NCT03453476

Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 51 (actual)
• Sponsor: National University of Singapore · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant. At baseline, 3rd month and 6th month, clinical parameters and cytokine pattern in gingival crevicular fluids (GCFs) were analysed.

Detailed description

Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed.

Conditions

• Periodontitis, Adult
• Periodontal Pocket
• Periodontitis
• Periodontal Attachment Loss

Interventions

Type	Name	Description
DEVICE	SRP and Fotosan 630	After isolating the test quadrants with cotton roll, toluidine blue was applied into the deep pockets (PD ≥ 4mm) at the test quadrants for 10 seconds, followed by inserting a perio tip (15 or 21 mm depending on the depth of the pocket) that connected to a LED emitting device, and light was emitted for 20 seconds. Toluidine blue in the deep pocket was removed by injecting normal saline into the pocket.

Timeline

• Start date: 2012-01-01
• Primary completion: 2013-03-31
• Completion: 2013-06-30
• First posted: 2018-03-05
• Last updated: 2018-03-05