NCT04040920

Ozone Application Before Fissure Sealants

The Effect of Ozone Application Before Fissure Sealants: a Split Mouth Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 67 (estimated)
• Sponsor: IRCCS Burlo Garofolo · Academic / Other
• Sex: All
• Age: 6 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces. Decays generally evolve in fissures and pits of secondary molars. Pits and fissure sealants prevent decays if performed in two years from eruption. Ozone has bactericidal effect and remineralizing capacity on enamel. The aim of this study is to assess the effectiveness of ozone application before sealants in increasing their duration in time.

Conditions

• Caries,Dental

Interventions

Type	Name	Description
DEVICE	Ozone	One minute of pretreatment with ozone by using the OzoneDTA device
OTHER	Pits and fissure sealants	cleansing of the occlusal surfaces with a nylon brush and polishing toothpaste; surface etching with 36% orthophosphoric acid for 30'', surface cleaning and drying for 30 '', application of the sealing material, polymerization for 60'';

Timeline

• Start date: 2019-06-17
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2019-08-01
• Last updated: 2025-05-16

Locations

1 site across 1 country: Italy