NCT07006207

Brain Olfactory Pathways in Prader-Willi Syndrome

Deciphering Brain Olfactory Pathways in Prader-Willi Syndrome

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 5 Years – 7 Years
• Healthy volunteers: Not accepted

Summary

Studying the cerebral activity of children with Prader-Willi Syndrom (PWS) when the study propose to them nasal activations.

Detailed description

The present study propose to implement fMRI and olfactory tests to describe olfactory brain activation and olfactory skills in early OT-exposed and non-exposed children with PWS. This study is part of a wider project in collaboration with the team of S. Steculorum at the Max Planck Institute in Germany who assess the architectural and molecular characterization of the olfactory system development in a mice model of PWS and the role of early OT treatment. Moreover, the study will take advantage of the MRI to document the long-term brain connectivity of early OT-exposed and non-exposed children.

Conditions

• Prader-Willi Syndrome

Interventions

Type	Name	Description
OTHER	olfactory stimulation	the patients have a sniff-test
OTHER	functional MRI	patients have a an f MRI

Timeline

• Start date: 2025-06-23
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2025-06-05
• Last updated: 2025-06-05

Locations

1 site across 1 country: France