NCT02130271

PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 42 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to see if the spine shows areas of inflammation using a specific type of imaging (pictures).

Detailed description

The purpose of this study is to determine if inflammation around the spinal nerves can be identified using a radioactive tracer \[11C\] PBR28 and integrated PET/MRI scan for the purpose of better treating patients who have radicular lumbar pain with epidural steroid injections.

Conditions

• Sciatica

Interventions

Type	Name	Description
DRUG	Radioactive dye	The radioactive dye \[11C\]PBR28 will be administered through an intravenous line (IV).
RADIATION	PET/MRI	All subjects will undergo a simultaneous PET/MRI scan. The scan will be up to 2 hours long.
OTHER	Blood draw	Up to 11 tablespoons of blood will be drawn through an intravenous line (IV-line) for two purposes: 1) testing for the subject's genetic affinity to the radioactive dye, and 2) testing for the presence inflammatory biomarkers.

Timeline

• Start date: 2014-04-01
• Primary completion: 2016-12-01
• Completion: 2018-12-01
• First posted: 2014-05-05
• Last updated: 2019-09-16

Locations

1 site across 1 country: United States