NCT06824493

Orthodontic Treatment on Oral Microbiota and Salivary Proteins

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Xi'an Jiaotong University · Academic / Other
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: Accepted

Summary

Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.

Conditions

• Orthodontics
• White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
• Caries, Dental

Interventions

Type	Name	Description
OTHER	no interventions	no intervention as this is an observational studies
OTHER	None-placebo	Observational study with no interventions
OTHER	No Intervention: Observational Cohort	no intervention because of observational studies

Timeline

• Start date: 2025-07-01
• Primary completion: 2027-03-01
• Completion: 2027-09-01
• First posted: 2025-02-13
• Last updated: 2025-06-04