites NCT06242184 | Pakistan Institute of Medical Sciences | N/A |
| Unknown | Prevention of Caries in Head and Neck Cancer Survivors Who Underwent Radiotherapy NCT06308796 | University of Milan | N/A |
| Unknown | Clinical and Radiographical Evaluation of CAD-CAM Crowns With and Without Deep Margin Elevation NCT06114030 | University of Sharjah | N/A |
| Active Not Recruiting | Birth to Three - Cavity Free NCT05756413 | University of Iowa | N/A |
| Unknown | Comparative Evaluation of an Electrical Impedance Device Versus Digital Radiography in Estimation of Remaining NCT06162182 | Rawda Hesham Abd ElAziz | N/A |
| Unknown | Photobiomodulation on Major Salivary Glands in Children With Caries Activity NCT05546528 | University of Nove de Julho | N/A |
| Unknown | Diagnostic Ability of Near Infrared Transillumination Detecting Interproximal Caries as Compared to Convention NCT05362461 | University of Colorado, Denver | — |
| Completed | Non-invasive Caries Management: Clinical Study NCT04373356 | Western University, Canada | N/A |
| Completed | Clinical Performances of 3-different Tooth-colored Restorative Materials in Class-II Cavities NCT06211582 | Hacettepe University | N/A |
| Completed | Fluoride Caries-control Effectiveness/Feasibility in Children NCT06690008 | Universidad El Bosque, Bogotá | N/A |
| Completed | Assessment of The Oral Health Status of Children With Chronic Kidney Disease NCT06578832 | Marmara University | — |
| Completed | Near Infrared Technology for the Detection of Proximal Caries NCT05919576 | Marmara University | — |
| Unknown | Remineralizing Efficacy of Giomer Varnish vs. Fluoride Varnish in Management of White Spot Lesions in Adult Pa NCT05306691 | Cairo University | EARLY_Phase 1 |
| Unknown | Clinical Performance of Thermoviscous Bulk Fill Resin Composites in Comparison to Conventional Packable Bulk F NCT05276154 | Minia University | N/A |
| Completed | CATCH Healthy Smiles:An Elementary School Oral Health Intervention Trial NCT04632667 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Quantitative Evaluation of Aerosols Produced in the Dental Office NCT05988359 | Wroclaw Medical University | N/A |
| Unknown | Evaluation of Caries Prevention Based on Genetic Etiology and Risk. NCT05600517 | Umeå University | N/A |
| Unknown | Retention of a Flowable Resin-based Sealant With Two Types of Adhesives NCT04945382 | National University of San Marcos, Peru | N/A |
| Unknown | Caries Sealing Using Giomer and Glass Ionomer Cement With or Without Silver Diamine Fluoride NCT03872986 | Hacettepe University | N/A |
| Unknown | Clinical Performance of Advanced Self- Adhesivee Resin Composite Hybrid Restorations. NCT04790383 | Rawda Hesham Abd ElAziz | N/A |
| Unknown | Remineralization Efficacy of Gum Arabic Varnish. NCT04422860 | Cairo University | Phase 2 / Phase 3 |
| Withdrawn | Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - General NCT04104789 | Virginia Commonwealth University | Phase 2 |
| Completed | Clinical Performance of Chairside CAD/CAM Restorations NCT04279574 | Solventum US LLC | N/A |
| Withdrawn | Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics NCT04105985 | Virginia Commonwealth University | Phase 2 |
| Unknown | The Effect of Casein Phosphopeptide Amorphous Calcium Phosphate on Affected Dentine NCT04303767 | Hams Hamed Abdelrahman | Phase 2 |
| Completed | Clinical Evaluation of Silver Nanoparticles in Comparison to Silver Diamine Fluoride in Management of Deep Car NCT05231330 | Suez Canal University | N/A |
| Unknown | Effect of Trait Anxiety in Women on Oral Health Status and Oral Health Care-Seeking Behavior NCT04274855 | Ain Shams University | — |
| Terminated | Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Pediatric NCT03962634 | Virginia Commonwealth University | Phase 2 |
| Withdrawn | Microbial Sampling of Carious Dentin NCT04011605 | University of Utah | — |
| Recruiting | Ozone Application Before Fissure Sealants NCT04040920 | IRCCS Burlo Garofolo | N/A |
| Recruiting | CARDEC-PEL: Comparison of Two Methods of Caries Risk Assessment in Children NCT03969628 | Federal University of Pelotas | N/A |
| Completed | LifE Style, Nutrition and Oral Health in Care Givers (LENTO) NCT04003493 | University of Eastern Finland | N/A |
| Unknown | Accuracy Of Sopro-Life Camera In Comparison With ICDAS II For Detection Of Initial Caries NCT03586713 | Cairo University | N/A |
| Completed | Anterior Zirconia vs. Resin Strip Crowns NCT03889535 | The Hospital for Sick Children | N/A |
| Unknown | Evaluation of Oral Condition and the Effect of Dental Treatment on Physical Parameters of Athletes NCT04251858 | Universidade Metropolitana de Santos | N/A |
| Completed | Livionex on Reducing Plaque Accumulation and Improving Oral Health in Children NCT04368533 | University of California, San Francisco | Phase 1 |
| Completed | Antibacterial Effect and Clinical Performance of Chitosan Modified Glass Ionomer NCT04365270 | Ain Shams University | Phase 3 |
| Unknown | Clinical Evaluation of Bioactive Resin Sealants vs Conventional Sealants in Permanent Molars NCT03779893 | Cairo University | Phase 1 / Phase 2 |
| Completed | Are Dental Neglect and the Siblings Risk Factors in Children NCT04122508 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Unknown | Post-radiation Dental Disease Amongst Head and Neck Cancer Patients NCT03703648 | Belfast Health and Social Care Trust | — |
| Unknown | Effect of the Incoportation of Copper and Zinc Nanoparticles Into Dental Adhesives NCT03635138 | University of Chile | N/A |
| Unknown | Correlation Between Caries Experience in Primary Molars and First Permanent Molars NCT03671200 | Cairo University | — |
| Completed | Effectiveness of Er:YAG Pulse Therapy for Achieving Pre-emptive Dental Analgesia in Children NCT03412721 | Plovdiv Medical University | N/A |
| Unknown | Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients NCT03590977 | Cairo University | N/A |
| Completed | The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong NCT03694496 | The University of Hong Kong | N/A |
| Completed | Remineralization Effects of Hydroxyapatite Toothpaste NCT03681340 | Dr. Joachim Enax | N/A |
| Completed | Using a Mouthwash Containing Propolis, Clove Oil and Chlorhexidine to Improve the Caries Risk of High Risk Pat NCT03553628 | Moataz Gamal Ali Abdul-Maksoud Konsouh | N/A |
| Completed | Interactive Parent-Targeted Text Messaging in Pediatric Clinics to Reduce Caries Among Urban Children NCT03294590 | Boston University | N/A |
| Completed | Exploring the Relationship Among Dental Caries, Nutritional Habits and Peri-implantitis NCT04439877 | Universitat Internacional de Catalunya | — |
| Completed | Clinical Evaluation of ELS Versus ELS Extra Resin Composite NCT03306576 | Istanbul Medipol University Hospital | N/A |
| Completed | Management of Occlusal Dentinal Caries in Deciduous Molars NCT03552835 | Sneha D. Suwarnkar | N/A |
| Unknown | Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment NCT04342858 | The University of Hong Kong | Phase 2 |
| Completed | Effect of Lactobacillus Rhamnosus GG and Bifidobacterium Longum in Children Aged 3 to 5 Years of Villavicencio NCT03078179 | Cooperative University of Colombia | N/A |
| Completed | EVALUATION OF AN ALTERNATIVE TECHNIQUE FOR THE APPLICATION OF SODIUM FLUOROPHOSPHATE: A 2-YEARS DOUBLE-BLIND R NCT05810389 | University of Buenos Aires | Phase 4 |
| Unknown | Role of Aloe Vera Versus Fluoride Toothpaste in Changing High to Low Salivary Bacterial Count NCT03108313 | Cairo University | Phase 2 |
| Completed | Study of Oral Conditions in Indigenous Populations in the State of Roraima - Brazil NCT03660410 | Universidade Metropolitana de Santos | — |
| Unknown | The Effects of Stainless Steel Crowns Applied With Hall Technique on Occlusal Vertical Dimension NCT03010618 | Bezmialem Vakif University | N/A |
| Completed | Clinical Performance of Two Bulk-Fill Composite of Posterior Restorations NCT03230604 | Universidad Nacional Andres Bello | N/A |
| Unknown | Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits NCT02958891 | Medical Corps, Israel Defense Force | — |
| Completed | Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars NCT03119779 | Cairo University | N/A |
| Completed | Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans NCT03004196 | Peoples University, Bhanpur, Bhopal | Phase 1 / Phase 2 |
| Completed | Indirect Pulp Capping With Resin Modified Glass Ionomer NCT02494193 | Universidade Federal de Sergipe | N/A |
| Completed | Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi NCT02333227 | Baylor College of Medicine | N/A |
| Terminated | Clinical Trial Proximal Caries Infiltration and Detection NCT01796106 | DMG Dental Material Gesellschaft mbH | N/A |
| Completed | Clinical Evaluation of the Antibacterial Activity of Thioglycosides Extracted from White Mustard - Bamberka in NCT06908265 | Medical University of Warsaw | EARLY_Phase 1 |
| Completed | Comparing Hall vs Conventional Technique in Placing Preformed Metal Crowns From Sudan NCT03640013 | Khartoum Centre for Research and Medical Training | N/A |
| Completed | Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice NCT03761485 | Federal University of Paraíba | Phase 4 |
| Completed | Selective Dentine Removal in Primary Teeth NCT03872037 | Faculty Sao Leopoldo Mandic Campinas | N/A |
| Completed | Treatment of Immature Permanent Teeth With Three Different Pulp Capping Materials With Partial Pulpotomy NCT03426046 | Didem Sakaryali | Phase 4 |
| Completed | Fluoridated Milk and Enamel Caries in Adolescents NCT06684405 | Malmö University | N/A |
| Completed | Long-term Effects of a Lay Health Advisor Intervention on Immigrant Children's Caries NCT04562675 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Completed | Nano-hydroxyapatite and Ozone - Effect on Approximal Initial Caries NCT04147091 | Pomeranian Medical University Szczecin | Phase 2 / Phase 3 |
| Completed | Using Motivational Interviewing To Reduce Parental Risk-Related Behaviors For Early Childhood Caries NCT04286256 | University of Minnesota | N/A |
| Completed | Reducing Bacteria That Cause Tooth Decay NCT03062605 | University of California, Los Angeles | Phase 3 |
| Withdrawn | Alternative Treatment of Deep Carious Lesions Based on Biological Evidences NCT00973089 | Hadassah Medical Organization | N/A |
| Completed | Atraumatic Restorative Treatment Sealants in First Permanent Molars NCT03667768 | University of Sao Paulo | N/A |
| Completed | Salivary Bacteria and Oral Health Status in Children With ADHD NCT00966394 | Hadassah Medical Organization | — |
| Unknown | Caries in Adolescents (Karies Hos Ungdom) NCT05935813 | Kompetansesenteret Tannhelse Midt (TkMidt) | — |
| Completed | Prevention of Adult Caries Study (PACS) NCT00357877 | Tufts University | Phase 3 |
| Completed | Effectiveness of Pit and Fissure Sealants in the Prevention of Dental Caries NCT00674869 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | Prevention of Transmission of Bacteria That Cause Cavities From Mothers to Their Children NCT00066040 | New York University | N/A |
| Completed | Health Effects of Silver-Mercury Dental Fillings NCT00066118 | University of Washington | Phase 3 |