NCT01734096

Renal Response to Lower Body Negative Pressure in Pre-hypertensive States

Effect of Lower Body Negative Pressure and Angiotensin II Receptor Blockade on Renal Hemodynamic, Neuro-hormonal and Tubular Response in Pre-hypertensive States: a Randomized Controlled Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: PD Dr. Grégoire Wuerzner · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.

Conditions

• Hypertension
• Obesity
• White Coat Hypertension
• Resistant Hypertension

Interventions

Type	Name	Description
OTHER	Lower body negative pressure (LBNP)	Lower limbs are put in in LBNP device for one hour (-30 mbar)
DRUG	Candesartan cilexetil	candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group

Timeline

• Start date: 2009-05-01
• Primary completion: 2013-04-01
• Completion: 2016-04-01
• First posted: 2012-11-27
• Last updated: 2017-05-24

Locations

2 sites across 1 country: Switzerland