NCT07068204

Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)

Caries-preventing Effect of 2% Calcium Hypophosphite Toothpaste Compared to a Sodium Fluoride Toothpaste (1450ppm F) in Adults

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 164 (estimated)
• Sponsor: Dr. Joachim Enax · Industry
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.

Conditions

• Caries, Dental
• Calcium Hypophosphite
• Fluoridation

Interventions

Type	Name	Description
DEVICE	2% Calcium Hypophosphite Toothpaste	Oral hygiene instruction and regular application of the 2% Calcium Hypophosphite Toothpaste at home (twice daily over a period of 546 days, i.e., 18 months).
DEVICE	Sodium Fluoride Toothpaste (1450 ppm F)	Oral hygiene instruction and regular application of the Sodium Fluoride Toothpaste at home (twice daily over a period of 546 days, i.e., 18 months).

Timeline

• Start date: 2026-01-22
• Primary completion: 2027-12-01
• Completion: 2028-01-01
• First posted: 2025-07-16
• Last updated: 2026-04-13

Locations

2 sites across 1 country: Poland