NCT03982082

Ultrasound in Evaluating Muscle-Glycogen Content in Cancer Patients

Feasibility Study of Ultrasound to Evaluate Muscle-Glycogen Content in Patients With Cancer

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial studies how well an ultrasound procedure (non-invasive MuscleSound technology) can be used to learn about levels of glycogen (a type of sugar) in cancer patients during inpatient rehabilitation. The ultrasound information will be processed to represent the energy storage in the muscle. The energy storage in the muscle may help future research to look for dietary plans that can help to increase energy storage, patient exercise tolerance, and functional improvement.

Detailed description

PRIMARY OBJECTIVES: I. Determine feasibility of using non-invasive MuscleSound technology to determine glycogen stores in cancer patients. EXPLORATORY OBJECTIVES: I. Determine the baseline glycogen storage in two different groups of cancer patients, who are undergoing inpatient rehabilitation: (1) those with cachexia; (2) those without cachexia. II. Determine the rate of depletion of muscle-glycogen stores by calculating the "Fuel Rating" score (FRS) at baseline, after 10-min of exercise and then again after 20-min of exercise. III. Determine if there is any correlation between muscle-glycogen (at baseline and its depletion rate over time) and other factors including cancer type, cancer stage, patient age, patient sex, current body mass index (BMI), presence or absence of cachexia, functional measures and patient reported outcomes. OUTLINE: Patients undergo ultrasound via MuscleSound technology over 3 minutes at baseline and immediately after each of 2 physical therapy sessions comprising cycling or walking over 10 minutes.

Conditions

• Cachexia
• Malignant Solid Neoplasm

Interventions

Type	Name	Description
PROCEDURE	Physical Therapy	Undergo physical therapy
OTHER	Questionnaire Administration	Ancillary studies
PROCEDURE	Ultrasound	Undergo ultrasound via MuscleSound technology

Timeline

• Start date: 2019-04-12
• Primary completion: 2024-01-13
• Completion: 2025-01-13
• First posted: 2019-06-11
• Last updated: 2025-01-15

Locations

1 site across 1 country: United States