| Recruiting | IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study NCT07217873 | Columbia University | Phase 2 / Phase 3 |
| Recruiting | Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery NCT07218133 | Alexander T. Yahanda | N/A |
| Recruiting | Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine NCT06471348 | Boston Children's Hospital | N/A |
| Completed | Reassessing the Role of Routine Radiographs After Spinal Fusion Surgery NCT07200557 | Universitaire Ziekenhuizen KU Leuven | — |
| Recruiting | Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal NCT06368245 | AO Foundation, AO Spine | — |
| Recruiting | Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery NCT06357234 | IWK Health Centre | Phase 2 |
| Enrolling By Invitation | Perioperative Sleep Quality and Postoperative Pain Outcomes NCT06054802 | Grant Heydinger | — |
| Recruiting | Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion NCT06744907 | Akron Children's Hospital | Phase 4 |
| Recruiting | Clinical Evaluation and Cost-effectiveness Analysis of 3D Digital Surgery in Traumatology NCT06603831 | Corporacion Parc Tauli | N/A |
| Not Yet Recruiting | Perioperative Smoking Cessation in Elderly Chinese Undergoing Spinal Fusion NCT06578611 | The Second Hospital of Shandong University | — |
| Recruiting | Pedicle Screw Malposition in Spine Arthrodesis Surgeries With O-ARM-guided Navigation NCT06020417 | Federal University of Piaui | N/A |
| Enrolling By Invitation | Low Dose Dexmedetomidine as a Postoperative Pain Adjunct NCT06067893 | Nichole Doyle | Phase 4 |
| Enrolling By Invitation | Active Video Game-Based Exercise Training and Stability Training After AIS Surgery NCT06498232 | Istanbul University - Cerrahpasa | N/A |
| Recruiting | Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine Surgery NCT06233617 | Poznan University of Medical Sciences | Phase 4 |
| Recruiting | Kids With Iron Deficiency and Scoliosis NCT06042699 | Columbia University | N/A |
| Recruiting | Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion NCT05461092 | University of Iowa | EARLY_Phase 1 |
| Recruiting | Pulse-Width Modulation NCT06120231 | Dartmouth-Hitchcock Medical Center | N/A |
| Unknown | Yoga for Adolescent Idiopathic Scoliosis (AIS) Patients NCT06003010 | University of Texas at Austin | N/A |
| Completed | Enhanced Recovery After Surgery in Oblique Lumbar Interbody Fusion NCT05959343 | Seoul National University Hospital | N/A |
| Recruiting | Photobiomodulation for Lower Back Pain Post Spinal Fusion and Decompression Surgery NCT06282770 | University of California, Los Angeles | N/A |
| Unknown | Spinal Fusions Steroid Study NCT05287035 | University of Texas at Austin | EARLY_Phase 1 |
| Unknown | Recombinant Human Bone Morphogenetic Protein-2(rhBMP-2) in Patients With Osteoporosis After Lumbar Fusion NCT05911477 | Xijing Hospital | N/A |
| Active Not Recruiting | Pelvic Fixation and Fusion During Multilevel Spinal Surgery NCT05640908 | SI-BONE, Inc. | — |
| Unknown | Ropivacaine Pharmacokinetics After Erector Spinae Block NCT05755334 | McGill University Health Centre/Research Institute of the McGill University Health Centre | Phase 4 |
| Unknown | Spinal Cord Stimulation Versus Instrumentation for FBSS NCT05466110 | University Hospital Augsburg | N/A |
| Active Not Recruiting | Intercorporal Bone Graft Measurement Study NCT05565456 | Rijnstate Hospital | — |
| Active Not Recruiting | Lumbar Fusion With Porous Versus Non-Porous Cages NCT05583864 | Francis Farhadi | N/A |
| Completed | Efficacy of ARISTA-AH for Restoring Hemostasis Following Posterior Long-segment Spinal Fusion. NCT05323448 | Polyclinique Bordeaux Nord Aquitaine | N/A |
| Recruiting | A Post Market Surveillance on INFUSE Bone Graft NCT05299762 | Medtronic Spinal and Biologics | — |
| Completed | Diaphragmatic Breathing Exercise for Patients Undergoing Arthrodesis Surgery for Adolescent Idiopathic Scolios NCT05311826 | Istituto Ortopedico Rizzoli | N/A |
| Unknown | Postoperative Pain Control Using Local Wound Infiltration in Adolescent Idiopathic Surgery NCT04730531 | Boston Children's Hospital | N/A |
| Completed | Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery NCT05345249 | Ilse van de Wijgert | Phase 4 |
| Completed | The Effect of Foot Massage on Pain, Sleep Quality and Early Discharge in Patients Undergoing Spinal Surgery NCT05354830 | Istanbul Medeniyet University | N/A |
| Recruiting | Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis NCT05273879 | Sklifosovsky Institute of Emergency Care | N/A |
| Recruiting | Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrt NCT06119542 | Istituto Ortopedico Rizzoli | — |
| Unknown | SynerFuse Spinal Fusion and Neuromodulation Proof of Concept Study NCT04054401 | SynerFuse, Inc | N/A |
| Terminated | Spine Registration Using 3D Scanning - Arise NCT05195593 | Advanced Scanners Inc. | — |
| Terminated | Does Prehabilitation Improve Outcomes in Patients Undergoing Complex Spine Fusion Surgery? NCT05034341 | University of Florida | N/A |
| Recruiting | A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain NCT05010148 | University of California, San Francisco | Phase 3 |
| Terminated | Spine Registration Using 3D Scanning NCT05195580 | Advanced Scanners Inc. | — |
| Completed | Risk Factors for Mechanical Failure After Spinal Fusion : an Observational Study NCT04983576 | Istituto Ortopedico Rizzoli | — |
| Completed | Optimization of a Tool for Predicting Postoperative Clinical Evolution After Lumbar Surgery NCT05166018 | Cortexx Medical Intelligence | N/A |
| Withdrawn | Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery NCT04421209 | Duke University | Phase 2 |
| Completed | Bone Marrow Clot for Posterior Lumbar Fusion NCT05936047 | Istituto Ortopedico Rizzoli | N/A |
| Recruiting | Personalized Spine Study Group (PSSG) Registry NCT04601363 | University of Colorado, Denver | — |
| Withdrawn | Minimally Invasive Surgery Techniques for One-level Degenerative Lumbar Deformities Correction NCT03908203 | Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan | N/A |
| Unknown | Allogeinic Bone Paste NCT04605120 | Biobank | N/A |
| Unknown | KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fu NCT04294004 | Kuros Biosurgery AG | Phase 2 |
| Active Not Recruiting | Artoss Prospective Spine Registry Outcomes NCT04439032 | Artoss Inc. | — |
| Completed | The Efficacy of Postoperative Analgesia of Gabapentin Plus Nefopam in the Spinal Surgery NCT04491786 | Gia Dinh People Hospital | N/A |
| Unknown | The OsteoStrand Plus Deformity Study NCT04629794 | SeaSpine, Inc. | N/A |
| Unknown | Prospective SPINE Registry NCT04176562 | Xtant Medical | — |
| Completed | Improved Rehabilitation After Spinal Surgery in Adolescents NCT04183049 | Nantes University Hospital | — |
| Completed | The Effect of Lordosis on Clinical Outcome After Spinal Fusion for One-level Degenerative Spondylolysthesis NCT04174144 | University Medical Centre Ljubljana | — |
| Completed | Impact of Body Habitus (Arm Span and Abdominal Girth) on Activities of Daily Living (ADL) NCT04037059 | Duke University | — |
| Recruiting | Abaloparatide vs. Placebo in Post-Menopausal Women and Abaloparatide in Men Receiving Initial Spinal Fusion Su NCT03841058 | Hospital for Special Surgery, New York | Phase 2 |
| Unknown | Lumbar Erector Spinae Plane Block for Back Surgery NCT03825198 | Dr M. B. Breebaart | Phase 3 |
| Completed | Physical Therapy Using Virtual Reality/Augmented Reality NCT03874507 | Stanford University | N/A |
| Terminated | Neurosurgical Transitional Care Programme NCT03593330 | Barts & The London NHS Trust | N/A |
| Completed | Comparison of GAP-score With Schwab-score NCT03859609 | Mohammad ARAB MOTLAGH | — |
| Unknown | Virtual Reality for Post-operative Pain Management NCT03584776 | Gillette Children's Specialty Healthcare | N/A |
| Terminated | The Effects of Dexmedetomidine Dose on Motor Evoked Potentials NCT03378973 | Hospital for Special Surgery, New York | Phase 4 |
| Unknown | Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion NCT03692845 | Assiut University | N/A |
| Terminated | Efficacy and Safety of Tranexamic Acid in Spinal Fusion Surgery NCT03425799 | Exela Pharma Sciences, LLC. | Phase 3 |
| Completed | Sufentanil NanoTab PCA System/15 mcg for Acute Post-Operative Pain in Vertebral Surgery: A Preliminary Investi NCT03459404 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Completed | Risk Factors of Second Surgery for Adjacent Segment Disease Following Anterior Cervical Discectomy and Fusion NCT03826329 | Taipei Veterans General Hospital, Taiwan | — |
| Recruiting | Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine S NCT03883022 | Taipei Veterans General Hospital, Taiwan | N/A |
| Completed | BMAC & Allograft vs BMP-2 NCT02924571 | NYU Langone Health | N/A |
| Completed | MagnetOs™ Granules vs. Autograft in Instrumented Posterolateral Spinal Fusion NCT03625544 | M.C. Kruyt, MD, PhD | N/A |
| Completed | Clinical and Radiological Investigation of a New Spinal Fixateur Interne (Ennovate®) NCT03550846 | Aesculap AG | — |
| Completed | Thromboelastography-Guided Fluid Management in Spinal Surgery NCT03999086 | Mayo Clinic | — |
| Completed | Study of Titanium-Coated PEEK Cages for Degenerative Disc Disease NCT03565224 | Aesculap AG | — |
| Unknown | Autologous Bone Marrow Concentrate in Elective Tranforaminal Lumbar Interbody Fusion Surgery NCT03793530 | Pei-Yuan Lee, MD | N/A |
| Unknown | Examining Effects of Spinal Fusion on Outcomes Following Total Hip Replacement NCT03240484 | Ottawa Hospital Research Institute | — |
| Completed | Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study. NCT03407560 | Istituto Ortopedico Rizzoli | N/A |
| Completed | Instr. vs. Non-instr. Posterolateral Spinal Fusion in Patients With Spinal Stenosis and Degenerative Listhesis NCT04166981 | Spine Centre of Southern Denmark | N/A |
| Completed | PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery NCT02985762 | Pacira Pharmaceuticals, Inc | Phase 1 |
| Completed | Early Postoperative Home Exercise Program After Cervical Spine Surgery NCT02720172 | Vanderbilt University Medical Center | N/A |
| Completed | The Effect of Oral Vitamin D Supplements on Fusion Outcome in Patients Receiving Elective Lumbar Spinal Fusion NCT05023122 | Show Chwan Memorial Hospital | N/A |
| Unknown | Galeazzi Spine Surgery RegistryGaleazzi Spine Registry: Prospective Study for Clinical Monitoring NCT03644407 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Unknown | Evaluation of Treatment Effect of Minimally Invasive Spinal Fusion Surgery NCT05190055 | Chi Mei Medical Hospital | N/A |
| Completed | Complementary and Alternative Medicine Interventions in Targeting Pain NCT04845334 | Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria | N/A |
| Completed | Alvimopan and Ileus in PSF NCT02218190 | Washington University School of Medicine | N/A |
| Completed | SSEP Fluctuations Due to Dexmedetomidine During Posterior Spine Fusion NCT03236727 | George Papanicolaou Hospital | Phase 3 |
| Withdrawn | Personalized Spine Study Group Registry NCT03843476 | Medicrea, USA Corp. | — |
| Completed | Effect of Intraoperative Allogeneic Blood Transfusion on Postoperative Pulmonary Complications NCT05661838 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Point of Care Testing in Pediatric Patients Undergoing Major Surgery NCT01742936 | Nationwide Children's Hospital | N/A |
| Completed | A Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fus NCT03274453 | NYU Langone Health | Phase 2 |
| Terminated | Evaluating the Role of Pregabalin in Reducing Opioid Requirement in Spinal Fusion Surgeries of Two or More Ver NCT03031340 | Montefiore Medical Center | Phase 3 |
| Completed | Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Trane NCT01136590 | Hospital Universitari Vall d'Hebron Research Institute | Phase 4 |
| Completed | Prevalence of Inadvertent Hyperventilation During Intraoperative Anesthetic Care NCT01235650 | Nationwide Children's Hospital | — |
| Completed | Effect of a Case Manager to Assist the Rehabilitation for Lumbar Spinal Fusion Patients. A Randomised Controll NCT03433443 | University of Aarhus | N/A |
| Completed | Intraoperative Disinfection by Pulse Irrigation With Povidone-Iodine Solution in Spine Surgery NCT03249363 | University of Rome Tor Vergata | N/A |
| Completed | Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF NCT00994656 | Children's Hospital of Philadelphia | — |
| Completed | Intrathecal Morphine Versus Epidural Extended Release Morphine for Pediatric Patients Undergoing Spinal Fusion NCT00880607 | University of Colorado, Denver | Phase 4 |
| Completed | Remifentanil Propofol Infusion in Pediatric Spinal Surgery NCT00761072 | Children's Hospital of Philadelphia | — |
| Completed | Bioactive Glass as Bone Graft Substitute in Operative Treatment of Bone - a 10 Years Follow-up Study NCT00935870 | Vivoxid Ltd | — |
| Completed | Use of Activated Recombinant FVII in Spinal Surgery NCT00102037 | Novo Nordisk A/S | Phase 2 |
| Completed | Use of Radiostereometric Analysis (RSA) Following Spinal Fusion Versus the DYNESYS Stabilization System NCT00152165 | State University of New York - Upstate Medical University | — |
| Completed | Use of Radiostereometric Analysis Beads (RSA) to Measure Motion in the Spine, Following Lumbar Spinal Surgery NCT00152152 | State University of New York - Upstate Medical University | — |