NCT06169241

Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients

Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: National Institute of Cardiology, Laranjeiras, Brazil · Other Government
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.

Conditions

• Arterial Hypertension
• Resistant Hypertension
• Microvascular Function
• Nitrate Supplementation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Beetroot extract	Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.
DIETARY_SUPPLEMENT	Placebo	The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.

Timeline

• Start date: 2023-11-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2023-12-13
• Last updated: 2026-04-13

Locations

1 site across 1 country: Brazil