| Completed | Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grad NCT07184268 | Cairo University | N/A |
| Recruiting | The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness NCT07053969 | The University of Texas Health Science Center at San Antonio | N/A |
| Recruiting | Full Mouth Ultrasonic Debridement Carried Out With Either Piezoelectric or Magnetostrictive Device NCT06934291 | University of Siena | N/A |
| Recruiting | A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of Furcations NCT06684769 | Riga Stradins University | N/A |
| Recruiting | Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy NCT07443410 | University Hospital Heidelberg | N/A |
| Completed | Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingi NCT07243145 | Selcen Ozcan Bulut | — |
| Not Yet Recruiting | Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease NCT06528522 | Necmettin Erbakan University | — |
| Completed | Evaluation of Coconut Oil Mouth Rinse on Periodontal Parameters NCT07175090 | University of Pristina | EARLY_Phase 1 |
| Completed | Evaluation of Chlorhexidine Gel Associated with Photodynamic Therapy in the Treatment of Chronic Periodontitis NCT06469294 | Universidade Federal Fluminense | N/A |
| Not Yet Recruiting | Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs NCT06351722 | Necmettin Erbakan University | — |
| Completed | Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III NCT06426550 | Universidade Federal Fluminense | N/A |
| Recruiting | 3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV NCT07293962 | Mahsa University | Phase 2 |
| Recruiting | Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement NCT06149585 | Case Western Reserve University | — |
| Completed | Fetuin A Association in Periodontal Disease and Diabetes Mellitus NCT06064786 | Fayoum University | — |
| Completed | GCF miRNA-223 , -214 Levels in Smokers and Nonsmokers Periodontitis Patients NCT06064799 | Fayoum University | — |
| Completed | The Flapless Approach in Periodontal Regeneration NCT05456555 | University of Turin, Italy | N/A |
| Unknown | Full Mouth Ultrasonic Debridement Carried Out Either by Piezoelectric or Magnetostrictive Device NCT05279950 | University of Siena | N/A |
| Completed | Advanced Platelet-rich Fibrin Combined With Open Debridement in Management of Suprabony Periodontal Defects NCT05730153 | October University for Modern Sciences and Arts | Phase 4 |
| Completed | Effect of Iodine Deficiency on Periodontitis NCT05724251 | Ataturk University | — |
| Unknown | Effects of Antibiotic Therapy on the Short and Long-term Results of Periodontitis Treatments NCT05065034 | University Hospital, Strasbourg, France | — |
| Completed | Early Versus Delayed Orthodontic Treatment After Periodontal Surgery on Periodontal Health in Periodontally Co NCT05466253 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Withdrawn | Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients. NCT05646459 | University of Nebraska | Phase 1 |
| Unknown | Clinical and Radiographic Evaluation of NIPSA Versus M-MIST in Treatment of Intra-osseous Defects NCT04149834 | Cairo University | N/A |
| Completed | Efficacy of Proanthocyanidins in Non-Surgical Periodontal Therapy NCT05015387 | Lithuanian University of Health Sciences | Phase 2 |
| Completed | Utilization of a Periodontal Endoscope in Nonsurgical Periodontal Therapy NCT05293301 | Louisiana State University Health Sciences Center in New Orleans | N/A |
| Completed | Locally Delivered Minocycline in Advanced Periodontitis NCT04076098 | Mahsa University | Phase 4 |
| Unknown | Garlic Product Impact on Periodontitis (GPIP) NCT03492723 | Hadassah Medical Organization | N/A |
| Completed | Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of Periodontitis NCT04264624 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Unknown | Evaluation of Multiple Subgingival Irrigations. NCT03432975 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Completed | Cleansing Efficacy of Waist-shaped Interdental Brushes. NCT03851757 | Medical University Innsbruck | N/A |
| Unknown | Protozoans in Biofilm From Patients With Periodontitis NCT03240666 | Central Hospital, Nancy, France | — |
| Unknown | Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome NCT03297749 | University College, London | — |
| Completed | Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis NCT03178838 | Central Hospital, Nancy, France | — |
| Completed | Association of Periodontitis With Oral Health Related Quality of Life NCT04240015 | Baskent University | — |
| Completed | Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients NCT03453476 | National University of Singapore | N/A |