| Not Yet Recruiting | Dose Dependent Steroid Injections NCT07494136 | University of Miami | Phase 4 |
| Recruiting | FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herni NCT07418944 | Helsinki University Central Hospital | N/A |
| Not Yet Recruiting | The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment Suc NCT07367191 | Marmara University | — |
| Not Yet Recruiting | Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Relate NCT07373808 | Universidad Complutense de Madrid | N/A |
| Not Yet Recruiting | Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of NCT07377357 | Universidad Complutense de Madrid | N/A |
| Recruiting | Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopa NCT07264270 | Consano Bio | Phase 1 |
| Recruiting | A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE NCT07125027 | National University of Natural Medicine | N/A |
| Completed | Neurodynamic Moblization Versus Mulligan on Pain and Functional Abilities in Patients With Chronic Discogenic NCT07050108 | Cairo University | N/A |
| Not Yet Recruiting | Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforami NCT07080307 | Marmara University | — |
| Completed | Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief NCT06947785 | Riphah International University | N/A |
| Completed | Ultrasonographic Evaluation of the Sciatic Nerve in Patients With Piriformis Syndrome NCT06783439 | Istanbul University - Cerrahpasa | — |
| Recruiting | Effects of SSMC With and Without Myofascial Release in Patients With Sciatica NCT06696898 | Riphah International University | N/A |
| Recruiting | Effects of Myofacial Release Technique and Sciatic Nerve Slider Technique in Sciatica NCT06536829 | Riphah International University | N/A |
| Active Not Recruiting | Comparative Effects of Sciatic Nerve Flossing and Active Release Technique in Cyclists With Sciatica NCT06827574 | Riphah International University | N/A |
| Completed | Effectiveness of Intravascular Laser Therapy on Sleep Quality in Patients With Chronic Low Back Pain: A Random NCT06755593 | Le Hoang Minh Quan | N/A |
| Completed | The Effect of Early MSAT Treatment on Sciatica Caused by Traffic Accidents. NCT06179901 | Jaseng Medical Foundation | N/A |
| Completed | Non-surgical Spinal Decompression in Patients With Chronic Low Back Pain NCT06275750 | Hospital Civil de Guadalajara | N/A |
| Completed | Effect of Sciatic Nerve Slider Technique in Different Positions in Low Back Pain Patients NCT05907356 | European University of Lefke | N/A |
| Completed | Effects of Pilates Exercises and Neural Dynamic Mobilization in Sciatica Patients NCT05959317 | Riphah International University | N/A |
| Completed | Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain NCT05022121 | University of Minnesota | N/A |
| Terminated | Spine Registration Using 3D Scanning - Arise NCT05195593 | Advanced Scanners Inc. | — |
| Completed | Efficacy of Soluble Dexamethasone in Refractory Sciatica NCT05000658 | Nantes University Hospital | Phase 3 |
| Completed | COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA NCT05626140 | Pakistan Institute of Medical Sciences | Phase 3 |
| Unknown | Effectiveness of Electro-acupuncture and Manual Therapy on Pain and Fucntion in Patients With Sciatica NCT04764890 | CEU San Pablo University | N/A |
| Completed | Effect of Muscle Energy Techniques on Functional Abilities in Patients With Discogenic Unilateral Sciatica NCT04918238 | Horus University | N/A |
| Unknown | Predictive Value of the Five-repetition Sit-to-stand Test After Lumbar Spine surgerySTS-3 Study. NCT04660656 | Bergman Clinics | — |
| Completed | Bilateral Sacroiliac Joint (SIJ) Injection in Lumbar Disc Prolapse NCT04326699 | Sohag University | N/A |
| Completed | Effects of Extension Biased External Limb Loading in Addition to McKenzie Extension Protocol in Lumbar Derange NCT04155450 | Foundation University Islamabad | N/A |
| Active Not Recruiting | Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisth NCT03879447 | Jaseng Medical Foundation | — |
| Recruiting | Transforaminal Epidural Injection in Acute Sciatica NCT03924791 | C.L.A.Vleggeert-Lankamp | N/A |
| Completed | The Effect of Accelerometer Guided App Feedback on Change in Activity in Patients With Low Back NCT04695912 | Rigshospitalet, Denmark | N/A |
| Recruiting | Comparing the Efficacy of Steroid, Acupuncture and Platelet Rich Plasma Injection in Patients With Sciatica NCT03801512 | Taipei Medical University Hospital | N/A |
| Unknown | RELATIONSHIP OF LUMBOPELVIC MUSCULATURE WITH FUNCTIONAL TESTS IN NON-PROFESSIONAL ATHLETES WITH LUMBAR DISC HE NCT03880370 | Universidad Complutense de Madrid | — |
| Completed | BOL-DP-o-04 in Patients With Low Back Pain and Sciatica NCT04145310 | Breath of Life International Pharma Ltd | Phase 1 / Phase 2 |
| Unknown | A Registry Study of Shujinjianyao Pill Used in Clinical Real World NCT03598153 | China Academy of Chinese Medical Sciences | — |
| Completed | The Effectiveness of Doin (Conduction Exercise) of the Pelvic Joint for HLD With Radiating Leg Pain NCT03571503 | Jaseng Medical Foundation | — |
| Completed | Observational Study on Effectiveness and Safety of Integrative Korean Medicine Treatment for Inpatients With S NCT03750591 | Jaseng Medical Foundation | — |
| Completed | Long-Term Course of Korean Medicine Treatment for Lumbar Disc Herniation NCT03426215 | Jaseng Medical Foundation | — |
| Unknown | Ultrasound-guided Lumbar Periradicular Injection: a Non Irradiating Infiltration Technique NCT03453775 | Université Libre de Bruxelles | N/A |
| Suspended | Aromatherapy Randomization of Pain Management in Adults NCT03377088 | Stony Brook University | N/A |
| Completed | NSAIDs in Sciatica NSAIDS IN SCIATICA NCT03347929 | Ostfold Hospital Trust | Phase 4 |
| Terminated | Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy NCT02951377 | University of Alberta | Phase 1 |
| Withdrawn | Intradiscal Discogel® in Resistant Sciatica NCT02313350 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Virtual Environment Rehabilitation for Patients With Motor Neglect Trial NCT03887962 | Cambridge University Hospitals NHS Foundation Trust | N/A |
| Completed | Trial of Pulsed Radiofrequency for Sciatica and Disc Herniation NCT04209322 | University of Roma La Sapienza | N/A |
| Withdrawn | Ultrasound-guided Caudal or Interlaminar Corticosteroid Epidural Injection for Sciatica NCT02897336 | University Hospital, Caen | N/A |
| Unknown | Efficacy of Acupuncture for Discogenic Sciatica NCT02770963 | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | N/A |
| Unknown | Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Depar NCT02777320 | Pamukkale University | Phase 4 |
| Completed | [18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica NCT02753101 | Stanford University | EARLY_Phase 1 |
| Completed | Physiotherapy for Sciatica; Is Earlier Better? NCT02618278 | Michael Reddington | Phase 3 |
| Completed | Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) NCT02644421 | Brigham and Women's Hospital | Phase 1 |
| Completed | Effects of Shinbaro Pharmacopuncture in Sciatic Pain Patients With Lumbar Disc Herniation NCT02384928 | Jaseng Medical Foundation | N/A |
| Unknown | "The Lived Experience of Investigations for Sciatica" NCT02512081 | University of Southampton | — |
| Completed | The Effectiveness of Neurodynamic Techniques in Patients With Nerve-Related Leg Pain NCT01954199 | Federal University of Health Science of Porto Alegre | N/A |
| Completed | Management Strategies for Patients With Low Back Pain and Sciatica NCT02391350 | University of Utah | N/A |
| Unknown | IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia NCT02504996 | Akdeniz University | Phase 4 |
| Completed | NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators NCT02284542 | St. Luke's Hospital, Pennsylvania | — |
| Completed | PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients NCT02130271 | Massachusetts General Hospital | — |
| Completed | Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg NCT01934868 | Hadassah Medical Organization | Phase 4 |
| Completed | A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radic NCT01917825 | Medtronic Spinal and Biologics | Phase 2 |
| Completed | BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy NCT01873404 | Biogen | Phase 2 |
| Completed | Effects of Control Scan for Presumed Difficult Epidural Infiltrations (ECHORACHIS) NCT01832844 | Nantes University Hospital | N/A |
| Completed | Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica NCT01816334 | University Hospital, Grenoble | Phase 4 |
| Unknown | Pain Relief by Platelet-rich Plasma (PRP) Treatment NCT01749839 | Saint Bernard Mission University | — |
| Completed | Steroids Versus Gabapentin NCT01495923 | Johns Hopkins University | N/A |
| Completed | Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciati NCT01405833 | Biogen | Phase 1 |
| Completed | Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidura NCT01240876 | Cephalon | Phase 1 / Phase 2 |
| Completed | Outcome of Surgery for Sciatica - a Comparison of Data From Three National Quality Registries NCT02889484 | Karolinska Institutet | — |
| Completed | Neural Dynamics Technique for the Treatment of Chronic Radicular Low Back Pain NCT01145105 | Clalit Health Services | N/A |
| Completed | A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With NCT00991172 | Regeneron Pharmaceuticals | Phase 2 |
| Completed | Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Partic NCT00961766 | Biogen | Phase 1 |
| Completed | The Value of Traction in Treatment of Lumbar Radiculopathy NCT00942227 | Intermountain Health Care, Inc. | Phase 3 |
| Completed | Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica NCT00668434 | Kaiser Permanente | Phase 2 |
| Completed | Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease NCT00749996 | Medtronic Spinal and Biologics | Phase 4 |
| Completed | A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release NCT00364546 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 3 |
| Completed | Efficacy of Epidural Etanercept in the Treatment of Sciatica NCT00364572 | Johns Hopkins University | Phase 1 / Phase 2 |
| Terminated | Chiropractic Prone Distraction for Lower Back Pain NCT00269503 | Samueli Institute for Information Biology | N/A |
| Completed | Alternative and Integrative Therapy for Lumbar Disk Herniation NCT01989403 | Jaseng Hospital of Korean Medicine | — |
| Unknown | Energy Specific Far Infrared Radiation Treatment for Sciatica NCT00573807 | GAAD Medical Research Institute Inc. | Phase 1 |
| Recruiting | Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Repla NCT06989632 | University of Valencia | — |
| Completed | Adalimumab in Severe and Acute Sciatica NCT00470509 | University Hospital, Geneva | Phase 2 |
| Unknown | Neuraxial Pethidine After Lumbar Surgery Trial NCT00163553 | Austin Health | Phase 3 |
| Unknown | Study of REN-1654 in Patients With Sciatica Pain NCT00107055 | Renovis | Phase 2 |
| Completed | Magnets in the Treatment of Sciatica NCT00044109 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Completed | The Efficacy of Oral Steroids in the Treatment of Acute Sciatica NCT00317447 | Kaiser Permanente | Phase 3 |
| Completed | The Efficacy of Active Conservative Treatment for Patients With Severe Sciatica. A Randomized Clinical Control NCT00246948 | The Back Research Center, Denmark | N/A |
| Completed | Topiramate in the Treatment of Sciatica NCT00011804 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Completed | Pain Treatment for Sciatica NCT00009672 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Completed | Manipulation or Microdiscectomy For Sciatica? A Prospective Randomized Controlled Trial. NCT00415220 | McMorland, Gordon, D.C. | Phase 2 |
| Completed | Effect of Antidepressants on Back Pain NCT00018200 | US Department of Veterans Affairs | Phase 2 |