| Recruiting | PROgram To Enhance Cardiovascular Risk Trough an Intervention of Nutrition in Bipolar Disorder NCT06488573 | University of Sao Paulo | N/A |
| Not Yet Recruiting | Empagliflozin Adjunctive Therapy in Bipolar Depression NCT07472920 | University of Sao Paulo | N/A |
| Recruiting | RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) NCT07266545 | Mayo Clinic | Phase 4 |
| Withdrawn | Dopamine D3 Receptor Occupancy in Bipolar Depression NCT05060549 | New York State Psychiatric Institute | Phase 4 |
| Enrolling By Invitation | An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE) NCT07217860 | Xenon Pharmaceuticals Inc. | Phase 3 |
| Recruiting | HD-tDCS for Adolescent Bipolar Depression Targeting S1 NCT07246044 | Jiangsu Province Nanjing Brain Hospital | N/A |
| Recruiting | Ketogenic Intervention for Bipolar Depression NCT07121894 | Mayo Clinic | N/A |
| Recruiting | A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disord NCT07172516 | Xenon Pharmaceuticals Inc. | Phase 3 |
| Recruiting | Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Dep NCT07108257 | Sunnybrook Health Sciences Centre | N/A |
| Recruiting | Efficacy and Safety Assessment of Temporal Interference Stimulation to Improve Bipolar Depression NCT07021508 | First Affiliated Hospital of Zhejiang University | N/A |
| Recruiting | Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression Afte NCT05603104 | Dr. Inge Winter | Phase 3 |
| Not Yet Recruiting | SYNCED - SYNChronized Eating in Bipolar Depression Study NCT06560957 | University of Ottawa | N/A |
| Recruiting | The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as NCT05973786 | Dr. Inge Winter | Phase 3 |
| Recruiting | Deep Brain Stimulation of Treatment-Resistant Bipolar Depression NCT06599099 | Wayne Goodman MD | N/A |
| Completed | FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression NCT06620042 | Brian Barnett | Phase 2 |
| Recruiting | Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression NCT06506019 | University Health Network, Toronto | Phase 1 |
| Recruiting | Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression NCT06524505 | Tianjin Anding Hospital | N/A |
| Completed | Task-State-Based Temporal Interference Stimulation (TI) to Improve Depression in Patients With Bipolar Disorde NCT06516991 | First Affiliated Hospital of Zhejiang University | N/A |
| Recruiting | Theta-Burst Stimulation for Bipolar Depression NCT06370988 | Centre for Addiction and Mental Health | N/A |
| Recruiting | Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients NCT06372964 | Intra-Cellular Therapies, Inc. | Phase 3 |
| Recruiting | Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression NCT06088732 | Laureate Institute for Brain Research, Inc. | Phase 1 / Phase 2 |
| Recruiting | Behavioural Activation for Bipolar Depression NCT06022913 | Reykjavik University | N/A |
| Recruiting | Non-invasive BCI and Application Verification for Depressed People NCT06417437 | Shanghai Mental Health Center | Phase 4 |
| Unknown | Intensive Accelerated Theta Burst Stimulation in Treatment of Patients With Bipolar Depression and Suicidality NCT05939115 | Zagazig University | N/A |
| Completed | A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression NCT06229977 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | iTBS in Bipolar I Depression NCT05375214 | Johns Hopkins University | N/A |
| Unknown | Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar Illness NCT05705063 | Stanford University | N/A |
| Unknown | PEA vs. Placebo for Major Depression NCT06063369 | The Israeli Medical Center for Alzheimer's | Phase 2 |
| Suspended | Braining- Aerobic Physical Activity as Add on Treatment in Bipolar Depression NCT05340686 | Region Stockholm | N/A |
| Completed | Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression NCT05339074 | Joshua Rosenblat | Phase 2 |
| Unknown | Bipolar Efficacy Biomarkers for rTMS NCT05393648 | University of California, San Diego | N/A |
| Completed | Ketamine for Treatment-Resistant Bipolar Disorder NCT05004896 | Joshua Rosenblat | Phase 2 |
| Recruiting | aiTBS for Relieving NSSI in Depressive Patients NCT05384405 | Central South University | N/A |
| Active Not Recruiting | Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness NCT05357313 | Chinese University of Hong Kong | N/A |
| Completed | NRX-101 for Bipolar Depression With Subacute Suicidal Ideation NCT03395392 | NeuroRx, Inc. | Phase 2 / Phase 3 |
| Completed | Vortioxetine Adjunctive Treatment in Bipolar Depression NCT05481957 | First Affiliated Hospital of Zhejiang University | Phase 4 |
| Completed | Intensive TMS for Bipolar Depression NCT05228457 | University of Pennsylvania | N/A |
| Unknown | Pulse Width 0.15ms vs 0.30ms in Electroconvulsive Therapy NCT05465915 | Charles University, Czech Republic | EARLY_Phase 1 |
| Active Not Recruiting | Focused Ultrasound Amygdala Neuromodulation NCT05228964 | University of Texas at Austin | N/A |
| Completed | RTMS Feasibility Study on Adolescent Depression Stimulation NCT06126198 | Uppsala University | N/A |
| Recruiting | OSU6162 in Bipolar Depression (OBID) NCT05296356 | Göteborg University | Phase 2 |
| Unknown | Efficacy and Biomarkers of Response of TBS in Treatment Resistant Depression NCT04998773 | Instituto de Investigacion Sanitaria La Fe | N/A |
| Completed | Ketamine As an Adjunctive Therapy for Major Depression (2) NCT04939649 | University of Dublin, Trinity College | Phase 3 |
| Completed | Treatment of Bipolar Depression With Pentoxifylline NCT04417049 | University Health Network, Toronto | EARLY_Phase 1 |
| Completed | EVALUATION OF BLOOD BIOMARKER-BASED DIAGNOSTIC AID IN OUTPATIENTS SUFFERING FROM DEPRESSION NCT06369805 | Les Toises - Psychiatry and Psychotherapy Center | — |
| Unknown | Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study NCT05054699 | University of Sao Paulo | Phase 2 / Phase 3 |
| Recruiting | Brexpiprazole Treatment for Bipolar I Depression NCT04569448 | Douglas Mental Health University Institute | Phase 3 |
| Unknown | Naturalistic Study of Ketamine in the Treatment of Depression NCT05249309 | Hospital de Clinicas de Porto Alegre | — |
| Recruiting | University of Iowa Interventional Psychiatry Service Patient Registry NCT04480918 | Mark Niciu | — |
| Recruiting | PROSPECTIVE EVALUATION OF BLOOD BIOMARKERS AS AN AID TO DIAGNOSTIC AND TREATMENT IN DRUG-NAIVE PATIENTS WITH D NCT06369792 | Les Toises - Psychiatry and Psychotherapy Center | — |
| Completed | 8 Week Multi-site Study of MYDAYIS® for Bipolar Depression NCT04235686 | Mayo Clinic | Phase 2 |
| Completed | Verification of the Reliability and Validity of THINC-it Tool in Bipolar Depression NCT04471454 | Shanghai Mental Health Center | — |
| Completed | Low Dose IL-2 Therapy in Patients With a Depressive Episode in the Course of a Bipolar Disorder NCT04133233 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | Accelerated LFR for Bipolar Patients During the COVID-19 Pandemic NCT04427137 | Centre for Addiction and Mental Health | N/A |
| Recruiting | Delivering Electronic Cognitive Behavioural Therapy to Patients With Bipolar Disorder and Residual Depressive NCT04664257 | Dr. Nazanin Alavi | N/A |
| Completed | Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive NCT04285515 | Intra-Cellular Therapies, Inc. | Phase 3 |
| Completed | 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and NCT07097025 | Dr.Yoav Domany | — |
| Recruiting | Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder NCT03748446 | Massachusetts General Hospital | EARLY_Phase 1 |
| Completed | A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders NCT04226963 | Medical University of Gdansk | — |
| Unknown | NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation NCT03396068 | NeuroRx, Inc. | Phase 3 |
| Completed | Voice Changes During ECT NCT04420793 | Medical University of South Carolina | — |
| Unknown | Bright Light Therapy in the Treatment of Non-seasonal Bipolar Depression NCT03396744 | Assistance Publique - Hôpitaux de Paris | Phase 1 / Phase 2 |
| Completed | Mechanism of Action of Electroconvulsive Therapy NCT04059952 | Massachusetts General Hospital | — |
| Unknown | NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression NCT03396601 | NeuroRx, Inc. | Phase 3 |
| Completed | Comparison of Physical and Virtual Sensory Room in an Inpatient Setting NCT03918954 | Vastra Gotaland Region | N/A |
| Completed | Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression NCT03965871 | Celon Pharma SA | Phase 2 |
| Completed | Using Neuroplasticity-Based Computerized Training to Improve Emotion Regulation in Bipolar Disorder (BRAINS) NCT05683431 | Rush University Medical Center | N/A |
| Completed | 18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder NCT03902613 | New York State Psychiatric Institute | Phase 4 |
| Completed | Triple Chronotherapy in Adolescents NCT03679962 | Billings Clinic | N/A |
| Active Not Recruiting | Ketamine Associated ACC GABA and Glutamate Change and Depression Remission: NCT03573349 | Mayo Clinic | EARLY_Phase 1 |
| Active Not Recruiting | Probiotics to Prevent Relapse After Hospitalization for Bipolar Depression NCT03349528 | Sheppard Pratt Health System | Phase 2 |
| Completed | NRX101 Glx Biomarker Validation Study NCT03402152 | NeuroRx, Inc. | Phase 2 / Phase 3 |
| Suspended | Ketamine Versus Electroconvulsive Therapy in Depression NCT03674671 | University of Ottawa | Phase 3 |
| Completed | Efficacy of Convulsive Therapies During Continuation NCT03711019 | Centre for Addiction and Mental Health | N/A |
| Completed | Efficacy of Convulsive Therapies for Bipolar Depression NCT03641300 | Centre for Addiction and Mental Health | N/A |
| Completed | Behavioural Activation for Bipolar Depression: A Case Series NCT03658824 | University of Exeter | N/A |
| Unknown | Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression NCT03603561 | Universiteit Antwerpen | N/A |
| Unknown | Comparison of Two Forms of Oxcarbazepine for the Treatment of Bipolar Depression NCT03567681 | Collaborative Care Initiative, LLC | Phase 4 |
| Active Not Recruiting | Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression NCT03484494 | Mclean Hospital | N/A |
| Completed | Sequential Therapy for the Treatment of Severe Bipolar Depression. NCT02974010 | NeuroRx, Inc. | Phase 2 |
| Unknown | Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder NCT03279224 | Valerie Taylor | Phase 2 / Phase 3 |
| Active Not Recruiting | Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder NCT03336918 | Brigham and Women's Hospital | — |
| Completed | Lumateperone Monotherapy for the Treatment of Bipolar Depression Conducted Globally NCT03249376 | Intra-Cellular Therapies, Inc. | Phase 3 |
| Terminated | Cannabidiol as an Adjunctive Treatment for Bipolar Depression NCT03310593 | Hospital de Clinicas de Porto Alegre | Phase 2 / Phase 3 |
| Completed | Ketamine as an Adjunctive Therapy for Major Depression NCT03256162 | St Patrick's Hospital, Ireland | Phase 1 |
| Suspended | A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression NCT02719392 | Massachusetts General Hospital | Phase 4 |
| Completed | Effects of Erythropoietin for Cognitive Side-effects of ECT NCT03339596 | Martin Balslev Jørgensen | Phase 2 |
| Completed | Brexpiprazole for Bipolar Depression NCT03427892 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder NCT03468686 | University of Tehran | N/A |
| Terminated | Efficacy of rTMS in Bipolar Depression NCT02749006 | University of British Columbia | N/A |
| Completed | Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression NCT02703363 | Pakistan Institute of Living and Learning | Phase 3 |
| Completed | Trehalose as add-on Therapy in Bipolar Depression NCT02800161 | Consorcio Centro de Investigación Biomédica en Red (CIBER) | Phase 3 |
| Terminated | NeoSync TMS Treatment for Bipolar I Depression NCT02839798 | Butler Hospital | Phase 2 |
| Completed | Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipola NCT02600507 | Intra-Cellular Therapies, Inc. | Phase 3 |
| Completed | Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disor NCT02593643 | Sunnybrook Health Sciences Centre | EARLY_Phase 1 |
| Completed | Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression NCT02600494 | Intra-Cellular Therapies, Inc. | Phase 3 |
| Completed | An Open Label Trial of TMS Therapy for Bipolar Depression NCT02640950 | Sheppard Pratt Health System | N/A |
| Withdrawn | Cytidine- and Creatine-Containing Drug in Treating Bipolar Depression NCT01543139 | Ewha Womans University | Phase 2 |
| Completed | 12-Week Study Evaluating the Efficacy, Safety, and Tolerability of Adjunctive Infliximab for Bipolar I/II Depr NCT02363738 | University Health Network, Toronto | Phase 2 |
| Unknown | Jump Step - A Participatory Approach to Physical Activity & Mental Wellness NCT02549547 | University of British Columbia | N/A |
| Completed | Study to Evaluate the Effects of Switching Different Strength Forms of FK949E in Bipolar Disorder Patients Wit NCT02362412 | Astellas Pharma Inc | Phase 3 |
| Completed | Biosignatures of Latuda for Bipolar Depression NCT02239094 | New York State Psychiatric Institute | N/A |
| Terminated | Chronotherapy Randomized Controlled Trial NCT02176824 | Medical University of South Carolina | N/A |
| Completed | A Prophylactic Trial of Omega-3 Polyunsaturated Fatty Acids in Bipolar Disorder NCT04210804 | National University of Ireland, Galway, Ireland | Phase 2 |
| Completed | A Phase III Study of SM-13496 in Patients With Bipolar I Depression. NCT01986101 | Sumitomo Pharma Co., Ltd. | Phase 3 |
| Completed | Neural and Visual Responses to Light in Bipolar Disorder: A Novel Putative Biomarker NCT02048995 | Northwestern University | — |
| Completed | Treatment of Bipolar Depression With H1-Coil Deep Brain rTMS: Clinical-Cognitive and Safety Evaluation NCT01962350 | University of Sao Paulo | N/A |
| Completed | Feasibility and Tolerability of Adjunct Chronotherapy in Depressed Inpatients NCT02088580 | Medical University of South Carolina | N/A |
| Completed | Pediatric Open-Label Extension Study NCT01914393 | Sumitomo Pharma America, Inc. | Phase 3 |
| Terminated | Asenapine for Bipolar Depression NCT01807741 | University of Cincinnati | Phase 2 |
| Completed | Uridine Adolescent Bipolar Depression Randomized Controlled Trial NCT01805440 | University of Utah | N/A |
| Completed | Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar Depression NCT01929681 | Mclean Hospital | N/A |
| Completed | Vitamin D Supplementation for Bipolar Depression NCT01884844 | University of Massachusetts, Worcester | N/A |
| Terminated | The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression NCT02155972 | Women's College Hospital | Phase 2 |
| Withdrawn | Trial of Ketamine and Lithium Therapy in Bipolar Depression NCT01768767 | Yale University | Phase 2 |
| Completed | Investigating tDCS as a Treatment for Unipolar and Bipolar Depression NCT01562184 | The University of New South Wales | Phase 2 / Phase 3 |
| Unknown | Safety and Efficacy Study of Deep Transcranial Magnetic Stimulation in Bipolar Depression NCT01566591 | Brainsway | N/A |
| Completed | Repetitive Transcranial Magnetic Stimulation for Treating Resistant Bipolar Depression NCT01586793 | Douglas Mental Health University Institute | Phase 2 / Phase 3 |
| Completed | PET and MRI Brain Imaging of Bipolar Disorder NCT01880957 | Stony Brook University | N/A |
| Completed | Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression NCT01390389 | Mclean Hospital | N/A |
| Completed | Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression NCT01403662 | University Health Network, Toronto | Phase 3 |
| Completed | Minocycline for Bipolar Depression NCT01514422 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Completed | Cyclooxygenase-2-Inhibitor Combination Treatment for Bipolar Depression NCT01479829 | Loyola University | Phase 4 |
| Completed | Functional Assessment of Patients With Acute Bipolar Depression After 8 Months of Follow-up NCT01255982 | AstraZeneca | — |
| Terminated | Effect of Intermittent ThetaBurst Stimulation in Treatment-resistant Bipolar Depression NCT02740244 | Hôpital le Vinatier | N/A |
| Completed | Evaluate the Efficacy and Safety of Quetiapine Fumarate (SEROQUEL) Extended Release as Monotherapy in the Trea NCT01256177 | AstraZeneca | Phase 3 |
| Completed | Lurasidone HCI - A 6-week Phase 3 Study of Patients With Bipolar I Depression NCT01284517 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Longitudinal Study on the Neuroprotective and Neurotrophic Effects of Lithium NCT01919892 | University of Sao Paulo | Phase 4 |
| Unknown | Neurophysiologic Changes in Patients With Bipolar Depression NCT01213121 | Seoul National University Bundang Hospital | Phase 4 |
| Withdrawn | Efficacy of Quetiapine XR Versus Divalproex on Clinical Outcome Quality of Sleep and Quality of Life in Bipola NCT01587066 | Bo-Hyun Yoon | Phase 4 |
| Completed | Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression NCT01881763 | Northwell Health | Phase 4 |
| Suspended | Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 Treatments NCT01557192 | Mclean Hospital | Phase 1 |
| Completed | Neuroimaging Studies of the Treatment of Bipolar Depression With Citalopram NCT01639482 | Massachusetts General Hospital | — |
| Terminated | Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression NCT01309581 | James Murrough | N/A |
| Terminated | Magnetic Resonance Imaging Study of Lisdexamfetamine for Bipolar Depression NCT01051440 | Steward St. Elizabeth's Medical Center of Boston, Inc. | Phase 4 |
| Terminated | Efficacy Study of Lisdexamfetamine to Treat Bipolar Depression NCT01093963 | Lindner Center of HOPE | Phase 3 |
| Completed | Bipolar Depression Before and After Lamotrigine Treatment NCT01042496 | Mayo Clinic | Phase 3 |
| Completed | Proof Of Mechanism Study To Determine Efficacy Of PF-04455242 In Blocking Spiradoline (PF-00345768) Stimulated NCT00988949 | Pfizer | Phase 1 |
| Completed | Safety and Efficacy of RGH-188 (Cariprazine) in Bipolar Depression NCT00852202 | Forest Laboratories | Phase 2 |
| Completed | Study Comparing the Tolerability of Seroquel IR With Seroquel XR in Patients With Bipolar Depression NCT00926393 | AstraZeneca | Phase 4 |
| Completed | Berlin Magnetic Seizure Therapy Depression Trial 01 NCT00914680 | Charite University, Berlin, Germany | Phase 3 |
| Completed | Quetiapine XR Versus Sertraline in Acute Bipolar Depression as add-on Therapy NCT00857584 | AstraZeneca | Phase 3 |
| Completed | A Study for Assessing Treatment of Patients Ages 10-17 With Bipolar Depression NCT00844857 | Eli Lilly and Company | Phase 4 |
| Completed | Lurasidone - A 24-week Extension Study of Patients With Bipolar I Depression NCT00868959 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on) NCT00868452 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Monotherapy) NCT00868699 | Sumitomo Pharma America, Inc. | Phase 3 |
| Completed | A First In Human Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of PF-04455242 In Single Risi NCT00938301 | Pfizer | Phase 1 |
| Completed | Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance NCT00835120 | University Hospitals Cleveland Medical Center | Phase 4 |
| Completed | Bipolar Study of Seroquel XR With Pramipexole Dihydrochloride NCT00893841 | Dr. D McIntosh & Dr. K Kjernisted Clinical Research Inc. | Phase 2 |
| Withdrawn | What is the Antidepressant Mechanism of Action of Quetiapine in Bipolar Depression? NCT00817323 | University of British Columbia | Phase 3 |
| Unknown | Double Blind Randomized Controlled, H1 Coil In Subjects With Bipolar Depression NCT00657735 | Shalvata Mental Health Center | N/A |
| Completed | Pediatric Bipolar Depression NCT00811473 | AstraZeneca | Phase 3 |
| Terminated | Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder NCT00805493 | National Institute of Mental Health (NIMH) | Phase 2 |
| Completed | Determination of Absorption and Elimination of Lamotrigine-XR NCT00789113 | University of Minnesota | Phase 1 / Phase 2 |
| Completed | A Trial of SAMe for Treatment-Resistant Bipolar Depression NCT00762268 | Mclean Hospital | N/A |
| Completed | The Use of a Mitochondrial Enhancement Treatment in Bipolar Disorder NCT00719706 | Mclean Hospital | Phase 2 |
| Completed | CoQ10 in Geriatric Bipolar Depression NCT00720369 | Mclean Hospital | N/A |
| Completed | Treatment Clinical Practice in Bipolar Depression in Spain NCT00757328 | AstraZeneca | — |
| Completed | Safety, Tolerability and Pharmacokinetics of Repeat Doses of GSK1014802. NCT00908154 | Biogen | Phase 1 |
| Completed | Low Field Magnetic Stimulation in Mood Disorders Using the LFMS Device NCT00578383 | Mclean Hospital | N/A |
| Completed | Treatment for Bipolar Depression: Acute & Prophylactic Efficacy With Citalopram NCT00562861 | Tufts Medical Center | Phase 2 / Phase 3 |
| Terminated | Ceftriaxone in the Management of Bipolar Depression NCT00566111 | Yale University | N/A |
| Completed | Quetiapine Efficacy in Bipolar Depression Study NCT00523601 | AstraZeneca | — |
| Completed | Riluzole in the Treatment of Bipolar Depression NCT00544544 | Mclean Hospital | N/A |
| Withdrawn | Transcranial Magnetic Stimulation for Bipolar Depression NCT00470639 | The University of New South Wales | Phase 1 / Phase 2 |
| Terminated | A Pilot Study Assessing EmSam in Bipolar Depression NCT00535262 | New York State Psychiatric Institute | Phase 4 |
| Completed | Medication, Weight Gain and GI Hormones NCT00384332 | Vanderbilt University | Phase 4 |
| Completed | Safety Study of Ziprasidone (Geodon) for the Depressive Mixed State NCT00490542 | Tufts Medical Center | Phase 2 |
| Terminated | Treatment Resistant Bipolar Depression NCT00272025 | Queen's University | Phase 1 |
| Terminated | The Antidepressant Efficacy of the Anticholinergic Scopolamine NCT00369915 | National Institute of Mental Health (NIMH) | Phase 2 |
| Completed | A Preliminary Study of the Effectiveness and Tolerability of Aripiprazole in Bipolar Depression NCT00363337 | Lindner Center of HOPE | Phase 4 |
| Withdrawn | RU-486 in the Treatment of Bipolar Depression NCT00359125 | University of British Columbia | Phase 2 |
| Completed | Evaluation of the H-Coil Transcranial Magnetic Stimulation (TMS) Device in the Treatment of Bipolar Depression NCT00444938 | Shalvata Mental Health Center | Phase 1 |
| Completed | Lamotrigine Therapy in Geriatric Bipolar Depression NCT00720473 | Mclean Hospital | N/A |
| Completed | Phase II Study to Assess RG2417 in the Treatment of Bipolar I Depression NCT00322764 | Repligen Corporation | Phase 2 |
| Completed | Levetiracetam in the Management of Bipolar Depression NCT00566150 | Yale University | N/A |
| Completed | Aripiprazole Treatment of Bipolar Depression NCT00198198 | Indiana University School of Medicine | Phase 4 |
| Completed | Carbamazepine Extended-Release for the Treatment of Bipolar Depression NCT00203567 | Tuscaloosa Research & Education Advancement Corporation | Phase 4 |
| Completed | Seroquel in Bipolar Depression Versus Lithium NCT00206141 | AstraZeneca | Phase 3 |
| Completed | Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression NCT00305578 | Indiana University School of Medicine | Phase 4 |
| Completed | Seroquel in Bipolar Depression Versus SSRI NCT00119652 | AstraZeneca | Phase 3 |
| Completed | Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study NCT00217165 | Mclean Hospital | Phase 2 |
| Terminated | Low Field Magnetic Stimulation Treatment for Bipolar Depression NCT00217217 | Mclean Hospital | Phase 3 |
| Completed | The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive Functioning NCT00566735 | Massachusetts General Hospital | Phase 3 |
| Completed | Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder NCT00203528 | Tuscaloosa Research & Education Advancement Corporation | Phase 4 |
| Completed | Melancholic Symptoms in Bipolar Depression and Responsiveness to Lamotrigine NCT02989727 | University of Saskatchewan | Phase 4 |
| Completed | Functional Connectivity in Mood Regulating Circuit In Bipolar Depression and Mania NCT00457054 | Indiana University School of Medicine | Phase 4 |
| Terminated | Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies NCT00055575 | National Institute of Mental Health (NIMH) | Phase 2 |
| Completed | A Study To Investigate The Antidepressant Effect Of Lamotrigine In Patients With Bipolar Disorder Using Lithiu NCT00224510 | GlaxoSmithKline | Phase 3 |
| Available | NRX-101 Expanded Access NCT05779267 | NeuroRx, Inc. | — |