| Not Yet Recruiting | A Study of CSTI-500 in Patients With Prader-Willi Syndrome NCT07348601 | ConSynance Therapeutics | Phase 2 |
| Not Yet Recruiting | A 2-Part Study to Assess Efficacy, Safety and Tolerability of BMB-101 for the Treatment of Patients With Prade NCT07266324 | Bright Minds Biosciences Pty Ltd | Phase 2 |
| Enrolling By Invitation | Observational Study of VYKAT™ XR in Patients With Prader-Willi Syndrome NCT07450664 | Soleno Therapeutics, Inc. | — |
| Enrolling By Invitation | A Study of Pitolisant in Participants With Prader-Willi Syndrome NCT07219485 | Harmony Biosciences Management, Inc. | Phase 3 |
| Not Yet Recruiting | Brain Olfactory Pathways in Prader-Willi Syndrome NCT07006207 | University Hospital, Toulouse | N/A |
| Recruiting | Tirzepatide in PWS, HO and GNSO NCT06901245 | Grace Kim | Phase 4 |
| Recruiting | Autistic Symptomatology and Sensory Profile in Children With Prader-Willi Syndrome NCT06877715 | University Hospital, Toulouse | — |
| Active Not Recruiting | A Study of Setmelanotide in Patients With Prader-Willi Syndrome NCT06772597 | Rhythm Pharmaceuticals, Inc. | Phase 2 |
| Completed | Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact NCT06900335 | Corporacion Parc Tauli | — |
| Recruiting | Physical Activity and Community EmPOWERment Project NCT06740162 | University of North Carolina, Chapel Hill | N/A |
| Suspended | ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial NCT06828861 | Aardvark Therapeutics, Inc. | Phase 3 |
| Suspended | The Hunger Elimination or Reduction Objective (HERO ) Open -Label Extension (OLE) Trial NCT07197034 | Aardvark Therapeutics, Inc. | Phase 3 |
| Recruiting | Institutional Registry of Rare Diseases NCT06573723 | Hospital Italiano de Buenos Aires | — |
| Recruiting | A Study of Pitolisant in Patients With Prader-Willi Syndrome NCT06366464 | Harmony Biosciences Management, Inc. | Phase 3 |
| Recruiting | A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment NCT06239116 | Rhythm Pharmaceuticals, Inc. | Phase 1 / Phase 2 |
| Unknown | Adolescent Projections During Transition in Prader-Willi Syndrome NCT06279052 | University Hospital, Toulouse | N/A |
| Completed | Respiratory Restriction in Prader-Willi Syndrome NCT06851351 | Istituto Auxologico Italiano | — |
| Active Not Recruiting | A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS NCT06144645 | Foundation for Prader-Willi Research | Phase 3 |
| Recruiting | Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Wi NCT06720571 | University of Bordeaux | N/A |
| Recruiting | Impact of Bright Light Therapy on Prader-Willi Syndrome NCT05939453 | Maimonides Medical Center | N/A |
| Withdrawn | An Open-Label Study of Oral NNZ-2591 in Prader-Willi Syndrome (PWS-001) NCT05879614 | Neuren Pharmaceuticals Limited | Phase 2 |
| Recruiting | Cerebellar TMS and Satiety in Prader-Willi Syndrome NCT05938543 | Brigham and Women's Hospital | N/A |
| Withdrawn | Mitochondrial Complex I Dysfunction in PWS NCT03831425 | The Hospital for Sick Children | Phase 2 |
| Completed | Evaluation of the Psychological Profile of Adult Patients With Prader-Willi Syndrome NCT06295315 | Istituto Auxologico Italiano | — |
| Completed | Development of a Newborn Screening Assay for Angelman Syndrome and Prader-Willi Syndrome NCT05783791 | University of Wisconsin, Madison | — |
| Recruiting | The Intervention of Obesity in Children With Prader-Willi Syndrome Using Prebiotics and Probiotics NCT05791604 | Children's Hospital of Fudan University | N/A |
| Not Yet Recruiting | Growth Hormone Study in Adults With Prader-Willi Syndrome NCT04484051 | Erasmus Medical Center | — |
| Active Not Recruiting | Open-Label Extension Study of DCCR in Patients With Prader-Willi Syndrome NCT05701774 | Soleno Therapeutics, Inc. | Phase 3 |
| Completed | Understanding the Role of Gut Microbiota in Hyperphagia in Prader-Willi Syndrome NCT05541003 | Rutgers, The State University of New Jersey | Phase 2 |
| Withdrawn | A Phase 3 Extension Study of RAD011 (Cannabidiol Oral Solution) in Patients With Prader-Willi Syndrome NCT05387798 | Radius Pharmaceuticals, Inc. | Phase 3 |
| Completed | A Pharmacokinetic and Safety Study of CSTI-500 in Subjects With Prader-Willi Syndrome NCT05504395 | ConSynance Therapeutics | Phase 1 |
| Completed | Ultrasound to Assess Sarcopenia in Prader Willi Syndrome NCT06448871 | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | — |
| Completed | Study to Evaluate Efficacy, Safety, and Tolerability of RGH-706 in Prader-Willi Syndrome NCT05322096 | Gedeon Richter Plc. | Phase 2 |
| Completed | A Study of Oral ARD-101 in Patients With Prader-Willi Syndrome NCT05153434 | Aardvark Therapeutics, Inc. | Phase 2 |
| Active Not Recruiting | Biological Age Assessment in Adults With Prader-Willi Syndrome (ETABIOLPWS) NCT05778032 | Istituto Auxologico Italiano | — |
| Completed | Characterization of Serum Proteome in Subjects With Prader Willi Syndrome (PROTEOMARKER) NCT05761184 | Istituto Auxologico Italiano | — |
| Terminated | A Study to Assess RAD011 (Cannabidiol Oral Solution) for the Treatment of Participants With Prader-Willi Syndr NCT05098509 | Radius Pharmaceuticals, Inc. | Phase 2 / Phase 3 |
| Completed | Effect of Intranasal Oxytocin on Dysphagia in Children and Adolescents With Prader-Willi Syndrome NCT05298085 | University Hospital, Toulouse | Phase 2 / Phase 3 |
| Withdrawn | Study of Tesomet With Open-label Extension in Subjects With Prader-Willi Syndrome NCT05198362 | Saniona | Phase 2 |
| Completed | Improving Care of Prader-Willi Syndrome : Evaluation of a New Care Program Combining Adapted Physical Activity NCT05249998 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Long-term Interventional Follow-up Study of Children With Prader-Willi Syndrome Included in the OTBB3 Clinical NCT05032326 | University Hospital, Toulouse | Phase 3 |
| Unknown | Ghrelin in Patients With a Rare Disease Associated With Intellectual Disability, and Hyperphagia, and/or Overw NCT04768803 | University Hospital, Toulouse | — |
| Completed | Study of the Efficacy and Safety of Somatropin in Japanese Participants With PWS NCT04697381 | Pfizer | Phase 3 |
| Completed | Probiotic Treatment for Prader-Willi Syndrome NCT04685057 | Fundació Sant Joan de Déu | N/A |
| Completed | Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader NCT05657860 | Maimonides Medical Center | Phase 4 |
| Active Not Recruiting | A Phase 2 Study to Evaluate the Safety and Efficacy of Pitolisant in Patients With Prader-Willi Syndrome, Foll NCT04257929 | Harmony Biosciences Management, Inc. | Phase 2 |
| Completed | CBDV vs Placebo in Children and Adults up to Age 30 With Prader-Willi Syndrome (PWS) NCT03848481 | Montefiore Medical Center | Phase 2 |
| Completed | Study of Emotion and Cognition Abilities of Children With PWS and Proposition of an Innovative Remediation NCT04526379 | University Hospital, Toulouse | N/A |
| Withdrawn | tVNS in Children With Prader-Willi Syndrome NCT04396470 | Stanford University | Phase 1 / Phase 2 |
| Completed | Assessment of CAI in Adults With PWS. NCT04700644 | Medical University of Warsaw | — |
| Completed | Oxytocin Treatment in Neonates and Infants With Prader-Willi Syndrome NCT04283578 | University Hospital, Toulouse | Phase 3 |
| Withdrawn | Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior NCT04066088 | NYU Langone Health | Phase 4 |
| Withdrawn | An Open-Label Study of DCCR Tablet in Patients With PWS NCT04086810 | Soleno Therapeutics, Inc. | Phase 3 |
| Completed | PWS Outcomes Assessment Study NCT04102839 | Soleno Therapeutics, Inc. | — |
| Completed | Fiber Intervention on Gut Microbiota in Children With Prader-Willi Syndrome NCT04150991 | University of Alberta | N/A |
| Unknown | Stress and Brain Response Using MEG in PWS NCT04032639 | The Hospital for Sick Children | — |
| Terminated | Home-based SSP on Individuals With PWS NCT03871751 | Indiana University | N/A |
| Terminated | Effects of Livoletide (AZP-531) on Food-related Behaviors in Patients With Prader-Willi Syndrome NCT03790865 | Millendo Therapeutics SAS | Phase 2 / Phase 3 |
| Enrolling By Invitation | Parent and Infant Inter(X)Action Intervention (PIXI) NCT03836300 | RTI International | N/A |
| Completed | Phase 3 Study of Intranasal Carbetocin (LV-101) in Patients With Prader-Willi Syndrome NCT03649477 | Levo Therapeutics, Inc. | Phase 3 |
| Enrolling By Invitation | Early Check: Expanded Screening in Newborns NCT03655223 | RTI International | — |
| Recruiting | GROWing Up With Rare GENEtic Syndromes NCT04463316 | dr. Laura C. G. de Graaff-Herder | — |
| Completed | Open-Label Extension Study of DCCR in PWS Followed by Double-Blind, Placebo-Controlled, Randomized Withdrawal NCT03714373 | Soleno Therapeutics, Inc. | Phase 3 |
| Completed | Natural History Study of Serious Medical Events in PWS NCT03718416 | Foundation for Prader-Willi Research | — |
| Terminated | A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Particip NCT03458416 | Radius Pharmaceuticals, Inc. | Phase 2 |
| Terminated | Cannabidiol Oral Solution for the Treatment of Patients With Prader-Willi Syndrome NCT02844933 | Radius Pharmaceuticals, Inc. | Phase 2 |
| Completed | A Study of Diazoxide Choline in Patients With Prader-Willi Syndrome NCT03440814 | Soleno Therapeutics, Inc. | Phase 3 |
| Unknown | A Study to Evaluate the Efficacy and Safety of Recombinant Human Growth Hormone Injection in Patients With Pra NCT03554031 | Changchun GeneScience Pharmaceutical Co., Ltd. | Phase 3 |
| Completed | Intranasal Oxytocin vs. Placebo for the Treatment of Hyperphagia in Prader-Willi Syndrome NCT03197662 | Eric Hollander | Phase 2 |
| Completed | A Study of GLWL-01 in Patients With Prader-Willi Syndrome NCT03274856 | GLWL Research Inc. | Phase 2 |
| Completed | Targeting the Gut Microbiome for Prader-Willi Syndrome Treatment NCT03548480 | Fundació Sant Joan de Déu | N/A |
| Terminated | Optimizing the Social Engagement System in Prader-Willi Syndrome: Insights From the Polyvagal Theory NCT03101826 | Indiana University | N/A |
| Completed | Intranasal Oxytocin for Infants With Prader-Willi Syndrome NCT03245762 | University of Florida | Phase 1 / Phase 2 |
| Unknown | A 5 Treatment Period Pharmacokinetic Study Evaluating Dose Proportionality and Food Effects of Diazoxide Choli NCT02893618 | Essentialis, Inc. | Phase 2 |
| Completed | GH in Adults With PWS, Effect on Hypotonia Evaluated by Functional MRI, Relationship With Strength and Body Co NCT03616509 | Corporacion Parc Tauli | Phase 4 |
| Unknown | Effects of Transcranial Direct Current Stimulation (tDCS) on Individuals With Prader-Willi Syndrome NCT03324906 | Federal University of São Paulo | N/A |
| Recruiting | IDMet (RaDiCo Cohort) (RaDiCo-IDMet) NCT05945576 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Completed | Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants. NCT03081832 | University Hospital, Toulouse | N/A |
| Completed | Oxytocin Intranasal Administrations in Children With Prader-Willi Syndrome Aged From 3 to 12 Years NCT03114371 | University Hospital, Toulouse | N/A |
| Completed | Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome NCT03031626 | The Hospital for Sick Children | Phase 4 |
| Unknown | Therapeutic Effects of Hippotherapy in Children With Prader-Willi Syndrome NCT03858023 | Samsung Medical Center | N/A |
| Unknown | Post Exercise Irisin Levels in PWS Patients NCT02728544 | Shaare Zedek Medical Center | N/A |
| Completed | Effects of Progressive Elastic Band Resistance Training NCT03565081 | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | N/A |
| Completed | Proof of Concept Study of Vagus Nerve Stimulation NCT03689621 | Jessica Beresford-Webb | N/A |
| Completed | Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome NCT02629991 | Montefiore Medical Center | Phase 2 |
| Completed | SNP-based Microdeletion and Aneuploidy RegisTry (SMART) NCT02381457 | Natera, Inc. | — |
| Completed | Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Will NCT02311673 | Rhythm Pharmaceuticals, Inc. | Phase 2 |
| Completed | Oxytocin Trial in Prader-Willi Syndrome NCT02013258 | University of Florida | Phase 1 |
| Unknown | Deep Brain Stimulation for the Treatment of Obesity in Patients With Prader-Willi Syndrome NCT02297022 | University of Sao Paulo General Hospital | Phase 1 |
| Active Not Recruiting | PREPL in Health and Disease NCT02263781 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Terminated | Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syn NCT02179151 | Zafgen, Inc. | Phase 3 |
| Completed | Growth Hormone in Children Under 2 Years With Prader-Willi in Hospital of Sabadell NCT02205450 | Corporacion Parc Tauli | — |
| Completed | Effects of Intranasal Administration of Oxytocin in Adults With Prader-Willi Syndrome NCT02804373 | University Hospital, Toulouse | Phase 2 / Phase 3 |
| Completed | Study to Assess the Efficacy and Safety of Eutropin in Prader-Willi Syndrome NCT02204163 | LG Life Sciences | Phase 3 |
| Completed | Prader-Willi Syndrome Macronutrient Study NCT02011360 | Duke University | N/A |
| Completed | Clinical Study of Diazoxide Choline Controlled-Release Tablet (DCCR) in Patients With Prader-Willi Syndrome NCT02034071 | Essentialis, Inc. | Phase 1 / Phase 2 |
| Completed | Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome NCT02368379 | Nationwide Children's Hospital | N/A |
| Completed | Hypoglycemia in Prader-Willi Syndrome NCT01897363 | University of Florida | — |
| Completed | An Efficacy, Safety, and Pharmacokinetics Study of Beloranib in Obese Subjects With Prader-Willi Syndrome NCT01818921 | Zafgen, Inc. | Phase 2 |
| Completed | Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Inf NCT02205034 | University Hospital, Toulouse | Phase 1 / Phase 2 |
| Completed | Pilot Study of Startle-response Test to Assess Transcranial Direct Current Stimulation-induced Modulation of H NCT01863017 | University of Kansas Medical Center | N/A |
| Completed | PWS European Blood Bank for Infants and Controls From 0 to 48 Months NCT02529085 | University Hospital, Toulouse | N/A |
| Terminated | Study of the Efficacy of Topiramate in Patients With Prader Willi Syndrome Over 8 Weeks NCT02810483 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Unknown | Aromatase Inhibitor in Bone Maturation, Children With Silver Russell or Prader-Willi Syndrome NCT01520467 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome NCT01444898 | Children's Hospital Los Angeles | N/A |
| Terminated | Liraglutide Use in Prader-Willi Syndrome NCT01542242 | Vancouver General Hospital | Phase 4 |
| Completed | Bioequivalence of Two Somatropin Products (Norditropin® Versus Genotropin®) in Healthy Adult Volunteers NCT01401244 | Novo Nordisk A/S | Phase 1 |
| Completed | Tolerance of Intranasal Administration of OT in Prader-Willi Newborn Babies NCT01548521 | University Hospital, Toulouse | Phase 1 / Phase 2 |
| Completed | Sleep Abnormalities in Rare Genetic Disorders: AS, RTT, and PW NCT02670694 | Baylor College of Medicine | — |
| Unknown | Family-based Intervention for Youth With Prader-Willi Syndrome: The Active Play at Home Study NCT02058342 | California State University, Fullerton | N/A |
| Completed | The Intestinal Function in People With Prader-Willi Syndrome NCT01523288 | Aarhus University Hospital | — |
| Completed | Comparative Study Between Prader-Willi Patients Who Take Oxytocin Versus Placebo NCT01038570 | University Hospital, Toulouse | Phase 2 |
| Recruiting | Register of Patients With Prader-Willi Syndrome NCT02829684 | University Hospital, Toulouse | — |
| Completed | Cortisol Activity in Patients With Prader-Willi Syndrome and Healthy Controls NCT00932932 | Children's Mercy Hospital Kansas City | — |
| Completed | Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome? NCT01298180 | University Hospital, Toulouse | Phase 4 |
| Unknown | Exploring Stress and Coping Behaviors of the Major Carer Whose Children With Prader-Willi Syndrome NCT00808548 | Taichung Veterans General Hospital | — |
| Completed | Retrospective Observational Study on Efficacy and Safety of Norditropin® in Children With Prader-Willi Syndrom NCT00705172 | Novo Nordisk A/S | — |
| Completed | Behavioral Treatment of Obsessive-Compulsive Symptoms in Youth With Prader-Willi Syndrome: A Pilot Project NCT00742664 | University of South Florida | Phase 1 / Phase 2 |
| Completed | Gut Derived Hormones, Body Composition and Metabolism in Prader-Willi Syndrome NCT00551343 | Garvan Institute of Medical Research | N/A |
| Terminated | Effect of Rimonabant on Weight Gain and Body Composition in Adults With Prader Willi Syndrome NCT00603109 | Weill Medical College of Cornell University | Phase 3 |
| Completed | Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome NCT01622751 | Samsung Medical Center | — |
| Completed | Plasma Adiponectin Level and Vascular Endothelial and Smooth Muscle Cell Function in Children With Prader-Will NCT01479322 | Samsung Medical Center | — |
| Terminated | Octreotide Therapy in Children and Young Adults With Prader-Willi Syndrome (PWS) NCT00399893 | Duke University | N/A |
| Completed | Characteristics of Prader-Willi Syndrome and Early-onset Morbid Obesity NCT00375089 | University of Florida | — |
| Completed | Correlation of Hyperghrelinemia With Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndr NCT00474643 | Samsung Medical Center | — |
| Completed | Nordic Study on the Effects of Growth Hormone (Norditropin SimpleXx) Treatment in Adults With Prader-Willi Syn NCT00372125 | Karolinska University Hospital | N/A |
| Completed | Growth Hormone Use in Adults With Prader-Willi Syndrome NCT00444964 | Children's Mercy Hospital Kansas City | Phase 3 |
| Completed | Characterization of Transcriptional Regulators of Ghrelin Hormone Which Causes Genetic Obesity NCT01404624 | Samsung Medical Center | — |
| Terminated | Prader-Willi Syndrome and Appetite NCT00175305 | University of British Columbia | Phase 3 |
| Completed | Macronutrient Regulation of Ghrelin and Peptide YY NCT02464514 | Duke University | N/A |
| Completed | Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome NCT00065923 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | N/A |
| Completed | Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes NCT00004351 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Completed | Increased Expression of Adiponectin Receptor 2 in the Mononuclear Cells in Children With Prader-Willi Syndrome NCT00800852 | Samsung Medical Center | — |