NCT07252453

Comparison b/w Carbamazepine vs Oxcarbazepine in Treatment of Trigeminal Neuralgia

Comparison of Carbamazepine and Oxcarbazepine In the Treatment of Trigeminal Neuralgia

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 122 (actual)
• Sponsor: Abbasi Shaheed Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

In this Study investigator is comparing the effectiveness and outcomes of two drugs used un the treatment of trigeminal neuralgia , Carbamazepine vs Oxcarbazepine

Detailed description

In this open pilot open label randomized controlled trial, Investigator is comparing the effectiveness and outcomes of two drugs used un the treatment of trigeminal neuralgia, Carbamazepine vs Oxcarbazepine , hypothesis would be that oxcarbazepine has equal or better outcomes comparatively with less side effects

Conditions

• Trigeminal Neuralgia

Interventions

Type	Name	Description
DRUG	Carbamazepine	Carbamazepine is a conventional drug used to treat trigeminal neuralgia. It primarily works by blocking voltage-gated sodium channels in nerve cells, which prevents rapid and repetitive firing of action potentials and reduces abnormal electrical activity in the brain.
DRUG	oxcarbazepine	Oxcarbazepine is comparatively new approved drug in the treatment of TGN. Oxcarbazepine is a prodrug that is rapidly converted to its active metabolite, (monohydroxy metabolite or MHD). This active form works by blocking voltage-sensitive sodium channels in the brain, which stabilizes over-excited nerve membranes and prevents the rapid spread of abnormal electrical activity

Timeline

• Start date: 2025-05-20
• Primary completion: 2025-11-20
• Completion: 2025-12-01
• First posted: 2025-11-26
• Last updated: 2025-11-26

Locations

1 site across 1 country: Pakistan