| Not Yet Recruiting | The RESPLASH Study NCT06880562 | Tulane University | N/A |
| Recruiting | Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure NCT07383220 | Mohamed Mohamed Ali Morgan | N/A |
| Not Yet Recruiting | Perirenal Adipose Tissue Modification Therapy for Resistant Hypertension NCT07232966 | Yan Li | Phase 3 |
| Recruiting | Symplicity China Study NCT07081243 | Medtronic Vascular | — |
| Completed | Study of the Prevalence of Endogenous Hypercortisolism in Patients With Resistant Hypertension (MOMENTUM) NCT06829537 | Corcept Therapeutics | — |
| Not Yet Recruiting | Self-Management of Blood Pressure in Resistant Hypertension NCT06819241 | Taichung Veterans General Hospital | N/A |
| Not Yet Recruiting | SMART Study in Real World NCT06780696 | SyMap Medical (Suzhou), Ltd. | — |
| Not Yet Recruiting | Effectiveness and Safety of BiSAAE for Resistant Hypertension. NCT06282107 | First Affiliated Hospital of Chengdu Medical College | N/A |
| Recruiting | Arterial Stiffness as a Tool to Investigate Adherence in Resistant Hypertension NCT07207226 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Recruiting | Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With NCT06526858 | DeepQure Inc. | N/A |
| Recruiting | Allopurinol Improves Heart Function in African Americans With Resistant Hypertension NCT05888233 | VA Office of Research and Development | Phase 2 |
| Recruiting | Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus") Syndrome? NCT06450327 | University of Campinas, Brazil | — |
| Recruiting | Evaluation of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hyperten NCT06515795 | Universidade do Porto | N/A |
| Active Not Recruiting | A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on NCT06344104 | AstraZeneca | Phase 3 |
| Active Not Recruiting | Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension NCT05925569 | Brigham and Women's Hospital | N/A |
| Completed | A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hy NCT06168409 | AstraZeneca | Phase 3 |
| Unknown | JX09 SAD/MAD in Healthy Participants NCT06183671 | Ji Xing Pharmaceuticals Australia Pty Ltd | Phase 1 |
| Not Yet Recruiting | Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale NCT05994729 | Aurelia Hospital | N/A |
| Recruiting | A First-in-human Study of HyperQureTM", Laparoscopic Renal Denervation Therapy in Patient With Resistant Hyper NCT06216808 | DeepQure Inc. | N/A |
| Completed | A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on NCT06034743 | AstraZeneca | Phase 3 |
| Recruiting | Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patie NCT06169241 | National Institute of Cardiology, Laranjeiras, Brazil | EARLY_Phase 1 |
| Recruiting | Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization NCT06228677 | First Affiliated Hospital of Chengdu Medical College | — |
| Completed | An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients. NCT05562934 | Novartis Pharmaceuticals | Phase 2 |
| Active Not Recruiting | Aerobic Exercise and Resistant Hypertension NCT05563077 | Universidad Europea de Madrid | N/A |
| Unknown | Remote Ischemic Conditioning for the Treatment of Resistant Hypertension NCT05426707 | Ji Xunming,MD,PhD | N/A |
| Unknown | Superselective Adrenal Arterial Embolization for Resistant Hypertension NCT05552300 | First Affiliated Hospital of Chengdu Medical College | N/A |
| Unknown | Effects and Safety of Sacubitril/Valsartan on Refractory Hypertension NCT05545059 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Phase 3 |
| Completed | Safety And Tolerability Of Subcutaneous MANP In Difficult To Control/Resistant Hypertensive Subjects NCT05247528 | E-Star BioTech, LLC | Phase 1 |
| Completed | Evaluation of Systemic Microvascular Reactivity in Patients With Resistant Hypertension NCT05464849 | National Institute of Cardiology, Laranjeiras, Brazil | — |
| Recruiting | Endothelin-1 Receptor Blockade in Resistant Hypertension NCT04388124 | University Hospital, Rouen | Phase 2 |
| Completed | Treatment of Resistant Hypertension: Cohort Study NCT05087940 | Galenika AD Beograd | — |
| Completed | Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension NCT04331691 | Yonsei University | Phase 4 |
| Completed | Sacubitril/Valsartan in Resistant Hypertension NCT04637152 | Hospital Geral Roberto Santos | Phase 2 |
| Completed | A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN) NCT04519658 | CinCor Pharma, Inc. | Phase 2 |
| Unknown | Neuroinflammation in Hypertension Study NCT04478500 | Royal Perth Hospital | Phase 3 |
| Unknown | Evaluation of Intestinal Microbiota Manipulation to Treat Resistant Hypertension NCT04398693 | Hospital de Base | N/A |
| Unknown | Unilateral Laparoscopic Adrenalectomy for Resistant Hypertension in Patients With Adrenal Diseases NCT03535532 | Chinese Academy of Medical Sciences, Fuwai Hospital | N/A |
| Unknown | Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension（RSDARH） NCT03758196 | Henan Institute of Cardiovascular Epidemiology | N/A |
| Completed | A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High NCT03541174 | Idorsia Pharmaceuticals Ltd. | Phase 3 |
| Unknown | Development of Diagnostic and Treatment Strategy for Resistant Hypertension NCT03540992 | Yonsei University | — |
| Terminated | Therapeutic Effect of Sodium Intake Reduction in Treatment Resistant Hypertension NCT03424317 | DongGuk University | N/A |
| Active Not Recruiting | CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™ NCT03179800 | Vascular Dynamics, Inc. | N/A |
| Completed | Adrenal Artery Ablation for Primary Aldosteronism With Resistant Hypertension NCT04345198 | Third Military Medical University | N/A |
| Completed | The Role of Exercise Training in the Treatment of Resistant Hypertension NCT03090529 | Aveiro University | N/A |
| Completed | Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease NCT03071263 | Relypsa, Inc. | Phase 2 |
| Withdrawn | Subcutaneous Median Nerve Neuromodulation For Drug-Treatment Resistant Hypertension. NCT02926495 | Valencia Technologies Corporation | N/A |
| Completed | The Effect of BATon BP and Sympathetic Function in Resistant Hypertension (The Nordic BAT Study) NCT02572024 | Helsinki University Central Hospital | N/A |
| Unknown | Effects of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects NCT02670681 | Federal University of Paraíba | N/A |
| Unknown | Screening of Obstructive Sleep Apnea Syndrome in Patients With Resistant Systemic Arterial Hypertension: Pilot NCT03257488 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Terminated | Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registr NCT02295683 | Terumo Europe N.V. | — |
| Completed | Carotid Ultrasound Study NCT02001350 | Noblewell | — |
| Withdrawn | Rapid Renal Sympathetic Denervation for Resistant Hypertension II NCT01939392 | Medtronic Endovascular | Phase 2 / Phase 3 |
| Terminated | Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Ather NCT01918111 | Yonsei University | Phase 4 |
| Terminated | Renal Denervation by Allegro System in Patients With Resistant Hypertension NCT01874470 | Shanghai AngioCare Medical | Phase 3 |
| Completed | TrAnsCatHeter Intravascular Ultrasound Energy deliVery for rEnal Denervation (ACHIEVE) NCT01789918 | ReCor Medical, Inc. | N/A |
| Unknown | Renal Sympathetic Denervation and Insulin Sensitivity (RENSYMPIS Study) NCT01785732 | The Hospital District of Satakunta | N/A |
| Completed | REnAL denervatIon by ultraSound Transcatheter Emission NCT01529372 | ReCor Medical, Inc. | N/A |
| Completed | Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea S NCT01508754 | Universidade Federal do Rio de Janeiro | Phase 4 |
| Unknown | Study of Catheter Based Renal Denervation Therapy in Hypertension NCT01522430 | Erasme University Hospital | Phase 3 |
| Unknown | Prospective Study on Primary Aldosteronism in Resistant Hypertension NCT04213963 | University of Turin, Italy | — |
| Completed | Resistant Arterial Hypertension Cohort Study NCT01083017 | University Hospital, Geneva | — |
| Unknown | Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure NCT01044355 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Completed | Resistant Hypertension in Patients With Type-II-Diabetes Mellitus NCT01056367 | Svendborg Hospital | — |
| Completed | Renal Response to Lower Body Negative Pressure in Pre-hypertensive States NCT01734096 | PD Dr. Grégoire Wuerzner | Phase 4 |
| Completed | Effect of Continuous Positive Airway Pressure for Treatment of Obstructive Sleep Apnea on Resistant Hypertensi NCT00881985 | The University of Hong Kong | N/A |
| Completed | A Cross-sectional Study of the Occurrence and Effect of Obstructive Sleep Apnea in Subjects With Resistant Hyp NCT00843583 | The University of Hong Kong | — |
| Completed | Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment NCT01897727 | University of Alabama at Birmingham | N/A |
| Terminated | A Study Of Different Doses Of TBC3711 In Patients With Uncontrolled High Blood Pressure Already Taking Medicat NCT00272961 | Pfizer | Phase 2 |