NCT05357313

Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness

A Randomized Placebo-controlled Trial for Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized placebo-controlled trial to examine the efficacy of six-week bright light therapy as adjunctive treatment for patient with bipolar depression and eveningness.

Detailed description

This randomized placebo-controlled trial aims to evaluate the efficacy of adjunctive BLT in addition to their maintenance treatment in reducing depressive symptoms. The second aim of the study is to explore the effects of BLT on sleep-wake changes and the sleep disturbances. Method: Each eligible participant will be randomized to either i) bright light therapy (BLT) or ii) inactive negative ion generator (placebo) treatment for 30-minutes daily at the midday for a total of six weeks. Participants will be evaluated at baseline, 2nd, 4th and 6th week for depression and insomnia symptoms. Actigraphy will be done at baseline and in the last week of treatment.

Conditions

• Bipolar Depression

Interventions

Type	Name	Description
DEVICE	Bright light therapy	Exposure to 10,000lux bright light for 30minutes a day for six weeks
DEVICE	Inactive negative ion generator	Exposure to an inactive negative ion generator for 30 minutes a day for six weeks

Timeline

• Start date: 2022-06-02
• Primary completion: 2025-11-28
• Completion: 2026-06-01
• First posted: 2022-05-02
• Last updated: 2026-03-05

Locations

1 site across 1 country: Hong Kong