NCT04421209

Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery

• Status: Withdrawn
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if treatment with low-dose oral propranolol in the days before and after surgery decrease postoperative pain and improve pain scores.

Detailed description

This study is a randomized, double-blind, placebo controlled clinical trial.The main purpose of this study is to determine if postsurgical opioid use and pain scores are decreased with oral Propranolol treatment. The treatment period will last for six days and the observation period will last for three months. Effectiveness of treatment will be assessed by means of post-operative opioid consumption as primary outcome measure.

Conditions

• Lumbar Disc Disease
• Spinal Fusion
• Degenerative Disc Disease

Interventions

Type	Name	Description
DRUG	Propranolol Hcl 40mg Tab	40mg PO BID for the three days prior to surgery, 40mg PO BID the day of surgery and on post-op days 1 and 2.
DRUG	Placebo oral tablet	Placebo tablets administered with the same schedule of Propranolol tablets

Timeline

• Start date: 2020-12-01
• Primary completion: 2021-06-30
• Completion: 2021-09-30
• First posted: 2020-06-09
• Last updated: 2021-03-16

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study