NCT06233617

Dexamethasone vs. Dexmedetomidine for ESPB in Pain Management After Spine Surgery

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Poznan University of Medical Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Effect of perineurial dexamethasone and dexmedetomidine on erector spinal plane block duration for spine surgery.

Detailed description

This study is proposed to explore the effect of perineurial Dexamethasone and Dexmedetomidine on erector spinal plane block duration for spine surgery. After spine surgery, patients need good analgesia. Peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe. The safety of local anaesthesia is essential due to the much lower toxicity threshold of local anaesthetics. An effective adjuvant, such as Dexamethasone or Dexmedetomidine, could allow for a higher dilution of local anaesthetics while maintaining and enhancing their analgesic effect. There is considerable research where intravenous and perineural dexamethasone and Dexmedetomidine use have been compared in adults. However, there is a massive lack of research regarding spine surgery and the Erector Spinae Plane Block. In this study, investigators compare perineural Dexamethasone and Dexmedetomidine. The investigator aims to find a dexamethasone or dexmedetomidine that covers the need for good pain relief and fast recovery postoperatively.

Conditions

• Spinal Fusion
• Spine Disease
• Spinal Stenosis
• Erector Spinae Plane Block

Interventions

Type	Name	Description
DRUG	0.9% Sodium Chloride Injection	biliteral administration of 20ml of 0,2% ropivacaine + 2ml 0.9% sodium chloride for the erector spine plane block
DRUG	Dexamethasone 4 Mg/mL Injectable Solution	biliteral administration of 20ml of 0,2% ropivacaine with 4mg Dexamethasone for the erector spine plane block
DRUG	Dexmedetomidine injection	biliteral administration of 20ml of 0,2% ropivacaine with 50ug Dexmedetomidine for the erector spine plane block

Timeline

• Start date: 2024-03-01
• Primary completion: 2025-03-01
• Completion: 2025-04-01
• First posted: 2024-01-31
• Last updated: 2024-04-29

Locations

1 site across 1 country: Poland