NCT06064786

Fetuin A Association in Periodontal Disease and Diabetes Mellitus

Evaluation of Fetuin-A and hsCRP Levels in Gingival Crevicular Fluid in Periodontitis Diabetic and Non-Diabetic Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Fayoum University · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Aim: The aim of the current study was to compare and correlate gingival crevicular fluid (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease. Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according to whether having type II diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. Clinical parameters for all groups were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.

Conditions

• Periodontitis, Adult

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	GCF levels of fetuin A and hsCRP evaluation	ELIZA kits are used for GCF levels of fetuin A and hsCRP evaluation

Timeline

• Start date: 2023-08-01
• Primary completion: 2023-09-15
• Completion: 2023-09-15
• First posted: 2023-10-03
• Last updated: 2023-10-03

Locations

1 site across 1 country: Egypt