NCT01083017

Resistant Arterial Hypertension Cohort Study

Interventional Prospective Cohort Study, Multi-center With Nested Case-control Studies (Family-based and Non-family Based) on Individuals With Resistant Arterial Hypertension.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 74 (actual)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the epidemiology of resistant hypertension, evaluate the efficacy and feasibility of a standardized drug treatment regimen (including the randomization of two doses of the diuretic used - chlorthalidone), study two interventions in the group of patients that is non-compliant, and study environmental and genetic variables of individuals with resistant hypertension in a family design.

Conditions

• Hypertension
• Essential Hypertension
• Resistant Hypertension

Interventions

Type	Name	Description
DRUG	chlorthalidone	chlorthalidone 25mg/d vs. chlorthalidone 50mg/d
BEHAVIORAL	motivational intervention for non-compliant individuals	motivational interview(s) vs. repeated calls vs. no particular intervention
DRUG	standardized anti-hypertensive treatment	olmesartan, amlodipine, chlorthalidone, +- spironolactone

Timeline

• Start date: 2011-04-01
• Primary completion: 2017-05-01
• Completion: 2017-05-01
• First posted: 2010-03-09
• Last updated: 2018-10-30

Locations

3 sites across 1 country: Switzerland