NCT02798003

Food Reward in Cachexia Induced by Acute or Chronic Disease

Analysis of Food Reward System in Cachexia Induced by Acute or Chronic Disease

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 44 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer or chronic disease.

Detailed description

The activity in the food reward-circuitry of the brain in patients suffering from cachexia induced by cancer (lung cancer or pancreatic cancer) or chronic disease (chronic obstructive pulmonary disease) will be analysed by using functional magnetic resonance imaging. In addition, the role of the peripheral satiety hormones will be evaluated.

Conditions

• Cachexia
• Chronic Obstructive Pulmonary Disease
• Non-small Cell Lung Cancer
• Pancreatic Cancer

Interventions

Type	Name	Description
OTHER	Functional magnetic resonance imaging (fMRI)	The food-cue elicited response in the reward-circuitry of the brain will be assessed by using fMRI. This technique is based on different magnetic properties of oxygenated and deoxygenated blood. Increased neuronal activity causes an increase in blood flow. Thereby, neuronal activity is indirectly reflected by changes in blood oxygenation level-dependent (BOLD) contrast.

Timeline

• Start date: 2016-12-01
• Primary completion: 2022-02-18
• Completion: 2022-02-18
• First posted: 2016-06-14
• Last updated: 2024-08-06

Locations

1 site across 1 country: Netherlands