| Not Yet Recruiting | Biologic Injection For Adults With Lumbar Disc Herniation NCT07386548 | Weill Medical College of Cornell University | N/A |
| Recruiting | Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury NCT06438471 | EicOsis Human Health Inc. | Phase 1 |
| Not Yet Recruiting | Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degene NCT07017634 | CGBio Inc. | Phase 3 |
| Not Yet Recruiting | Assessing Safety of Cervical Spine Fusion With NMP® NCT07245940 | Red Rock Regeneration Inc. | — |
| Recruiting | A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomat NCT07254806 | DiscGenics, Inc. | Phase 3 |
| Enrolling By Invitation | Retrospective Analysis of Patients Implanted With 2 Levels of Prodisc® C Vivo Devices NCT07370493 | Centinel Spine | — |
| Not Yet Recruiting | Study to Determine the Safety and Tolerability of TG-C in Subjects with Back Pain Due to Degenerative Disc Dis NCT06144970 | Kolon TissueGene, Inc. | Phase 1 |
| Withdrawn | Effect of RECK in Posterior Spinal Fusion NCT06447194 | University of Maryland, Baltimore | Phase 1 / Phase 2 |
| Withdrawn | Stem Cells vs. Steroids for Discogenic Back Pain NCT04735185 | Johns Hopkins University | N/A |
| Enrolling By Invitation | Virtuos Bone Graft in Lumbar Fusion NCT06686017 | Orthofix Inc. | — |
| Recruiting | Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerat NCT06778447 | VIVEX Biologics, Inc. | N/A |
| Recruiting | Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mix NCT04679844 | Kuros Biosurgery AG | N/A |
| Recruiting | LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF) NCT06462729 | Locate Bio Pty Ltd | Phase 1 / Phase 2 |
| Recruiting | Conduit Cages and Fibergraft BG Putty NCT06704919 | Nitin Agarwal | — |
| Recruiting | ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated NCT06615505 | VIVEX Biologics, Inc. | Phase 2 |
| Recruiting | Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two- NCT06485206 | Highridge Medical | N/A |
| Recruiting | Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low NCT06325566 | Mesoblast, Ltd. | Phase 3 |
| Enrolling By Invitation | Study to Assess the Performance of MagnEtOs Flex Matrix Compared to Cellular Allograft NCT06415123 | Research Source | — |
| Recruiting | MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-le NCT05037968 | Kuros Biosurgery AG | N/A |
| Recruiting | Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chroni NCT06053242 | Creative Medical Technology Holdings Inc | Phase 1 / Phase 2 |
| Completed | Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery NCT06199999 | Rashmi Mueller | Phase 2 |
| Not Yet Recruiting | Clinical Outcome Measure at Stryker Spine NCT06226272 | Stryker Spine | — |
| Withdrawn | Postmarket Clinical Follow-Up Study on Arcadius XP L® Interbody Fusion Device NCT05944081 | Aesculap AG | — |
| Recruiting | Evaluation of NB1 Bone Graft Following Lumbar Interbody Arthrodesis NCT03810573 | Bone Biologics Corp | N/A |
| Enrolling By Invitation | Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion NCT06000319 | Induce Biologics USA Inc. | — |
| Unknown | Discure Technologies Feasibility Study for DDD NCT06127745 | Discure Technologies Ltd. | N/A |
| Active Not Recruiting | A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion NCT06115512 | Angitia Biopharmaceuticals | Phase 3 |
| Completed | Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion NCT05972616 | Induce Biologics USA Inc. | — |
| Recruiting | Spine Unit Modelling Coupled With hIgh Throughput Analysis (SUIT) NCT06490887 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Enrolling By Invitation | Adjacent Level Anterior Cervical Fusion: SeaSpine Shoreline Versus Removal of Previously Implanted Plate and R NCT06415136 | Research Source | — |
| Recruiting | Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty NCT05701059 | University of California, Los Angeles | — |
| Unknown | Retrospective Study With Patients Treated With STALIF® C or M and Ti or FLX Implants for 1 and 2 Levels NCT05610397 | Centinel Spine | — |
| Recruiting | Investigation of DEXA-C Anterior Cervical Interbody System NCT05883436 | Aurora Spine and Pain | N/A |
| Enrolling By Invitation | Long-Term Assessment of the Safety and Performance of the NuVasive Simplify Disc at Two Levels NCT05691231 | NuVasive | — |
| Recruiting | Evaluating the Efficacy of Para-discal Infiltration in Patients With Lateralized MODIC 1 Inflammatory Disc Dis NCT05615597 | University Hospital, Montpellier | N/A |
| Terminated | Comparative Analysis of Virtuos and Autograft in Lumbar Fusion NCT05614284 | Orthofix Inc. | N/A |
| Recruiting | Comparison of Radiographic Fusion Rate and Clinical Outcome of ALIF and XLIF Performed With Either Recombinant NCT05238740 | Lindenhofgruppe AG | N/A |
| Active Not Recruiting | VIA Disc Nucleus Pulposus Older Patients Pilot NCT05412277 | VIVEX Biologics, Inc. | N/A |
| Recruiting | "Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2) NCT05508360 | Spinal Stabilization Technologies | N/A |
| Completed | Retrospective Modulus ALIF Study NCT05566704 | NuVasive | — |
| Enrolling By Invitation | Posterior Cervical Fixation Study NCT04770571 | NuVasive | — |
| Unknown | OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study NCT05405374 | Bioventus LLC | N/A |
| Recruiting | Trial for Treating Painful Degenerative Disc Disease NCT05287867 | Regenexx, LLC | N/A |
| Recruiting | Carbofix Pedicle Screw System: Evaluation of the Clinical and Radiographic Outcomes of the Use of a Carbon Fib NCT06209684 | Istituto Ortopedico Rizzoli | N/A |
| Unknown | Intradiscal and Intra-articular Injection of Autologous Platelet-Rich-Plasma (PRP) in Patients With Lumbar Deg NCT04816747 | Stylianos Kapetanakis | Phase 3 |
| Recruiting | OssDsign® Spine Registry Study ("Propel") NCT05329129 | OssDsign | — |
| Active Not Recruiting | Long-term Assessment of the Safety and Performance of the NuVasive Simplify Disc NCT05258435 | NuVasive | — |
| Recruiting | Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery NCT05029726 | John O'Toole | Phase 4 |
| Completed | Study of the ReGelTec HYDRAFIL System NCT04984629 | ReGelTec, Inc. | N/A |
| Unknown | Safety, Radiological and Patient Reported Outcomes of i-FACTOR+ Matrix Bone Graft Device - A Canadian, Multice NCT05144126 | CeraPedics, Inc | N/A |
| Not Yet Recruiting | Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions NCT03390920 | R3 Stem Cell | N/A |
| Withdrawn | Post Market Observational Trial for the PerQdisc Nucleus Replacement Device NCT05105490 | Spinal Stabilization Technologies | — |
| Active Not Recruiting | VIA Disc NP Pilot for Patients With Symptomatic Degenerated Discs NCT05201287 | VIVEX Biologics, Inc. | N/A |
| Terminated | Interbody Systems: Post Market Clinical Follow-up Study NCT04911257 | K2M, Inc. | — |
| Active Not Recruiting | Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages NCT05182489 | Ohio State University | N/A |
| Terminated | Cervical Interbody Fusion Device Patient Registry NCT05114356 | Restor3D | — |
| Unknown | Clinical and Radiographic Outcomes of TLIF w/3D Printed Cellular Implant NCT05023733 | Farhan Karim | — |
| Completed | Intra-discal Injection of Platelet-rich Plasma (PRP) Enriched With Exosomes in Chronic Low Back Pain NCT04849429 | Dr. Himanshu Bansal Foundation | Phase 1 |
| Completed | TLIF Osteo3 ZP Putty Study (Also Known as the TOP Fusion Study) NCT05114135 | OssDsign | N/A |
| Completed | Post Marketing Study of MagnetOs Putty Compared to Local Autograft in Patients Undergoing Posterolateral Lumba NCT04679896 | Kuros Biosurgery AG | N/A |
| Unknown | Protocol for an Analytical Study With Microbiological, Phenotypic, Genotypic and Multiomics Techniques NCT05090553 | Gaffree & Guinle Universitary Hospital | N/A |
| Recruiting | Post-Market Clinical Follow-Up Study on the Safety and Performance of Ennovate® Cervical NCT05296889 | Aesculap AG | — |
| Active Not Recruiting | Rate of Bony Fusion Using NanoBone® Synthetic Bone Graft Versus Local Autologous Bone Graft. NCT04615260 | Artoss Inc. | N/A |
| Completed | A Clinical Study to Evaluate Safety and Performance of PEEK-OPTIMA™ HA Enhanced. NCT04416321 | Invibio Ltd | N/A |
| Unknown | A Safety Study on Posterior Pedicle Screw System NCT05821920 | Medacta International SA | — |
| Recruiting | The SPINUS II Study: Spinal Fusion for Multilevel SPECT/CT Positive Lumbar Degeneration NCT04893720 | Military University Hospital, Prague | — |
| Active Not Recruiting | Anterior Cervical Disectomy And Fusion Using The Tritanium® C Anterior Cervical Cage For One Or Two-Levels NCT04214535 | Corewell Health East | N/A |
| Completed | XLIF Decade Plate System Study NCT04689880 | NuVasive | — |
| Unknown | MySpine MC Versus MySpine Standard NCT05846477 | Medacta International SA | — |
| Unknown | Orthokine Therapy in Lumbar Degenerative Disease NCT04734327 | Sutherland Medical Center | Phase 4 |
| Recruiting | OssiMend BA in Posterolateral Instrumented Lumbar Fusion NCT04775537 | Collagen Matrix | — |
| Completed | Clinical Decision-Making and Virtual Reality Exercise NCT05375201 | National Taiwan University Hospital | N/A |
| Completed | A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease NCT05574543 | Angitia Biopharmaceuticals | Phase 1 / Phase 2 |
| Withdrawn | Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery NCT04421209 | Duke University | Phase 2 |
| Withdrawn | Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease NCT04128852 | Kuros Biosurgery AG | N/A |
| Recruiting | Personalized Spine Study Group (PSSG) Registry NCT04601363 | University of Colorado, Denver | — |
| Unknown | Lumbar Transforaminal Anterior Epidural Steroid Injections in Discogenic Low Back Pain NCT04930211 | Marmara University | N/A |
| Unknown | Idys™ TLIF 3DTi Post Market Clinical Follow-up NCT04584619 | Clariance | — |
| Enrolling By Invitation | Lumbar Interbody Implant Study NCT04418830 | NuVasive | — |
| Unknown | Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease NCT04727385 | Gelmetix | N/A |
| Recruiting | Preventive Effect of Limited Decompression on Adjacent Segment Following Posterior Lumbar Interbody Fusion NCT04469387 | Peking University Third Hospital | N/A |
| Unknown | KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fu NCT04294004 | Kuros Biosurgery AG | Phase 2 |
| Recruiting | ACDF Using Structural Allograft vs. Tritanium C NCT04388332 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | N/A |
| Completed | TXA in Spinal Fusion NCT04272606 | Catherine R. Olinger | Phase 2 |
| Unknown | SPIRA™-A 3D and HCT/p DBM vs. Medtronic Divergent™-L/Perimeter™ and Recombinant BMP-2 NCT04566874 | Camber Spine Technologies | N/A |
| Enrolling By Invitation | Cervical Interbody Implant Study NCT04689854 | NuVasive | — |
| Terminated | Single Position Spine Surgery Registry NCT04839783 | Spine and Scoliosis Research Associates | — |
| Withdrawn | The Efficacy of Continuous Cold-Therapy on Postoperative Pain and Narcotics Use Following Spinal Fusion NCT03640338 | Rush University Medical Center | N/A |
| Completed | Modulus in XLIF Study NCT04418817 | NuVasive | — |
| Active Not Recruiting | Study of Posterior Cervical Stabilization System (PCSS) as Part of Circumferential Fusion to Treat Multilevel NCT04229017 | Providence Medical Technology, Inc. | N/A |
| Completed | Adjacent Segment Disease After Anterior Cervical Decompression Surgery NCT04320043 | Zuyderland Medisch Centrum | — |
| Unknown | Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions NCT04112550 | The Methodist Hospital Research Institute | Phase 1 |
| Completed | MLX/XLX ACR Expandable Lumbar Interbody Implants NCT04420143 | NuVasive | — |
| Unknown | 3D-printed Porous Titanium Alloy Cages Versus PEEK Cages in Patients With Osteoporosis NCT04086784 | Peking University Third Hospital | — |
| Completed | Quintex® Follow-up After One Year Minimum NCT04489394 | Aesculap AG | — |
| Active Not Recruiting | PMCF Neo Pedicle Screw and Cage Systems NCT03956537 | Neo Medical SA | — |
| Completed | Retrospective Review of Integrity Implants FlareHawk® for Lumbar Fusion NCT04057235 | Integrity Implants Inc. | — |
| Terminated | Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nuclectomy NCT04141098 | Spinal Stabilization Technologies | N/A |
| Unknown | Post-Market Clinical Follow-up Study of A-SPINE's Products NCT04848376 | A-Spine Asia Co., Ltd. | — |
| Completed | Clinical and Radiological Outcomes of Posterior Cervical Fusion with Medtronic Infinity Occipitocervical-Upper NCT04056520 | Ohio State University | — |
| Completed | Stabilizing Training in Degenerative Disc Disease NCT04119466 | Wroclaw University of Health and Sport Sciences | N/A |
| Terminated | Brain Imaging of Pain-Related Processing and Structural Properties in Disc Degenerative Disease NCT04934917 | Karolinska Institutet | — |
| Withdrawn | A Study Evaluating 3-Level OLIF Spine Fusion NCT03896347 | Elutia Inc. | — |
| Completed | Cortical Bone Trajectory With Patient Guide NCT05844358 | Medacta International SA | — |
| Completed | Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degener NCT03955315 | DiscGenics, Inc. | Phase 1 |
| Completed | Fibergraft Interbody Fusion Retrospective NCT03898232 | Bone and Joint Clinic of Baton Rouge | — |
| Recruiting | LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant NCT04631133 | BACKBONE | — |
| Unknown | A Prospective Study of Clinical Outcomes Following a Single Intradiscal Injection of Bone Marrow Aspirate Conc NCT03912454 | Bone and Joint Clinic of Baton Rouge | N/A |
| Completed | Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease NCT03733626 | Corewell Health East | N/A |
| Terminated | Safety Study for An Artificial Disc Nucleus Replacement to Treat Chronic Low Back Pain NCT04004156 | Spinal Stabilization Technologies | N/A |
| Terminated | A Comparison of Stryker's Tritanium Posterior Lumbar Cage and PEEK Implant NCT03817606 | Riverside Medical Center | N/A |
| Completed | Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT NCT03884283 | Prosidyan, Inc. | N/A |
| Completed | Clinical Evaluation of Fortilink® TETRAfuse® Interbody Fusion Device in Subjects With Degenerative Disc Diseas NCT03761563 | Xtant Medical | — |
| Terminated | Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery NCT04007094 | Ohio State University | N/A |
| Active Not Recruiting | The European Robotic Spinal Instrumentation (EUROSPIN) Study NCT03398915 | Marc Schröder | — |
| Unknown | NanoFUSE® PL Gutter PMCF NCT03751943 | NanoFUSE Biologics, LLC | Phase 4 |
| Withdrawn | ACDF Comparison Trial NCT03187171 | Duke University | N/A |
| Completed | GDS Muscle and Articulation Chain Treatment for Chronic LBP and Spinal Stenosis NCT04436003 | The Hospital of Vestfold | N/A |
| Terminated | Autologous, Culture-Expanded Mesenchymal Stromal Cells for Degenerative Disc Disease NCT03461458 | Mayo Clinic | Phase 1 |
| Completed | FLXfitTM 15 TLIF Interbody Fusion Device NCT04208048 | Rush University Medical Center | — |
| Enrolling By Invitation | The Course of Hip Flexion Weakness Following LLIF or ALIF NCT04204135 | Rush University Medical Center | — |
| Enrolling By Invitation | Advanced Materials Science in XLIF Study NCT03649490 | NuVasive | — |
| Withdrawn | Peri-Incisional Drug Injection in Lumbar Spine Surgery NCT03513445 | University of Minnesota | Phase 3 |
| Withdrawn | Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion NCT03327272 | Rush University Medical Center | Phase 3 |
| Completed | ViBone in Cervical and Lumbar Spine Fusion NCT03425682 | Elutia Inc. | — |
| Active Not Recruiting | P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion With Instrumentation NCT03438747 | CeraPedics, Inc | N/A |
| Completed | Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebr NCT03347708 | DiscGenics, Inc. | Phase 1 |
| Completed | AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain NCT03263611 | AnGes, Inc. | Phase 1 |
| Unknown | A Comparative Study Between Mechanical and a Viscoelastic Disc Prosthesis in the Lumbar Spine NCT03716947 | Karolinska Institutet | N/A |
| Recruiting | Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery NCT04467944 | Peking University Third Hospital | — |
| Completed | The SPINUS I Study: Spinal Fusion for a Single Level SPECT/CT Positive Lumbar Degenerative Disc Disease NCT04876586 | Military University Hospital, Prague | — |
| Completed | Retest-reliability and At-home-assessment Feasibility of the 5R-STS NCT03321357 | Bergman Clinics | — |
| Completed | The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy NCT03303300 | Marc Schröder | — |
| Withdrawn | Efficacy of Using Solum IV and BMC With GFC in TLIF NCT03223701 | Seton Healthcare Family | Phase 4 |
| Unknown | Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain NCT03709901 | VIVEX Biologics, Inc. | N/A |
| Terminated | A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single In NCT03246399 | Biosplice Therapeutics, Inc. | Phase 1 |
| Unknown | Effectiveness and Safety of Mesenchymal Stem Cell (MSC) Implantation on Degenerative Discus Disease Patients NCT04499105 | Ahmad Jabir Rahyussalim | Phase 2 |
| Withdrawn | Stand-Alone Cage Verus Anterior Plating for Anterior Cervical Discectomy and Fusion. NCT03312192 | Rush University Medical Center | N/A |
| Completed | Study Using the CervicalStim Device Following Cervical Fusion NCT03177473 | Orthofix Inc. | — |
| Completed | BIO4 Clinical Case Study: Cervical Spine NCT03077204 | Seton Healthcare Family | Phase 4 |
| Unknown | Burst Biologics Spinal Fusion Registry NCT03064802 | Burst Biologics | — |
| Withdrawn | Patient Outcomes Using an Expandable Spacer NCT03162666 | Globus Medical Inc | — |
| Unknown | Post-market Surveillance Study of FLXfit™ TLIF Interbody Fusion Device NCT02805985 | Expanding Orthopedics Ltd. | N/A |
| Unknown | Trinity Elite in Lumbar Fusion NCT02969616 | Orthofix Inc. | — |
| Terminated | AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY NCT02704689 | Stryker Spine | N/A |
| Completed | Interbody Spacers With map3® Cellular Allogeneic Bone Graft in Anterior or Lateral Lumbar Interbody Fusion NCT02628210 | RTI Surgical | N/A |
| Completed | Safety and Efficacy of the CarboClear Pedicle Screw System NCT02626624 | CarboFix Orthopedics Ltd. | N/A |
| Completed | Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease NCT03484403 | Dallas VA Medical Center | N/A |
| Unknown | Study of Nucel for One and Two Level Lumbar Interbody Fusion NCT02808234 | Organogenesis | N/A |
| Terminated | OLIF25™ /OLIF51™ Study NCT02657421 | Medtronic Spinal and Biologics | — |
| Completed | New Robotic Assistance System for Spinal Fusion Surgery NCT02558621 | KB Medical SA | N/A |
| Completed | Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants W NCT02412735 | Mesoblast, Ltd. | Phase 3 |
| Completed | Evaluation of the Effectiveness of Spa Treatment in Swieradow Zdroj With Special Regard to the Action of Radon NCT03274128 | Wroclaw Medical University | N/A |
| Unknown | Efficacy of Intradiscal Injection of Viable Placental Tissue Extract in Subjects With One or Two Level, Sympto NCT02379689 | Semmes-Murphey Foundation | N/A |
| Terminated | Clinical Evaluation of GENEX® DS in Instrumented Posterolateral Fusion NCT02317185 | Spine Wave | — |
| Completed | Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion NCT02205138 | Bone Therapeutics S.A | Phase 2 |
| Terminated | Evaluation of Fusion Rate Using K2M VESUVIUS® Demineralized Fibers With K2M EVEREST® Spinal System NCT02064855 | K2M, Inc. | — |
| Withdrawn | Enhanced Metal Reduction Techniques for Definitive CT Scanning to Assess Spinal Fusion With TM-Ardis NCT02170558 | Zimmer Biomet | — |
| Terminated | Comparison of Complication Rates Between Lateral Approaches to the Lumbar Spine NCT02068729 | K2M, Inc. | — |
| Unknown | Restore CLINICAL TRIAL NCT01609374 | Spinal Kinetics | N/A |
| Completed | Facet Wedge Post Market Study NCT02203448 | Synthes GmbH | — |
| Completed | Annex™ Adjacent Level System for Treatment of Adjacent Level Disease NCT02108249 | Spine Wave | — |
| Completed | Adipose Cells for Degenerative Disc Disease NCT02097862 | Bioheart, Inc. | N/A |
| Completed | Post-Market Surveillance Study of the TM Ardis Interbody Fusion System NCT02429908 | Zimmer Biomet | Phase 4 |
| Withdrawn | Personalized Spine Study Group Registry NCT03843476 | Medicrea, USA Corp. | — |
| Completed | Safety and Efficacy of the CarboFix Pedicle Screw System NCT02039232 | CarboFix Orthopedics Ltd. | N/A |
| Completed | A Retrospective Study Using CALIBER® TLIF Expandable Spacer in the Treatment of DDD: 2 Year Follow-up. NCT02388022 | Globus Medical Inc | — |
| Completed | Retrospective/Prospective Data Collection on the LDR ROIA Interbody Fusion Device With VerteBRIDGE Plating NCT02104141 | LDR Spine USA | — |
| Unknown | The Prevalence of Bone Degenerative Diseases in Beijing - a Cross-sectional Study NCT03086109 | Beijing Jishuitan Hospital | — |
| Completed | Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating NCT02104167 | LDR Spine USA | — |
| Terminated | Utilization of Autologous Mesenchymal Cells in Posterolateral Spinal Fusion in Degenerative Spine Disease NCT03827096 | Bioinova, s.r.o. | Phase 1 / Phase 2 |
| Terminated | Multicenter Study of the Avenue L Interbody Spinal Fusion System Using VerteBRIDGE Plating and Posterior Fixat NCT02068768 | LDR Spine USA | — |
| Completed | Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) NCT01860417 | Red de Terapia Celular | Phase 1 / Phase 2 |
| Completed | Retrospective Multicenter Clinical Evaluation of Complications for Single or Multilevel VEO® Lateral Access an NCT01878149 | Baxano Surgical, Inc. | — |
| Unknown | Prospective Study To Assess The Safety and Efficacy of the PROW LIF Procedure NCT01850537 | NLT Spine | N/A |
| Completed | Assessment of nanOss Bioactive 3D in the Posterolateral Spine NCT01829997 | Pioneer Surgical Technology, Inc. | N/A |
| Completed | ArcadiusXP L Post Market Clinical Follow-Up NCT01895426 | Aesculap AG | — |
| Suspended | Clinical and Radiological Outcomes of Oblique Lateral Lumbar Interbody Fusion NCT03726190 | Tristate Brain and Spine Institute | — |
| Unknown | Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft NCT01746212 | Kansas Joint and Spine Institute | — |
| Terminated | A Study Comparing the Safety and Effectiveness of Cartilage Cell Injected Into the Lumbar Disc as Compared to NCT01771471 | ISTO Technologies, Inc. | Phase 2 |
| Completed | Study of an Expandable Interbody Device for the Lumbar Spine NCT02075554 | Globus Medical Inc | N/A |
| Terminated | RAMP Study: A Study Comparing Two Lumbar Fusion Procedures NCT01716182 | Baxano Surgical, Inc. | — |
| Completed | Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis NCT01455805 | Spinal Simplicity LLC | N/A |
| Completed | Safety, Tolerability and Efficacy of YH14618 in Patients With Degenerative Disc Disease NCT01526330 | Yuhan Corporation | Phase 1 / Phase 2 |
| Completed | Outcome Analysis for Minimally Invasive Spine Surgery and Navigation NCT01751841 | Weill Medical College of Cornell University | — |
| Completed | INDEPENDENCE Spacer for Lumbar Fusion NCT02299323 | Globus Medical Inc | — |
| Completed | Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain NCT01290367 | Mesoblast, Ltd. | Phase 2 |
| Completed | PEEK and Allograft Spacers Evaluation in Spinal Fusion Surgeries NCT01406405 | Justin Parker Neurological Institute | — |
| Withdrawn | Lumbar Degenerative Disc Disease Treatment With Bone Marrow Autologous Mesenchymal Stem Cells (MSV) NCT02440074 | Red de Terapia Celular | Phase 1 / Phase 2 |
| Completed | Intervertebral Disc Augmentation With Minimally Invasive Surgical Procedure NCT01442922 | University of Florida | — |
| Terminated | Effectiveness of Lumbar Fusion When NanOss Bioactive Is Used With Posterolateral Gutter Fusions NCT01452516 | Pioneer Surgical Technology, Inc. | N/A |
| Terminated | Clinical Outcomes of Lumbar Degenerative Disc Disease in Active-Duty U.S. Service Personnel NCT01028300 | Synthes USA HQ, Inc. | N/A |
| Terminated | Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System NCT01011816 | Spinal Restoration, Inc. | Phase 3 |
| Completed | Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spin NCT01968993 | Pioneer Surgical Technology, Inc. | N/A |
| Completed | A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerabili NCT01124006 | DePuy Spine | Phase 2 |
| Withdrawn | Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF) NCT01016314 | Zimmer Biomet | N/A |
| Completed | An Evaluation of Interlaminar Lumbar Instrumented (ILIF™) NCT01019057 | NuVasive | — |
| Completed | Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion NCT00996073 | Mesoblast, Ltd. | Phase 2 |
| Terminated | Bone Graft Materials Observational Registry NCT00974623 | Baxter Healthcare Corporation | — |
| Completed | Trinity Evolution in Posterior or Transforaminal Lumbar Interbody Fusion (PLIF/TLIF) NCT00965380 | Orthofix Inc. | — |
| Completed | Trinity Evolution in Anterior Cervical Disectomy and Fusion (ACDF) NCT00951938 | Orthofix Inc. | — |
| Completed | Actifuse ABX Versus INFUSE in Posterolateral Instrumented Lumbar Fusion NCT01018771 | Baxter Healthcare Corporation | N/A |
| Completed | XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) NCT00927238 | NuVasive | Phase 3 |
| Completed | Osteocel® Plus in Posterior Lumbar Interbody Fusion (PLIF) NCT00941980 | NuVasive | — |
| Completed | Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF) NCT00947583 | NuVasive | — |
| Completed | Osteocel® Plus in eXtreme Lateral Interbody Fusion (XLIF®) NCT00948532 | NuVasive | — |
| Completed | Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms NCT01502644 | Brigham and Women's Hospital | Phase 4 |
| Completed | Maverick Total Disc Replacement in a 'Real World' Patient Population NCT01338493 | Medtronic Spinal and Biologics | — |
| Completed | Trial Evaluating the Safety and Effectiveness of NUBAC™ Disc Arthroplasty NCT00931515 | Pioneer Surgical Technology, Inc. | N/A |
| Completed | Evaluation of Spa Medicine on the Example of Comprehensive Therapy in the Spa Resort Przerzeczyn Zdroj NCT03405350 | Wroclaw Medical University | N/A |
| Unknown | Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD NCT00798239 | BioSurface Engineering Technologies, Inc | Phase 1 / Phase 2 |
| Unknown | Pilot Study to Assess Safety/Preliminary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (D NCT00798902 | BioSurface Engineering Technologies, Inc | Phase 1 / Phase 2 |
| Withdrawn | Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion NCT00810212 | Mesoblast, Ltd. | Phase 1 / Phase 2 |
| Completed | Evaluate Effectiveness of the Biomet Lumbar Spinal Fusion System NCT00758719 | Zimmer Biomet | — |
| Completed | Fusion Assessment Clinical Trial NCT00736398 | Flexuspine, Inc. | — |
| Completed | Intradiscal rhGDF-5 Phase I/II Clinical Trial NCT00813813 | DePuy Spine | Phase 1 / Phase 2 |
| Terminated | Clinical Outcomes of the Trinica(R) Anterior Lumbar Plate: Fixed Screws vs. Variable Screws NCT00762723 | Zimmer Biomet | N/A |
| Completed | Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fus NCT00549913 | Mesoblast, Ltd. | Phase 1 / Phase 2 |
| Completed | INFUSE® Bone Graft/ PEEK Interbody Spacer/ Anterior Cervical Plate Pivotal Clinical Trial NCT00485173 | Medtronic Spinal and Biologics | N/A |
| Completed | Actifuse ABX Versus INFUSE in Posterolateral Instrumented Lumbar Fusion (PLIF) With Interbody Fusion NCT01013389 | Baxter Healthcare Corporation | N/A |
| Completed | Activ C European Multicenter Study NCT02492724 | Aesculap AG | — |
| Completed | A Pilot Study to Evaluate an Osteogenic Protein 1 (OP-1) Putty Spinal System and an Autograft Spinal System NCT00678171 | Olympus Biotech Corporation | N/A |
| Completed | Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease NCT00589797 | Aesculap Implant Systems | N/A |
| Completed | LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE NCT00389597 | LDR Spine USA | N/A |
| Completed | Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease NCT00316121 | Advanced Technologies and Regenerative Medicine, LLC (ATRM) | Phase 3 |
| Completed | Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease NCT00443547 | Synthes USA HQ, Inc. | — |
| Terminated | Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix NCT00254852 | Exactech | N/A |
| Completed | rhBMP-2/CRM/CD HORIZON® Spinal System Pilot Study (2-Level) NCT01491568 | Medtronic Spinal and Biologics | N/A |
| Terminated | Advanced MR Imaging in Patients With Painful, Degenerative Disc Disease: A Pilot Study NCT00706459 | University of California, San Francisco | — |
| Completed | CHARITE™ vs. ALIF 5-Year Follow-up NCT00215332 | DePuy Spine | — |
| Terminated | Kineflex Artificial Disc System to Treat Degenerative Disc Disease (DDD) NCT00292292 | SpinalMotion | N/A |
| Completed | Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease NCT00165893 | Emory University | Phase 4 |
| Completed | Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc) NCT00726284 | Zimmer Biomet | — |
| Completed | Disc Prosthesis Versus Multidisciplinary Rehabilitation NCT00394732 | Ullevaal University Hospital | N/A |
| Completed | TELAMON P™ Implant/INFUSE® Bone Graft/CD HORIZON® Spinal System Pilot Study NCT01491516 | Medtronic Spinal and Biologics | N/A |
| Completed | INFUSE® Bone Graft and MASTERGRAFT® Granules With CD HORIZON® for Posterolateral Lumbar Fusion in Patients Wit NCT01491542 | Medtronic Spinal and Biologics | N/A |
| Completed | Percutaneous Minimal Invasive Pedicular Screw and Rod Insertion in Circumferential Lumbar Fusion NCT01513577 | Northern Orthopaedic Division, Denmark | N/A |
| Completed | rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study NCT00707265 | Medtronic Spinal and Biologics | Phase 3 |
| Completed | Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion. NCT00215319 | DePuy Spine | Phase 3 |
| Terminated | Pivotal Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients With Sympto NCT01494493 | Medtronic Spinal and Biologics | N/A |
| Completed | Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal Instability NCT00726310 | Zimmer Biomet | — |
| Completed | CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease NCT00215306 | DePuy Spine | Phase 3 |
| Completed | Clinical Study of rhBMP-2/BCP With the TSRH® Spinal System for Posterolateral Lumbar Fusion in Patients With D NCT01494454 | Medtronic Spinal and Biologics | N/A |
| Completed | Pilot Study of rhBMP/BCP With or Without the TSRH® Spinal System for Posterolateral Lumbar Fusion in Patients NCT01494441 | Medtronic Spinal and Biologics | N/A |
| Terminated | A Pivotal Study of rhBMP-2/ACS/INTER FIX™ Device for Posterior Lumbar Interbody Fusion in Patients With Degene NCT01491464 | Medtronic Spinal and Biologics | N/A |
| Completed | A Pilot Study of rhBMP-2/ACS With the INTERFIX™ Device for the AnteriorLumbar Interbody Fusion in Patients Wit NCT01491451 | Medtronic Spinal and Biologics | N/A |
| Completed | A Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Degenerat NCT01491425 | Medtronic Spinal and Biologics | N/A |
| Completed | Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Symptomatic NCT01491386 | Medtronic Spinal and Biologics | N/A |
| Completed | Patient Outcomes Evaluation of the EBI Vuelock™ Anterior Cervical Plate System NCT00726128 | Zimmer Biomet | — |
| Completed | A Pilot Study of rhBMP-2/ACS/Allograft Bone Dowel for Anterior Lumbar Interbody Fusion in Patients With Sympto NCT01494428 | Medtronic Spinal and Biologics | N/A |
| Completed | Pilot Study of rhBMP-2/BCP in Patients With Spinal Degeneration With Instability Requiring Surgical Fusion NCT01495234 | Medtronic Spinal and Biologics | N/A |