NCT03297749

Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 102 (estimated)
• Sponsor: University College, London · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: —

Summary

The aim of this study is to investigate the systemic impact of periodontitis in patients with Metabolic Syndrome, by assessing measures of sub-clinical atherosclerosis and cardiovascular risk, microbial factors and host genetic variants, and to study the possible effect of mediators of inflammation and oxidative stress as links between the two conditions.

Detailed description

This is a cross-sectional study. 102 patients with metabolic syndrome will be recruited and will have periodontal and dental examination for diagnosis of caries and periodontal diseases. They will undergo blood, saliva, GCF and subgingival plaque sampling and a series of tests on cardiovascular disease, including measures of pulse-wave velocity,carotid intima-media thickness and echocardiography assessment. Statistical analysis will assess associations between dental diagnoses and metabolic, cardiovascular, inflammatory, genetic, microbial and cardiovascular risk outcomes.

Conditions

• Periodontitis, Adult
• Metabolic Syndrome

Interventions

Type	Name	Description
OTHER	Observational study (no intervention)	No interventions

Timeline

• Start date: 2015-07-01
• Primary completion: 2017-09-30
• Completion: 2020-12-31
• First posted: 2017-09-29
• Last updated: 2017-10-26

Locations

2 sites across 2 countries: Italy, United Kingdom