NCT01213121

Neurophysiologic Changes in Patients With Bipolar Depression

Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

* To examine differences in neurophysiologic parameters between unmedicated patients with bipolar depression and healthy controls * To examine within-subject changes in neurophysiologic parameters in patients with bipolar depression treated with quetiapine

Detailed description

* Alterations of neurophysiologic regulation has been suggested in patients with major depressive disorder or bipolar disorders * Depressive phase of bipolar disorder shows multi-faceted characteristics different from unipolar depression * Quetiapine is an atypical antipsychotic licensed for treatment of bipolar depression * The aim of this study is to investigate the pattern of neurophysiologic dysregulation in bipolar depression and its changes induced by quetiapine treatment

Conditions

• Bipolar Depression

Interventions

Type	Name	Description
DRUG	Quetiapine	oral tablet/25-600mg per day/once a day/six weeks

Timeline

• Start date: 2010-09-01
• Primary completion: 2014-10-01
• Completion: 2015-10-01
• First posted: 2010-10-01
• Last updated: 2013-11-21

Locations

1 site across 1 country: South Korea