NCT03152955

Postoperative Analgesia in Patients With Microvascular Decompression

Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Xiangya Hospital of Central South University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Perioperative pain is caused by a variety of harmful factors through multiple mechanisms, therefore, reasonable postoperative analgesia should be combined with drugs or measures of different mechanism , which is called multimodal analgesia. Multimodal analgesia could minimize side effects and achieve a better analgesic effect. Commonly used strategies of multimodal analgesia are oral analgesic drug, nerve block, patient controlled analgesia and so on. This study will observe the effect of multimodal analgesia on postoperative pain in patients with microvascular decompression and record side effects. Finally, it will provide technical support for the guidance of postoperative analgesia in patients of trigeminal neuralgia.

Detailed description

The investigators will collect 90 cases which will be divided into 3 groups. Patients in Group A will receive scalp nerve block and patient-controlled analgesia which contains sufentanil and ondansetron. In Group B, patient-controlled analgesia which contains sufentanil, ondansetron and ketamine will be applied. In Group C, patient-controlled analgesia which contains sufentanil and ondansetron will be applied.

Conditions

• Trigeminal Neuralgia

Interventions

Type	Name	Description
DRUG	Ketamine	Ketamine will be applied in patient-controlled analgesia.
OTHER	scalp nerve block	Scalp nerve block is performed for the blockade of the greater occipital, superficial cervical and lesser occipital nerves with 0.5% ropivacaine.
DRUG	ondansetron	Ondansetron(13ug/kg/h) is applied in patient-controlled analgesia.
DRUG	Sufentanil	Sufentanil(0.02ug/kg/h) is applied in patient-controlled analgesia.

Timeline

• Start date: 2017-05-15
• Primary completion: 2018-05-15
• Completion: 2018-05-15
• First posted: 2017-05-15
• Last updated: 2018-05-15

Locations

1 site across 1 country: China