NCT02500004

Brown Adipose Tissue Activity and Energy Metabolism in Cachexia

Brown Adipose Tissue Activity and Energy Metabolism in Cachexia Induced by Cancer or Chronic Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Accepted

Summary

To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.

Detailed description

This is a prospective, cross-sectional study to determine BAT activity in cachectic patients with pancreatic or non-small cell lung cancer, and in cachectic patients with chronic obstructive pulmonary disease (COPD), and compare results with healthy individuals and non-cachectic COPD patients, matched for age and BMI.

Conditions

• Cachexia
• Neoplasms
• Pulmonary Disease, Chronic Obstructive
• Pancreatic Neoplasms

Interventions

Type	Name	Description
RADIATION	18F-FDG PET-MRI-imaging	BAT activity: 18F-FDG PET-MRI-imaging.
RADIATION	DXA scanning	Body composition: DXA scanning, D2O and MRI.
PROCEDURE	Abdominal subcutaneous adipose tissue biopsy	Inflammatory and metabolic profile of adipose tissue: abdominal subcutaneous adipose tissue biopsy.
PROCEDURE	Blood sampling	Systemic inflammatory profile: blood sampling.
OTHER	Indirect calorimetry	Resting metabolic rate: indirect calorimetry.
DEVICE	Accelerometry	Physical activity level: accelerometry.
OTHER	Double-labeled water	Body composition: DXA scanning, D2O and MRI. Total daily energy expenditure: double-labeled water.

Timeline

• Start date: 2015-06-01
• Primary completion: 2018-07-01
• Completion: 2018-07-01
• First posted: 2015-07-16
• Last updated: 2018-08-03

Locations

1 site across 1 country: Netherlands