NCT07494136

Dose Dependent Steroid Injections

Dose Dependent Response to Interlaminar Steroid Injections for Lumbar Radiculopathy

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and function in lumbar radiculopathy at varying doses, and to evaluate difference in efficacy between triamcinolone and dexamethasone interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, with the overarching hypotheses that there is no difference in reported pain reduction, quality of life, or function among patients receiving low, moderate, or high doses, and no difference in reported pain reduction between triamcinolone and dexamethasone.

Conditions

• Lumbar Radiculopathy
• Sciatica
• Back Pain With Radiation

Interventions

Type	Name	Description
DRUG	Triamcinolone 10 Mg/mL Injectable Suspension	A single 10 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
DRUG	Triamcinolone 40 Mg/mL Injectable Suspension	A single 40 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
DRUG	Triamcinolone 80 Mg/mL Injectable Suspension	A single 80 mg Triamcinolone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
DRUG	Dexamethasone 2 MG	A single 2 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
DRUG	Dexamethasone 4mg	A single 4 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.
DRUG	Dexamethasone 8 MG	A single 8 mg Dexamethasone interlaminar lumbar epidural steroid injection administered in the lumbar spine.

Timeline

• Start date: 2026-05-01
• Primary completion: 2027-05-01
• Completion: 2027-05-01
• First posted: 2026-03-27
• Last updated: 2026-03-27

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study