| Not Yet Recruiting | Resting-State fMRI Study of Functional Connectivity After Gamma Knife Radiosurgery in Trigeminal Neuralgia NCT07357025 | Assistance Publique Hopitaux De Marseille | N/A |
| Not Yet Recruiting | The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia NCT06977932 | Yuanyuan Wu | N/A |
| Not Yet Recruiting | Risk Factors for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon Compression NCT07238244 | Second Xiangya Hospital of Central South University | — |
| Not Yet Recruiting | Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia NCT07216547 | Rutgers, The State University of New Jersey | — |
| Not Yet Recruiting | Efficacy and Safety of Irregular Pulsed Radiofrequency (Sluijter-Teixera Poisson) Versus Regular Pulsed Radiof NCT07275229 | Sohag University | N/A |
| Not Yet Recruiting | Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRo NCT07135024 | Gerrit A Schubert | — |
| Not Yet Recruiting | The Synergism and Attenuation Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia NCT07074561 | Yuanyuan Wu | N/A |
| Not Yet Recruiting | Comparison of Two Types of Radiofrequency Treatment for Trigeminal Neuralgia NCT07013500 | Mesut Bakır | N/A |
| Active Not Recruiting | Comparison b/w Carbamazepine vs Oxcarbazepine in Treatment of Trigeminal Neuralgia NCT07252453 | Abbasi Shaheed Hospital | N/A |
| Recruiting | Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia NCT06851910 | Hospital Universitari de Bellvitge | — |
| Completed | Impact of Teflon Technique on Recurrence After Microvascular Decompression for Trigeminal Neuralgia NCT07046247 | University of Valencia | — |
| Recruiting | Comparison of Pulsed and Thermal Radiofrequency for Trigeminal Neuralgia NCT06684275 | Zagazig University | N/A |
| Recruiting | CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal NCT06620172 | Zagazig University | N/A |
| Recruiting | Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion NCT05451251 | Université de Sherbrooke | Phase 1 |
| Active Not Recruiting | Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia NCT06849219 | Jinnah Postgraduate Medical Centre | Phase 4 |
| Active Not Recruiting | Efficacy, Safety, and Tolerability of SR750 in Patients With Trigeminal Neuralgia NCT06571448 | Shanghai SIMR Biotechnology Co., Ltd. | Phase 2 |
| Recruiting | OnabotulinumtoxinA for Trigeminal Neuralgia NCT06216886 | Stanford University | Phase 4 |
| Enrolling By Invitation | Botulinum Toxin Type A for Injection (HengLi®) in the Treatment of Trigeminal Neuralgia NCT06410859 | LKGS_277 | Phase 2 |
| Recruiting | Pregabalin as an add-on Therapy to Carbamazepine in Trigeminal Neuralgia Patients NCT06357260 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Recruiting | Masseter Muscle Thickness in Gasser Ganglion Radiofrequency Treatment NCT06278194 | Başakşehir Çam & Sakura City Hospital | N/A |
| Recruiting | A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adul NCT06213155 | St. Olavs Hospital | N/A |
| Recruiting | Emotion and Memory in Chronic Neuropathic Pain NCT06518421 | University Health Network, Toronto | — |
| Completed | Effect of Non-invasive Photobiomodulation Therapies in Patients With Trigeminal Neuralgia NCT06440356 | University of Gaziantep | N/A |
| Completed | Nucleo CMP and Neurorubine Versus Carbamazepine for Classical Trigeminal Neuralgia NCT07304453 | Karbala University | Phase 2 |
| Recruiting | Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal Neuralgia NCT06779578 | Alexandria University | N/A |
| Withdrawn | Analgesic Effect of Ultrasound Guided Maxillary Nerve Block in Trigeminal Neuralgia NCT06129071 | Varazdin General Hospital | N/A |
| Unknown | Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia NCT06315790 | Henrik Schytz | Phase 3 |
| Recruiting | Trigeminal Evoked Responses to Improve Rhizotomy NCT05738096 | University of Minnesota | EARLY_Phase 1 |
| Completed | Artificial Intelligence-powered Virtual Assistant for Emergency Triage in Neurology NCT06334796 | Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia | EARLY_Phase 1 |
| Withdrawn | 802NP301 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia NCT03070132 | Biogen | Phase 3 |
| Enrolling By Invitation | Artificial Intelligence to Predict Surgical Outcomes and Assess Pain Neuromodulation in Trigeminal Neuralgia S NCT05810428 | IRCCS San Raffaele | N/A |
| Withdrawn | 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia NCT03637387 | Biogen | Phase 3 |
| Recruiting | Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Peripheral Neuro NCT06290661 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | N/A |
| Completed | Trigeminal Ganglion RFT vs Maxillary/Mandibular PRF in the Treatment of Trigeminal Neuralgia NCT06366139 | Diskapi Teaching and Research Hospital | N/A |
| Recruiting | Neurosurgical Outcome Network NCT06724029 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Unknown | Paresthesia-free Peripheral Nerve Field Stimulation for Trigeminal Neuralgia (FreeST Trial) NCT05615714 | University Health Network, Toronto | Phase 1 / Phase 2 |
| Recruiting | Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cells Exosomes for Trigeminal Neuralgia NCT05152368 | The Foundation for Orthopaedics and Regenerative Medicine | Phase 1 |
| Completed | Predictive Factors in Maxillary and Mandibular Nerve Radiofrequency Treatment for Trigeminal Neuralgia NCT06240494 | Diskapi Teaching and Research Hospital | — |
| Completed | Comparison of the Radiofrequency Treatments for the Treatment of Trigeminal Neuralgia. NCT05516888 | Diskapi Teaching and Research Hospital | N/A |
| Withdrawn | Comorbid Painful TMD Among Trigeminal Neuralgia NCT05914558 | University of Minnesota | — |
| Recruiting | Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional C NCT05051072 | Fondation Ophtalmologique Adolphe de Rothschild | N/A |
| Active Not Recruiting | Transcranial Magnetic Stimulation for Chronic Neuropathic Pain NCT05593237 | University of California, San Francisco | N/A |
| Recruiting | Trigeminal Neuralgia Electrophysiology NCT05269472 | University of Minnesota | — |
| Active Not Recruiting | An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia. NCT05217628 | Noema Pharma AG | Phase 2 / Phase 3 |
| Recruiting | Observational Study on the Treatment of Trigeminal Neuralgia by Radiosurgery NCT05677243 | Centre Hospitalier Princesse Grace | — |
| Completed | A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia NCT06019338 | Noema Pharma AG | — |
| Completed | Comparison Between Magnetic Field and Laser Therapy in Management of Trigeminal Neuralgia NCT05075707 | Delta University for Science and Technology | N/A |
| Completed | Feasibility of Olive Oil for Reducing Facial Pain of Trigeminal Neuralgia NCT05032573 | University of Florida | N/A |
| Unknown | Comparision Efficacy of Carbamazepine & Oxcarbazepine in the Treatment of Trigeminal Neuralgia- a Randomised C NCT04996199 | Postgraduate Institute of Dental Sciences Rohtak | Phase 4 |
| Completed | Comparative Study Between Transcoronoid and Infrazygomatic Anterior Maneuvers NCT05712993 | Iraqi Board of medical specialties | N/A |
| Active Not Recruiting | MR Guided Focused Ultrasound (FUS) for the Treatment of Trigeminal Neuralgia NCT04579692 | University of Maryland, Baltimore | N/A |
| Unknown | Transcriptome Sequencing Analysis of Whole Blood From Patients With Trigeminal Neuralgia NCT04923399 | Peking University People's Hospital | — |
| Completed | 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia NCT04570293 | Beijing Tiantan Hospital | Phase 4 |
| Completed | Pathophysiological Mechanisms of Trigeminal Neuralgia - Neurophysiological Assessment of the Blink-reflex NCT05328661 | Danish Headache Center | — |
| Unknown | Comparative Study inTreatment of Trigeminal Neuralgia NCT04801407 | Sohag University | N/A |
| Completed | Sphenopalatine Ganglion Block with Tx360 for Trigeminal Neuralgia NCT06663410 | Aretaieio Hospital | — |
| Completed | The Efficacy and Safety of Pulsed Radiofrequency Combined With Continuous Radiofrequency for the Trigeminal Ne NCT04174443 | Beijing Tiantan Hospital | N/A |
| Unknown | FMRI Assessment After Radiofrequency in Trigeminal Neuralgia NCT03305289 | Assiut University | N/A |
| Withdrawn | Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache NCT04353505 | Weill Medical College of Cornell University | Phase 1 |
| Completed | Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia NCT04158752 | Duke University | Phase 4 |
| Unknown | Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks NCT04467398 | Seoul National University | — |
| Unknown | The Clinical Benefits of the Combination Use of Acupuncture and Antihistamine on Trigeminal Neuralgia NCT04384224 | China Medical University Hospital | N/A |
| Completed | Greater Occipital Nerve and Cervical Region Injection in Patients With Trigeminal Neuralgia NCT04505280 | Dr. Lutfi Kirdar Kartal Training and Research Hospital | N/A |
| Unknown | Defining Core Outcome Sets in Trigeminal Neuralgia NCT04272385 | University College, London | — |
| Completed | Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal N NCT03865940 | Vanderbilt University Medical Center | Phase 2 |
| Unknown | A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain, Quality of Life an NCT04117035 | University of Leeds | N/A |
| Unknown | Efficacy and Tolerability of Erenumab in Patients With Trigeminal Neuralgia NCT04054024 | Danish Headache Center | Phase 2 |
| Terminated | Trial for Treatment Refractory Trigeminal Neuralgia NCT03941834 | Pfizer | Phase 2 |
| Terminated | Neurosurgical Transitional Care Programme NCT03593330 | Barts & The London NHS Trust | N/A |
| Withdrawn | Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia NCT03374709 | University of Colorado, Denver | Phase 4 |
| Completed | Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 20 NCT03712254 | Danish Headache Center | — |
| Completed | Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital NCT03669744 | University Hospital, Limoges | — |
| Completed | Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia NCT03580317 | Zhejiang Chinese Medical University | N/A |
| Unknown | Botulinum Toxin for Trigeminal Neuralgia NCT03331913 | The First Affiliated Hospital of Zhengzhou University | Phase 3 |
| Unknown | Postoperative Analgesia in Patients With Microvascular Decompression NCT03152955 | Xiangya Hospital of Central South University | Phase 4 |
| Completed | Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia NCT02713646 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Unknown | An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia NCT02801630 | Rosenblum, Jonathan I., DPM | N/A |
| Unknown | An Follow-up Study of Occlusal Adjustment for Orofacial Pain NCT02856906 | Meiqing Wang | N/A |
| Completed | PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants NCT02831517 | Biogen | Phase 1 |
| Recruiting | The Will Erwin Headache Research Center - Cluster Headache Study NCT02910323 | The University of Texas Health Science Center, Houston | — |
| Completed | Pulsed Radiofrequency in Trigeminal Neuralgia NCT04355221 | Mansoura University | N/A |
| Completed | Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. NCT02662972 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Terminated | Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical T NCT02624661 | Norwegian University of Science and Technology | Phase 1 / Phase 2 |
| Completed | Comparing Clinical Benefits of Gamma Knife and Microvascular Decompression for Trigeminal Neuralgia NCT03991039 | University of Baghdad | N/A |
| Completed | Classical Trigeminal Neuralgia and Sodium Channel Mutations NCT03656497 | Danish Headache Center | — |
| Active Not Recruiting | RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery NCT02708810 | University of Alabama at Birmingham | N/A |
| Completed | Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia NCT02473016 | Capnia, Inc. | Phase 2 |
| Completed | PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers NCT02359344 | Biogen | Phase 1 |
| Terminated | Incobotulinum Toxin for the Treatment of Trigeminal Neuralgia NCT02088632 | Thomas Jefferson University | Phase 2 |
| Terminated | Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia NCT02427074 | University of Sao Paulo | N/A |
| Withdrawn | CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap NCT01932255 | St. Olavs Hospital | — |
| Completed | Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - a Prospective Study in 60 Patients NCT04371575 | Stine Maarbjerg, MD PhD | — |
| Completed | Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency NCT03396406 | Assiut University | N/A |
| Completed | Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program NCT03838393 | Danish Headache Center | — |
| Completed | Efficacy and Complications of Microvascular Decompression NCT04445766 | Danish Headache Center | — |
| Completed | A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia NCT01540630 | Biogen | Phase 2 |
| Recruiting | RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT NCT01885299 | The Radiosurgery Society | — |
| Completed | A Nasal Applicator for the Treatment of Trigeminal Neuralgia NCT01761604 | Chicago Anesthesia Pain Specialists | N/A |
| Completed | Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain NCT01447108 | Sheba Medical Center | Phase 4 |
| Completed | A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia NCT01364285 | Stanford University | — |
| Completed | Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study NCT03066037 | Charite University, Berlin, Germany | — |
| Completed | Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbnes NCT01364272 | Stanford University | — |
| Terminated | A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia NCT01364259 | Stanford University | Phase 3 |
| Unknown | Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients NCT00866424 | Xijing Hospital | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia NCT00913107 | University of Malaya | Phase 2 / Phase 3 |
| Completed | Hippocampal Radiation Exposure and Memory NCT00603694 | University Health Network, Toronto | — |
| Completed | EEG Monitoring to Assess Emergence From Neuroanesthesia NCT00443807 | University of Manitoba | N/A |
| Withdrawn | Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception NCT00349050 | Medical University of South Carolina | Phase 2 / Phase 3 |
| Completed | The Effect of Intravenous Lidocaine on Trigeminal Neuralgia NCT01955967 | Pain Relief & Palliative Care Center, Athens, Greece | N/A |
| Completed | Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia NCT00203229 | Thomas Jefferson University | N/A |
| Completed | Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia NCT00004431 | University of Pittsburgh | N/A |
| Completed | Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain NCT00001725 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |