| Completed | A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Comb Drug Drug Interaction | Phase 1 | 2025-01-18 |
| Recruiting | Registry to Collect Information on Pregnancy, Neonatal, and Infant Outcomes in Pregnant Women Exposed to QUVIV Insomnia | — | 2024-11-21 |
| Active Not Recruiting | Database Study to Provide Information on Pregnancy and Infant Outcomes Among Women Exposed to QUVIVIQ (Daridor Insomnia Disorder | — | 2023-11-30 |
| Completed | A Phase 1 Trial to Investigate the Biological Equivalence of 5 × 10 mg Tablets and 2 × 25 mg Tablets of Darido Healthy | Phase 1 | 2023-06-23 |
| Completed | A Study to Find Out if Daridorexant is Safe and Efficacious in Patients With Insomnia and Comorbid Nocturia Insomnia Disorder, Nocturia | Phase 4 | 2023-02-16 |
| Completed | A Study to Measure Daridorexant in Breast Milk of Healthy Lactating Women Healthy | Phase 1 | 2023-01-16 |
| Completed | A Study of the Effect of Daridorexant on Nighttime Body Posture, the Noise Level Required to Wake up, and the Healthy | Phase 1 | 2023-01-05 |
| Completed | A Study to Investigate the Effect of Itraconazole on the Way the Body Absorbs, Distributes, and Gets Rid of AC Healthy | Phase 1 | 2022-10-01 |
| Completed | Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to Insomnia | Phase 2 | 2022-09-06 |
| Completed | A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Dabiga Healthy | Phase 1 | 2022-09-03 |
| Completed | A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Midazo Healthy | Phase 1 | 2022-08-23 |
| Completed | A Study to Investigate the Effects of Daridorexant on Nighttime Breathing in Patients With Shallow or Paused B Obstructive Sleep Apnea of Adult | Phase 1 | 2022-08-17 |
| Completed | A Study to Investigate the Effect of Single and Repeated Oral Doses of ACT-539313 on What the Body Does to Flu Healthy | Phase 1 | 2022-02-18 |
| Completed | Bioequivalence Study of Different Aprocitentan Tablet Formulations Healthy Subjects | Phase 1 | 2022-02-02 |
| Completed | Pharmacokinetics of Omeprazole and Midazolam When Co-administered With ACT-1014-6470 Drug Drug Interaction, Healthy | Phase 1 | 2021-11-13 |
| Completed | A Study to Investigate the Pharmacokinetics of ACT-1014-6470 in Subjects With Severe Renal Impairment Compared Healthy | Phase 1 | 2021-06-16 |
| Completed | Multicenter Study to Evaluate the Efficacy and Safety of Oral ACT-539313 in the Treatment of Adults With Moder Binge-Eating Disorder | Phase 2 | 2021-02-16 |
| Completed | A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of A Healthy | Phase 1 | 2021-01-29 |
| Completed | A Placebo-controlled Phase 1 Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Single- an Healthy | Phase 1 | 2020-11-16 |
| Terminated | A Study in Healthy Subjects to Investigate the Safety and Tolerability of ACT- 541478 as Well as What ACT-5414 Healthy | Phase 1 | 2020-07-20 |
| Completed | Study in Healthy Subjects to Examine the Safety and Tolerability of ACT-1004-1239 Given as Multiple, Gradually Healthy | Phase 1 | 2020-07-11 |
| Completed | The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics Hepatic Impairment, Healthy Subjects | Phase 1 | 2020-06-26 |
| Completed | A Study in Healthy Male Subjects to Investigate the Effect of Famotidine and Efavirenz on the Way the Body Tak Healthy | Phase 1 | 2020-05-13 |
| Completed | A Study to Assess the Effect of Single Doses of Daridorexant on Electrocardiogram Parameters in Healthy Subjec Healthy | Phase 1 | 2020-02-28 |
| Completed | To Study the Effect of Aprocitentan on the Electrical Activity of the Heart in Healthy Men and Women Healthy Subjects | Phase 1 | 2020-01-14 |
| Withdrawn | A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressu Hypertension, Renal Insufficiency, Chronic | Phase 3 | 2020-01-01 |
| Completed | A Study to Compare a Single-dose of Two Different Formulations of ACT-709478 in Healthy Men Healthy Subjects | Phase 1 | 2019-12-16 |
| Completed | A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of A Healthy | Phase 1 | 2019-11-25 |
| Completed | Study of the Way the Body Takes up, Distributes, and Gets Rid of ACT-541468 in Subjects With Abnormal Kidney F Renal Insufficiency, Healthy | Phase 1 | 2019-09-24 |
| Completed | Natural History Study for Pediatric Patients With Early Onset of Either GM1 Gangliosidosis, GM2 Gangliosidoses GM1 Gangliosidosis, GM2 Gangliosidosis, Gaucher Disease, Type 2 | — | 2019-07-31 |
| Completed | A Study to Evaluate ID-085 in People With Mild, Moderate, and Severe Kidney Disease Renal Impairment | Phase 1 | 2019-04-29 |
| Completed | A Clinical Study to Examine the Drug-drug Interactions Between ACT-541468 and Citalopram in Healthy Male and F Healthy | Phase 1 | 2019-04-09 |
| Completed | A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses o Healthy | Phase 1 | 2019-03-25 |
| Completed | A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged Healthy | Phase 1 | 2019-03-25 |
| Completed | A Study to Investigate the Effects of ACT-541468 on Nighttime Respiratory Function in Patients With Mild to Mo Obstructive Sleep Apnea | Phase 1 | 2019-03-14 |
| Completed | A Clinical Study to Investigate the Food Effect on the Pharmacokinetics of ACT-541468 in Healthy Male Subjects Healthy | Phase 1 | 2019-03-09 |
| Completed | A Study in Healthy Subjects to Investigate Whether Administration of Lucerastat Can Affect Normal Heart Functi Healthy | Phase 1 | 2019-02-14 |
| Completed | Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrow Aneurysmal Subarachnoid Hemorrhage | Phase 3 | 2019-02-03 |
| Active Not Recruiting | A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease Fabry Disease | Phase 3 | 2018-12-18 |
| Completed | A Study to Evaluate the Effects of ACT-541468 on Respiration in Patients With Moderate Chronic Obstructive Pul Chronic Obstructive Pulmonary Disease | Phase 1 | 2018-11-15 |
| Completed | A Study to Evaluate the Effect of ACT-774312 in Subjects With Bilateral Nasal Polyposis Bilateral Nasal Polyposis | Phase 2 | 2018-10-19 |
| Completed | Study to Assess the Long Term Safety and Tolerability of ACT-541468 (Daridorexant) in Adult and Elderly Subjec Insomnia Disorder | Phase 3 | 2018-10-09 |
| Completed | A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart Funct Healthy Subjects | Phase 1 | 2018-09-18 |
| Completed | Study to Evaluate the Abuse Potential of ACT-541468 in Healthy Recreational Drug Users Healthy Recreational Drug Users | Phase 1 | 2018-09-07 |
| Completed | A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects Healthy | Phase 1 | 2018-08-28 |
| Completed | A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Cl Healthy Subjects | Phase 1 | 2018-07-19 |
| Completed | A Study to Evaluate How Aprocitentan is Safe and How it is Absorbed and Broken Down in the Body of Japanese an Healthy Subjects | Phase 1 | 2018-07-17 |
| Completed | Efficacy and Safety of Lucerastat Oral Monotherapy in Adult Subjects With Fabry Disease Fabry Disease | Phase 3 | 2018-06-21 |
| Completed | A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Resistant Hypertension | Phase 3 | 2018-06-18 |
| Completed | Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects With Insomn Insomnia Disorder | Phase 3 | 2018-06-04 |
| Completed | Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering F Insomnia Disorder | Phase 3 | 2018-05-29 |
| Completed | A Study to Evaluate the Pharmacokinetics of ACT-541468 in Subjects With Mild, Moderate, and Severe Hepatic Imp Hepatic Impairment | Phase 1 | 2018-02-26 |
| Completed | A Study to Evaluate if ID-085 is Safe, Its Fate in the Body as Well as Its Potential Effects on the Body in He Healthy Subjects | Phase 1 | 2018-01-12 |
| Completed | Effect of Cimetidine on the Pharmacokinetics of Lucerastat in Healthy Subjects Healthy Subjects | Phase 1 | 2018-01-09 |
| Completed | Pharmacokinetic Interaction Between Midazolam and ID-082 in Healthy Subjects Healthy | Phase 1 | 2017-11-27 |
| Completed | A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-541468 Can Affect the Fate in th Healthy Subjects | Phase 1 | 2017-10-30 |
| Completed | A Study to Evaluate the Effect of ACT-709478 in Photosensitive Epilepsy Patients Photosensitive Epilepsy | Phase 2 | 2017-10-06 |
| Completed | A Study in Healthy Male Subjects to Investigate Whether Administration of ACT-132577 Can Affect Rosuvastatin's Healthy Subjects | Phase 1 | 2017-08-10 |
| Completed | Study to Evaluate Safety and Tolerability of ACT-709478 in Healthy Subjects Healthy Subjects | Phase 1 | 2017-07-07 |
| Completed | A Study to Evaluate ACT-132577 in Healthy Subjects and in People With Severe Kidney Disease Severe Renal Impairment, Healthy Subjects | Phase 1 | 2017-06-03 |
| Completed | A Study to Evaluate ACT-132577 in Healthy Male Subjects Healthy Subjects | Phase 1 | 2017-03-28 |
| Completed | A Study of ACT-541468 in Healthy Japanese and Caucasian Subjects Healthy Subjects | Phase 1 | 2017-03-15 |
| Completed | Study to Validate the Questionnaire Called IDSIQ™ in Patients With Insomnia Disorder Insomnia Disorder | Phase 2 | 2017-02-15 |
| Completed | A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 Healthy Subjects | Phase 1 | 2017-01-01 |
| Completed | Efficacy and Safety of ACT-541468 in Elderly Subjects With Insomnia Disorder Insomnia Disorder | Phase 2 | 2016-11-28 |
| Completed | Efficacy and Safety of ACT-541468 in Adult Subjects With Insomnia Disorder Insomnia Disorder | Phase 2 | 2016-10-04 |
| Terminated | A Study to Evaluate if AC-084 is Safe, Its Fate in the Body as Well as Its Potential Effects on the Body in He Healthy Subjects | Phase 1 | 2016-09-12 |
| Completed | A Study to Investigate the Effect of ACT-132577 on the Pharmacokinetics of Midazolam and 1-hydroxy Midazolam i Healthy Subjects | Phase 1 | 2016-07-01 |
| Completed | Clinical Study to Assess Body Fluid Homeostasis After Administration of ACT-132577 in Healthy Subjects Healthy Subjects | Phase 1 | 2016-06-01 |
| Completed | Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With An Aneurysmal Subarachnoid Hemorrhage | Phase 2 | 2016-03-01 |
| Completed | First-in-man Study of Single Ascending Dose of a New Drug for Neurological Disorders Healthy Subjects | Phase 1 | 2016-02-19 |
| Completed | First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders Healthy Subjects | Phase 1 | 2016-02-01 |
| Completed | Dose-finding Study With ACT-132577 (Aprocitentan) in Participants With Essential Hypertension Essential Hypertension | Phase 2 | 2015-12-14 |
| Completed | A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of ACT-54146 Healthy Subjects | Phase 1 | 2015-10-01 |
| Completed | Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects Healthy Subjects | Phase 1 | 2015-09-01 |
| Completed | A Single Ascending Dose Study of ACT-541468 in Healthy Male Subjects Healthy Subjects | Phase 1 | 2015-02-01 |
| Completed | A Study to Assess the Safety and Tolerability of Lucerastat in Subjects With Fabry Disease Fabry Disease | Phase 1 | 2015-02-01 |
| Completed | Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Subjects Healthy Subjects | Phase 1 | 2014-06-01 |
| Completed | Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-389949 in Healthy Healthy Subjects | Phase 1 | 2012-11-01 |
| Completed | Efficacy, Safety, and Tolerability Study of ACT-129968 in Patients With Seasonal Allergic Rhinitis Seasonal Allergic Rhinitis | Phase 3 | 2011-12-01 |
| Completed | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-451840 in Healthy Subjects (Part A) Healthy | Phase 1 | 2011-12-01 |
| Completed | A Study to Assess the Tolerability, Safety, Pharmacodynamics, and Pharmacokinetics of Ascending Single Doses ( Healthy | Phase 1 | 2011-12-01 |
| Completed | Single-ascending Dose Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of Safety, Tolerability, Pharmacodynamics | Phase 1 | 2011-11-01 |
| Completed | Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-389949 Healthy Subjects | Phase 1 | 2011-11-01 |
| Completed | Single-ascending Oral Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynami Safety, Tolerability, Pharmacokinetics and Pharmacodynamics | Phase 1 | 2011-10-01 |
| Completed | Clinical Study to Assess the Pharmacokinetics, Safety, and Tolerability of ACT-129968 in Healthy Subjects Healthy Subjects | Phase 1 | 2011-07-01 |
| Completed | Essential Hypertension Essential Hypertension | Phase 2 | 2011-02-01 |
| Completed | Study of ACT-129968 in Adult Patients With Seasonal Allergic Rhinitis Seasonal Allergic Rhinitis | Phase 2 | 2010-11-01 |
| Completed | Clinical Study to Explore the Efficacy of ACT-129968 in Patients With Partly Controlled Asthma Asthma | Phase 2 | 2010-11-01 |
| Terminated | Tezosentan in Patients With Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 2 | 2010-09-01 |
| Terminated | Tezosentan in Pulmonary Arterial Hypertension Pulmonary Arterial Hypertension | Phase 2 | 2010-08-01 |
| Terminated | Clazosentan in Aneurysmal Subarachnoid Hemorrhage Aneurysmal Subarachnoid Hemorrhage | Phase 3 | 2009-07-01 |
| Completed | Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Aneurysmal Subarachnoid Hemorrhage | Phase 3 | 2007-12-14 |
| Terminated | Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to L Heart Diseases, Hypertension, Pulmonary | Phase 3 | 2007-04-01 |
| Completed | Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage Aneurysmal Subarachnoid Hemorrhage | Phase 2 | 2005-01-10 |
| Completed | A Study to Assess the Safety, Tolerability and Pharmacokinetics of Lucerastat (CDP923) After Multiple Dosing i Healthy Subjects | Phase 1 | 2003-12-01 |
| Completed | Tezosentan in the Treatment of Acute Heart Failure Acute Heart Failure, Acute Decompensation of Chronic Heart Failure, New Onset of Heart Failure | Phase 3 | 2003-04-01 |
| Completed | Tezosentan in Acute Heart Failure Acute Heart Failure, Acute Decompensation of Chronic Heart Failure, New Onset of Heart Failure | Phase 3 | 2003-04-01 |
| Completed | A Study to Assess the Safety and Pharmacokinetics of Lucerastat (OGT 923) in Healthy Subjects Healthy Subjects | Phase 1 | 2002-10-01 |