| Not Yet Recruiting | Study of the Safety and Efficacy of DS010 in Patients With Cancer Cachexia NCT07530666 | Dartsbio Pharmaceuticals Ltd. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Nanocrystalline Megestrol Acetate for Cachectic Stage Locally Advanced Hepatocellular Carcinoma NCT07356037 | Changchun GeneScience Pharmaceutical Co., Ltd. | Phase 3 |
| Recruiting | A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cer NCT07338487 | Second Xiangya Hospital of Central South University | Phase 1 |
| Recruiting | Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine NCT07083557 | Bettina Mittendorfer | — |
| Active Not Recruiting | Therapeutic Efficacy of Nutritional Supplementation in Cachexia Associated With Chronic Pulmonary Disease NCT07288619 | Safeer Khan | N/A |
| Recruiting | A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Cau NCT06989437 | Pfizer | Phase 2 / Phase 3 |
| Recruiting | Body Composition and Psychosocial Factors in ICI-Treated Cancer Patients NCT07130981 | Hacettepe University | — |
| Not Yet Recruiting | A Cluster Randomised Controlled Trial of a Multimodal Integrated Intervention for Kidney Cachexia NCT07107087 | Queen's University, Belfast | N/A |
| Not Yet Recruiting | Enteral Nutrition With L-Carnitine for Cachexia in Non-Small Cell Lung Cancer NCT07035444 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Recruiting | Real-World Study on Nano-Crystalline Megestrol Acetate for Cachexia in TKI-Treated Advanced Digestive Tumors NCT06940102 | Changchun GeneScience Pharmaceutical Co., Ltd. | — |
| Recruiting | CKD Cachexia and Gut Microbiome NCT06986265 | Université Catholique de Louvain | — |
| Recruiting | Influence of Sarcopenia on the Course of the Diseases NCT06829290 | Universitatsmedizin Mainz - 1. Medizinische Klinik | — |
| Completed | A Phase I Study on Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Effica NCT06736275 | Jiangsu Nutai Biologics Co., Ltd | EARLY_Phase 1 |
| Completed | Effect of Dietary Counseling and Nutritional Monitoring in Reducing Cancer-related Cachexia Among Female Oncol NCT07112482 | Pakistan Society of Pediatric Oncology | N/A |
| Recruiting | Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG) NCT06112964 | University of Cambridge | — |
| Recruiting | Olanzapine for Cancer Related Anorexia-cachexia Syndrome NCT06517199 | Mahidol University | Phase 3 |
| Terminated | Muscle Stem Cell Quality in Atrophy NCT06077734 | Maastricht University Medical Center | — |
| Recruiting | REVOLUTION Surgery (REVOLUTION Surgery) NCT05642819 | University of Edinburgh | — |
| Recruiting | Resting Energy Expenditure in Palliative Cancer Patients NCT06206785 | Norwegian University of Science and Technology | — |
| Unknown | Predicting Lung Cancer-Associated Cachexia With PET Imaging NCT05912465 | Medical University of Vienna | N/A |
| Recruiting | A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia NCT05865535 | AVEO Pharmaceuticals, Inc. | Phase 1 |
| Completed | Screening Tool for Malnutrition, Sarcopenia, and Cachexia NCT06516367 | Ain Shams University | — |
| Recruiting | MalnutritiOn Assessment With biOelectrical impedaNce Analysis in gastRic Cancer patIentS Undergoing Multimodal NCT05723718 | Medical University of Lublin | — |
| Completed | Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 NCT05546476 | Pfizer | Phase 2 |
| Terminated | TuLip : Role of the Tumor Environment in Cancer-related Fat Loss NCT05128318 | Université Catholique de Louvain | N/A |
| Unknown | Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated Patients NCT05603585 | National University Hospital, Singapore | N/A |
| Recruiting | Microbiota and Pancreatic Cancer Cachexia NCT05606523 | Genton Graf Laurence | — |
| Completed | A Study to Assess the Safety, Tolerability and Pharmacokinetics of TCMCB07 in Single and Multiple Ascending Do NCT05529849 | Endevica Bio | Phase 1 |
| Recruiting | Assoc. of Genomic Polymorphisms With Cancer Cachexia in Subjects With Panc Adenocarcinoma NCT05376592 | Wake Forest University Health Sciences | — |
| Recruiting | Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms NCT05307367 | University of Copenhagen | N/A |
| Active Not Recruiting | Ruxolitinib for Cancer Cachexia NCT04906746 | Tu Dan | EARLY_Phase 1 |
| Unknown | The Impact of Oligo-Fucoidan in Cancer Cachexia and Sarcopenia NCT05623852 | Taipei Medical University WanFang Hospital | N/A |
| Unknown | Vitamin K2 Supplements for Muscle Recovery NCT05161975 | Lithuanian Sports University | N/A |
| Completed | Study of Comparative Bioavailability and Pharmacokinetics of ACM-001.1) and Pindolol in Healthy Volunteers (HV NCT06028321 | Actimed Therapeutics Ltd | Phase 1 |
| Unknown | Mitochondria Preservation by Exercise Training: a Targeted Therapy for Cancer and Chemotherapy-induced Cachexi NCT05028192 | University of Turin, Italy | — |
| Unknown | MS-20 on Gut Microbiota and Risk/Severity of Cachexia in Pancreatic Cancer Patients NCT04600154 | National Taiwan University Hospital | N/A |
| Unknown | Early Diagnosis of Gastric Cancer Cachexia NCT06277986 | Xijing Hospital | — |
| Recruiting | Patient Recorded Indexing Measurements NCT05899205 | Academisch Ziekenhuis Maastricht | — |
| Completed | Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Adv NCT04803305 | Pfizer | Phase 1 |
| Completed | A Phase 1 Study of AV-380 in Healthy Subjects NCT04815551 | AVEO Pharmaceuticals, Inc. | Phase 1 |
| Completed | Skeletal Muscle Wasting in SARS-CoV-2 NCT04698798 | Hasselt University | N/A |
| Unknown | PeRfusion Emergency VEiNlite Transillumination NCT04628975 | Central Hospital, Nancy, France | N/A |
| Recruiting | Mechanism of Sarcopenia in Heart Failure NCT05063955 | Aarhus University Hospital | — |
| Completed | The Effect of Cannabidiol on Lean Body Mass in Patients Receiving Chemotherapy NCT04585841 | University of Copenhagen | Phase 1 |
| Completed | Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With NCT04299048 | Pfizer | Phase 1 |
| Unknown | The Investigation of the Mechanism of Cachexia Occurrence for Patients With Gastrointestinal Cancer NCT04594863 | Peking Union Medical College Hospital | — |
| Recruiting | Multimodal Program for Cancer Related Cachexia Prevention NCT04627376 | Cyprus University of Technology | N/A |
| Completed | Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography NCT04631978 | Akdeniz University | — |
| Unknown | Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional NCT04907864 | Kil Yeon Lee | Phase 2 |
| Completed | Ultrasound in Evaluating Muscle-Glycogen Content in Cancer Patients NCT03982082 | M.D. Anderson Cancer Center | N/A |
| Unknown | Novel Form of Nutritional Supplementation in Cancer Patients NCT03561610 | University of Erlangen-Nürnberg Medical School | N/A |
| Completed | Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2 NCT03359473 | GlaxoSmithKline | Phase 2 |
| Completed | Single and Multiple Ascending Dose Study of NGM120 in Healthy Adult Subjects NCT03392116 | NGM Biopharmaceuticals, Inc | Phase 1 |
| Completed | Study of Onivyde and 5-FU in Combination With Xilonix for Pancreatic Cancer With Cachexia NCT03207724 | Andrew Hendifar, MD | Phase 1 |
| Unknown | WB-EMS and Individualized Nutritional Support in Gynecological Cancer Patients NCT03570242 | University of Erlangen-Nürnberg Medical School | N/A |
| Terminated | Mitochondrial Respiratory Function in Mammalian Skeletal Muscle NCT02650570 | The University of Texas Medical Branch, Galveston | — |
| Completed | Relation Between Cachexia, Diabetes and periNeural Invasion in PANcreatic Cancer- Biomarkers Substudy NCT03042442 | Iuliu Hatieganu University of Medicine and Pharmacy | — |
| Unknown | Methods for Nutritional Assessment in Cirrhosis NCT02926261 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | — |
| Terminated | Food Reward in Cachexia Induced by Acute or Chronic Disease NCT02798003 | Maastricht University Medical Center | — |
| Unknown | Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract NCT03111771 | University Hospital, Clermont-Ferrand | — |
| Completed | Non-interventional Study to Assess the Frequency of Cachexia in Patients With Non-small Cell Lung Cancer. NCT02968979 | Chugai Pharma France | — |
| Completed | The Effects of a 12 Week Home-based Exercise Intervention on Physical Performance in Patients With Cancers of NCT04802486 | University of Rochester | N/A |
| Unknown | Body Composition Measurements in Chronic Heart Failure NCT02686866 | Hungarian Institute of Cardiology | Phase 4 |
| Completed | Perioperative Glutamine Supplementation and Cachexia NCT05023499 | National Taiwan University Hospital | — |
| Completed | Investigation of the Gut Microbiota in Patients With Acute Myeloid Leukemia NCT03881826 | Université Catholique de Louvain | N/A |
| Completed | Muscle Wasting in Cancer (MWIC) NCT03191955 | University of Edinburgh | — |
| Completed | Role of Myostatin, Activin A and Follistatin Cachexia of ENT Cancers NCT03162042 | University Hospital, Clermont-Ferrand | — |
| Terminated | Pilot Project for Cardiopulmonary and Functional Evaluation in Patients With Pancreatic Cancer Associated Cach NCT02580422 | Indiana University | — |
| Completed | Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the NCT02567773 | GlaxoSmithKline | Phase 1 |
| Completed | Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in NSCLC Cachexia NCT02515032 | Smartfish AS | N/A |
| Completed | Brown Adipose Tissue Activity and Energy Metabolism in Cachexia NCT02500004 | Maastricht University Medical Center | N/A |
| Completed | Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in COPD Cachexia NCT02442908 | Smartfish AS | N/A |
| Completed | Evaluating Weight Stability of Pancreatic Cancer Cachexia Patients NCT02400398 | Andrew Hendifar, MD | — |
| Terminated | Is Clarithromycin a Potential Treatment for Cachexia in People With Lung Cancer? NCT02416570 | University of Nottingham | Phase 2 |
| Completed | Effectiveness of Nutritional Counselling and "Improved Atta" Supplementation in Cachexic Adult Indian Cancer P NCT02561143 | University of Westminster | N/A |
| Completed | Electronic-health Application To Measure Outcomes REmotely Clinical Trial NCT02418546 | Massachusetts General Hospital | N/A |
| Completed | Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy NCT02330926 | Norwegian University of Science and Technology | Phase 3 |
| Unknown | Nabilone Effect on the Attenuation of Anorexia, Nutritional Status and Quality of Life in Lung Cancer Patients NCT02802540 | Instituto Nacional de Cancerologia de Mexico | Phase 2 / Phase 3 |
| Completed | A Study to Evaluate a Skeletal-muscle Microbiopsy Technique With Dynamic Proteomic Measurement in Healthy Male NCT01962454 | GlaxoSmithKline | Phase 1 |
| Completed | Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving Chemotherapy NCT01941810 | Wake Forest University Health Sciences | N/A |
| Completed | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of GSK2881078 in Single and Repeat Doses NCT02045940 | GlaxoSmithKline | Phase 1 |
| Completed | Impact of Nutritional Intervention in Indian Female Cancer Cachexia Patients NCT02350855 | University of Westminster | Phase 2 |
| Active Not Recruiting | Retrospective Review of Cachexia in Lung and Gastrointestinal Cancer Patients NCT03606317 | University of Texas Southwestern Medical Center | — |
| Withdrawn | Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Canc NCT02017925 | Ohio State University Comprehensive Cancer Center | N/A |
| Terminated | Nutritional Problems and Changes in Body Composition in Patients With Non-small Cell Lung Cancer (LEKS) NCT01865903 | Oslo University Hospital | — |
| Completed | Non-Invasive Assessment of Skeletal Muscle Loss in Cancer Patients - Phase II NCT01694602 | The University of Texas Medical Branch, Galveston | — |
| Completed | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2849466 in Healthy NCT01696604 | GlaxoSmithKline | Phase 1 |
| Completed | Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant Growth NCT01647841 | Cornell University | — |
| Completed | Development of a Screening Tool to Detect and Stage Cachectic Cancer Patients NCT01533909 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Study on the Effect of Fish Oil and Appetite NCT01692990 | AAstrup | EARLY_Phase 1 |
| Completed | A Feasibility Study of Multimodal Exercise/Nutrition/Anti-inflammatory Treatment for Cachexia - the Pre-MENAC NCT01419145 | Norwegian University of Science and Technology | N/A |
| Unknown | Impact of Body Composition on Bisoprolol and Ramipril Pharmacokinetics in Patients With Chronic Heart Failure NCT01829880 | The University Clinic of Pulmonary and Allergic Diseases Golnik | — |
| Completed | Clinical Study of BYM338 for the Treatment of Unintentional Weight Loss in Patients With Cancer of the Lung or NCT01433263 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Pharmacokinetics of Megace F and Megace OS Under Fasting and Fed Conditions in Healthy Male Volunteers NCT01397214 | Boryung Pharmaceutical Co., Ltd | Phase 1 |
| Completed | Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 1) NCT01387269 | Helsinn Therapeutics (U.S.), Inc | Phase 3 |
| Completed | Safety and Efficacy of Anamorelin HCl in Patients With Non-Small Cell Lung Cancer-Cachexia (ROMANA 2) NCT01387282 | Helsinn Therapeutics (U.S.), Inc | Phase 3 |
| Completed | Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3 NCT01395914 | Helsinn Therapeutics (U.S.), Inc | Phase 3 |
| Terminated | A Study In Healthy Subjects Of Single Doses of PF-05230901 Injected Under The Skin NCT01262690 | Pfizer | Phase 1 |
| Completed | Prevalence of Cachexia in Patients Undergoing Chemotherapy NCT01939340 | Charite University, Berlin, Germany | — |
| Terminated | Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Lung Cancer Patients NCT00851448 | Fresenius Kabi | N/A |
| Completed | Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients NCT01015274 | The University of Texas Medical Branch, Galveston | — |
| Completed | Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients NCT00994669 | The University of Texas Medical Branch, Galveston | — |
| Terminated | Metabolism of Lipids in Advanced Cancer NCT00962234 | AHS Cancer Control Alberta | — |
| Completed | Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma NCT00878995 | The University of Texas Medical Branch, Galveston | Phase 1 |
| Completed | Individual Dose-escalated Bi-daily Subcutaneously (sc) Ghrelin in Cancer Cachexia: a Phase I/II Study NCT00933361 | Cantonal Hospital of St. Gallen | Phase 1 / Phase 2 |
| Completed | Safety, Tolerance and Efficacy of an Oral Nutritional Supplement in Chronic Heart Failure and Chronic Obstruct NCT00852020 | Fresenius Kabi | N/A |
| Withdrawn | Strength Training on Pancreatic Cancer NCT01395563 | German Cancer Research Center | N/A |
| Completed | Computerized Questionnaires in Assessing Symptoms, Pain, Depression, and Physical Function in Patients With Me NCT00972634 | Norwegian University of Science and Technology | — |
| Completed | Safety, Efficacy and Pharmacokinetics of ALD518 in Patients With Non-Small Cell Lung Cancer-related Fatigue an NCT00866970 | CSL Behring | Phase 2 |
| Completed | SUN11031 in Cachexia Associated With Chronic Obstructive Pulmonary Disease (COPD) NCT00698828 | Daiichi Sankyo | Phase 2 |
| Terminated | Multimodal Treatment Strategy for Cancer Cachexia NCT00625742 | M.D. Anderson Cancer Center | N/A |
| Terminated | Safety and Efficacy Study of Betamarc to Treat Loss of Weight and Appetite in Non-Small Cell Lung Cancer NCT00535015 | Anaborex | Phase 2 |
| Terminated | Haelan and Nutrition in Cancer Patients NCT00558558 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Screening to Predict Weight Loss in Patients With Cancer NCT00710632 | Queen's Medical Center | N/A |
| Completed | Study of GTx-024 on Muscle Wasting (Cachexia) Cancer. NCT00467844 | GTx | Phase 2 |
| Completed | Regimen for the Treatment of Cachexia in Subjects With NSCLC NCT00527319 | Vicus Therapeutics | Phase 2 |
| Terminated | Treatment of Cancer-anorexia Using Megestrol Acetate Concentrated Suspension in Lung or Pancreatic Cancer Pati NCT00637728 | Par Pharmaceutical, Inc. | Phase 3 |
| Terminated | Treatment of Cancer-associated Anorexia Using Megestrol Acetate Concentrated Suspension NCT00637806 | Par Pharmaceutical, Inc. | Phase 3 |
| Completed | Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and NCT00486304 | UNC Lineberger Comprehensive Cancer Center | Phase 1 |
| Withdrawn | Pharmacokinetics and Safety of Transdermal Megestrol Acetate NCT00163072 | Milton S. Hershey Medical Center | Phase 4 |
| Completed | Biological Markers in Patients With Pancreatic Cancer Experiencing Weight Loss NCT00899158 | Case Comprehensive Cancer Center | — |
| Unknown | The Roles of Cytokines in the Mechanism of Insulin Resistance and Energy Balance NCT00172614 | National Taiwan University Hospital | — |
| Completed | Creatine in Treating Patients With Cancer-Associated Weight Loss NCT00081250 | Alliance for Clinical Trials in Oncology | Phase 3 |
| Completed | Evaluate Weight Gain Using 2 Different Formulations of Megestrol Acetate Oral Suspension for AIDS-related Weig NCT00637572 | Endo Pharmaceuticals | Phase 2 |
| Completed | Effects of Infliximab (Remicade) on Fat Free Mass in Patients With Moderate to Severe COPD Suffering From Cach NCT00244192 | Center for Integrated Rehabilitation and Organ Failure Horn | Phase 2 |
| Completed | Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Tr NCT00066248 | University of South Florida | Phase 2 |
| Completed | Etanercept in Treating Cancer-Related Cachexia and Anorexia in Patients With Advanced Cancer NCT00046904 | Mayo Clinic | Phase 3 |
| Completed | A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Pancreatic Cancer Related Ca NCT00060502 | Centocor, Inc. | Phase 2 |
| Completed | Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer NCT00053053 | Radiation Therapy Oncology Group | Phase 3 |
| Completed | Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With U NCT00040885 | Alliance for Clinical Trials in Oncology | Phase 3 |
| Completed | Adenosine Triphosphate in Treating Patients With Advanced Solid Tumors NCT00014248 | Dartmouth-Hitchcock Medical Center | Phase 1 |
| Completed | Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer NCT00006799 | Wake Forest University Health Sciences | Phase 3 |
| Completed | Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer NCT00031785 | Wake Forest University Health Sciences | Phase 3 |
| Completed | Comparison of Megestrol and/or Omega-3 Fatty Acid-Enriched Nutritional Supplement in Treating Patients With Ca NCT00031707 | Alliance for Clinical Trials in Oncology | Phase 3 |
| Completed | Megestrol and Exercise in Treating Patients With Cancer-Related Weight Loss NCT00004912 | Northwestern University | Phase 2 |
| Completed | Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive Women NCT00004400 | Charles Drew University of Medicine and Science | Phase 2 |
| Completed | A Study of Different Doses of Megestrol Acetate in Patients With AIDS Who Have Anorexia and Malnutrition NCT00002300 | Bristol-Myers Squibb | Phase 2 |
| Completed | A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for NCT00000737 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | The Safety and Effectiveness of Megace in HIV-Infected Women NCT00002345 | Bristol-Myers Squibb | Phase 4 |
| Withdrawn | Celecoxib in Managing Pain, Weight Loss, and Weakness in Patients With Advanced Cancer NCT00093678 | Eastern Cooperative Oncology Group | N/A |
| Completed | A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia NCT00002067 | Bristol-Myers Squibb | Phase 3 |