NCT04345198

Adrenal Artery Ablation for Primary Aldosteronism With Resistant Hypertension

Adrenal Artery Ablation Treats Primary Aldosteronism With Resistant Hypertension (AAA-RHT)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Third Military Medical University · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Primary aldosteronism(PA) is the most common endocrine cause of resistant hypertension. Surgery and medicine are the main treatment for PA by the current guidelines. However,only a small part of patients with PA meet the surgical criteria, and most of them have to take spironolactone or other antihypertensive drugs for long time. On the other side, long-term inhibition of aldosterone receptor may cause hyperkalemia, male breast hyperplasia and other adverse reactions. Moreover, hyperaldosterone is still not corrected by spironolactone, which cause extensive cerebrovascular damages even though blood pressure and blood potassium had been normalized. With the development of adrenal vein sampling and adrenal ablation, the precise diagnosis and treatment of PA is possible. Selective adrenal artery ablation (AAA) was observed with significant decrease of blood aldosterone and blood pressure in patients with PA, which made it promissing that primary aldosteronism with resistant hypertension could be relieved by adrenal artery ablation.

Conditions

• Resistant Hypertension

Interventions

Type	Name	Description
PROCEDURE	Adrenal Artery Ablation	Intervention with adrenal artery ablation is performed in PA patients with resistant hypertension.

Timeline

• Start date: 2017-10-01
• Primary completion: 2019-04-15
• Completion: 2019-10-15
• First posted: 2020-04-14
• Last updated: 2020-04-14

Locations

1 site across 1 country: China