| Not Yet Recruiting | Pattern And Outcome Of Neonatal Gastrointestinal Emergencies In Assiut University Children Hospital NCT07526636 | Assiut University | — |
| Not Yet Recruiting | Application of Transcriptome Sequencing Combined With Family-Based Whole Genome Sequencing in Improving Precis NCT06990334 | The First Hospital of Jilin University | — |
| Recruiting | Study of Normal Intestinal Development and Disease in Premature and Term Neonates NCT06681129 | Boston Children's Hospital | — |
| Not Yet Recruiting | Necrotizing Enterocolitis and Bowel Perforation in Very Preterm Infants - Long-term Follow up NCT06757582 | University Hospital of North Norway | — |
| Withdrawn | Phase I Clinical Study of Chondroitin Sulfate for Treatment of NEC NCT06547424 | Indiana University | Phase 1 |
| Active Not Recruiting | Milk Temperature Control and Necrotizing Enterocolitis Risk in Extremely Preterm Infants NCT06908239 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Recruiting | Impact of Standardized Skin-to-Skin Care on Clinical Outcomes in Infants Born ≤ 32 Weeks: A Multicenter Study NCT06672913 | Baskent University Ankara Hospital | N/A |
| Recruiting | Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Entero NCT06315738 | Noveome Biotherapeutics, formerly Stemnion | Phase 1 / Phase 2 |
| Unknown | Fecal Microbiota Transplantation (FMT) as a Prophylaxis of Necrotizing Enterocolitis (NEC) - Clinical Study NCT06333405 | Medical University of Warsaw | N/A |
| Unknown | Intestinal Perfusion After Feeding in Preterm and Term Infants NCT06319326 | The Hospital for Sick Children | — |
| Recruiting | Qualitative Study of Surgeons With Prospective Patient Follow-up NCT06032676 | University Hospital Southampton NHS Foundation Trust | — |
| Recruiting | PrePhage - Faecal Bacteriophage Transfer for Enhanced Gastrointestinal Tract Maturation in Preterm Infants NCT05272579 | Rigshospitalet, Denmark | EARLY_Phase 1 |
| Unknown | The Effect of Probiotics Added to the Mother's Diet on Preterm Babies NCT06118801 | Harran University | N/A |
| Not Yet Recruiting | PUFAs in Preterm Infants NCT06045130 | The First Hospital of Jilin University | — |
| Active Not Recruiting | RIC-NEC Randomized Controlled Trial NCT05279664 | The Hospital for Sick Children | Phase 2 |
| Unknown | Human Milk-derived Fortification in Preterm Infants NCT05228847 | University of Calgary | N/A |
| Unknown | Effect of Oral N-Acetyl Cysteine in Prevention of Necrotizing Enterocolitis in Preterm Neonates With Feeding I NCT06202911 | Ain Shams University | Phase 4 |
| Completed | Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis NCT07207915 | Sixth Affiliated Hospital, Sun Yat-sen University | — |
| Recruiting | Probiotic Supplementation in Extremely Preterm Infants in Scandinavia NCT05604846 | Region Stockholm | N/A |
| Completed | Comparative Effectiveness Trial for Diagnosis of Necrotizing Enterocolitis NCT05573113 | Children's Mercy Hospital Kansas City | N/A |
| Recruiting | Spectral Analysis of Bowel Sounds in Preterm Babies of Less Than 32 Weeks of Amenorrhea (WA) as Predictive Fac NCT05544097 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Effect of Pentoxifylline Versus Probiotic on Preterm Neonates With Necrotizing Enterocolitis NCT06422000 | Tanta University | Phase 3 |
| Unknown | Infant Formula Feeding and Necrotizing Enterocolitis in Newborns NCT05121753 | Neuroganics LLC | — |
| Terminated | Components of Metabolic Derangement and Paracentesis for Determination of Surgery in Preterm Neonates With Nec NCT06035848 | Gerardo Fernández Ortega | N/A |
| Recruiting | WithHolding Enteral Feeds Around Blood Transfusion (International) NCT05213806 | IWK Health Centre | N/A |
| Unknown | Bowel Preparation in Elective Pediatric Colorectal Surgery NCT03593252 | McMaster University | N/A |
| Active Not Recruiting | Identification of Clostridium Butyricum and Clostridium Neonatal in the Digestive Microbiota of Premature Infa NCT04584320 | Centre Hospitalier Universitaire de Nīmes | — |
| Withdrawn | a Clinical Risk Score to Predict Bloody Stool in Neonates NCT05055817 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Unknown | Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enteroc NCT04972734 | University Hospital, Clermont-Ferrand | N/A |
| Recruiting | Primary Anastomosis Versus Enterostomy in the Surgical Treatment of Necrotising Enterocolitis NCT04912453 | The University of Hong Kong | N/A |
| Withdrawn | Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis NCT04921696 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Completed | The Efect of Azithromicyn on Bronchopulmonary Displasia in Extremely Preterm and Very Preterm Infant NCT05311228 | Indonesia University | Phase 4 |
| Completed | Efficacy Of Oral Melatonin To Prevent Necrotizing Enterocolitis NCT05033639 | Ilocos Training and Regional Medical Center | Phase 1 / Phase 2 |
| Unknown | Assessment of Score System of Surgery in Necrotizing Enterocolitis(NEC) Patients NCT04795453 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Unknown | Temperature of Extremities and Necrotizing Enterocolitis NCT04801537 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Unknown | Treatment of Classic Mid-trimester PPROM by Means of Continuous Amnioinfusion NCT04696003 | Martin-Luther-Universität Halle-Wittenberg | Phase 3 |
| Unknown | The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants NCT04541771 | Children's Hospital and Institute of Child Health, Multan | Phase 2 |
| Completed | The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. NCT04020939 | St. Justine's Hospital | N/A |
| Recruiting | Early Routine vs. Selective Human Milk Fortification in Extremely Preterm Infants NCT04284280 | Crouse Hospital | N/A |
| Completed | NEC Thermography Infrared Imaging Study NCT03994341 | Ottawa Hospital Research Institute | — |
| Active Not Recruiting | IBP-9414 for the Prevention of Necrotizing Enterocolitis - The Connection Study NCT03978000 | Infant Bacterial Therapeutics | Phase 3 |
| Completed | Bovine Colostrum as a Human Milk Fortifier for Preterm Infants NCT03822104 | Per Torp Sangild | N/A |
| Completed | Incidence, Risk Factors, Severity and Prognosis of Necrotizing Enterocolitis in Turkey NCT04344639 | Turkish Neonatal Society | — |
| Active Not Recruiting | Human Milk Fortification in Extremely Preterm Infants NCT03797157 | Thomas Abrahamsson, MD, PhD | Phase 2 / Phase 3 |
| Completed | Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants NCT04304807 | Ain Shams University | Phase 4 |
| Active Not Recruiting | A Cohort Study of the Intestinal Microbiota of Premature Infants NCT03717584 | University of California, Davis | — |
| Completed | Alteration of Stool Microbiota in Preterm Infants With Anemia NCT03554278 | University of Texas Southwestern Medical Center | — |
| Unknown | The Impact of Docosahexaenoic Acid on the Prevention of Necrotizing Enterocolitis in Preterm Neonates NCT03700957 | Ain Shams University | N/A |
| Active Not Recruiting | A Genome-Wide Association Study for Neonatal Diseases NCT04074824 | Chinese University of Hong Kong | — |
| Unknown | Necrotizing Enterocolitis in Fetuses With Intrauterine Growth Restriction NCT03869827 | Hospices Civils de Lyon | — |
| Recruiting | Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infant NCT03631979 | Uppsala County Council, Sweden | N/A |
| Unknown | A Panel of Biomarkers in Diagnosing Late-onset Neonatal Sepsis and Necrotizing Enterocolitis in Sibu Hospital NCT03578978 | Clinical Research Centre, Malaysia | — |
| Unknown | Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies. NCT03431558 | Aga Khan University | Phase 3 |
| Unknown | Ultrasound, Doppler ,and Calprotectin in Necrotizing Enterocolitis Diagnosis NCT03257553 | Assiut University | N/A |
| Completed | Bovine Colostrum as a Fortifier Added to Human Milk for Preterm Infants NCT03537365 | Per Torp Sangild | N/A |
| Recruiting | Early Predictors of Necrotizing Enterocolitis in Neonates NCT03210831 | Nationwide Children's Hospital | — |
| Terminated | Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation NCT03320785 | Per Torp Sangild | — |
| Completed | MISA to NRDS：a Multicenter Study in China NCT04077333 | Peking University Third Hospital | N/A |
| Completed | Risk Factors for Poor Prognosis in Neonatal Necrotizing Enterocolitis NCT07249697 | Guangzhou Women and Children's Medical Center | — |
| Completed | Bovine Colostrum for Preterm Newborns NCT03085277 | Per Torp Sangild | N/A |
| Active Not Recruiting | RBC Irradiation, Anemia and Gut Injury NCT02741648 | Emory University | — |
| Unknown | Heat Killed Probiotics in the Prevention of Necrotizing Enterocolitis NCT02796703 | Shaare Zedek Medical Center | Phase 2 |
| Completed | IBP-9414 for the Prevention of Necrotizing Enterocolitis NCT02472769 | Infant Bacterial Therapeutics | Phase 2 |
| Unknown | Evaluation of Abdominal Tissue Oxygenation in Premature Infants Using Near Infrared Spectroscopy NCT01855347 | Brigham and Women's Hospital | — |
| Completed | Pilot Study of the Feasibility of Feeding Preterm Infants With Fresh Versus Frozen Mother's Own Breast Milk in NCT03258957 | Huiqing Sun | N/A |
| Unknown | The Impact of Different Feeding Strategies During Packed Red Cell Transfusion on Intestinal Oxygenation NCT02733718 | Marmara University | N/A |
| Unknown | Evaluation of Feeding Intolerance in Premature Infants Using Near Infrared Spectroscopy NCT02534090 | Brigham and Women's Hospital | — |
| Completed | Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus NCT03551600 | University of Utah | — |
| Unknown | Simulated Amniotic Fluid Solution in Neonates Recovering From GIT Surgeries NCT03302338 | Rania Ali El-Farrash | Phase 1 |
| Completed | Clostridium and Neonatal Necrotizing Enterocolitis Pathophysiology : Clinical and Molecular Approaches NCT02444624 | Nantes University Hospital | — |
| Completed | PREMAPROB. Probiotics to Prevent Necrotizing Enterocolitis NCT06501404 | José Antonio Hurtado Suazo | N/A |
| Completed | SMA Flow Patterns in Neonatal Transfusion NCT02347475 | University of Calgary | — |
| Withdrawn | Prediction of NEC With Urinary iFABP NCT01805206 | Loma Linda University | Phase 2 |
| Unknown | The Efficacy and Mechanisms of Oral Probiotics in Preventing Necrotizing Enterocolitis NCT02552706 | Shenzhen Bao'an Maternal and Child Health Hospital | N/A |
| Completed | Placental Transfusion Project for Preterm Infants NCT02400697 | Indiana University | — |
| Unknown | Simulated Amniotic Fluid In Preventing Feeding Intolerance and Necrotizing Enterocolitis VLBW Neonates NCT02405637 | Rania Ali El-Farrash | Phase 1 |
| Completed | Feeding Bovine Colostrum to Preterm Infants NCT02054091 | Per Torp Sangild | N/A |
| Completed | STP206 for the Prevention of Necrotizing Enterocolitis (NEC) NCT01954017 | Leadiant Biosciences, Inc. | Phase 1 |
| Completed | Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus NCT01958320 | University of California, San Francisco | Phase 2 |
| Completed | Splanchnic Oxygenation Response to Feeds in Preterm Neonates: Effect of Red Blood Cell Transfusion NCT03643458 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Speed of Increasing Milk Feeds Trial NCT01727609 | University of Oxford | N/A |
| Completed | Splanchnic Oxygenation After the First Enteral Feed in Preterm Infants: Prediction of Feeding Tolerance. NCT02383264 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Ente NCT01735578 | University of Utah | — |
| Unknown | The Effects of Synbiotics on Morbidity and Mortality in Preterm Infants NCT01807858 | Dr. Sami Ulus Children's Hospital | N/A |
| Completed | Enteral Administration of Docosahexaenoic Acid to Prevent Necrotizing Enterocolitis in Preterm Neonates NCT01745510 | Coordinación de Investigación en Salud, Mexico | Phase 1 / Phase 2 |
| Completed | Role of Probiotics for Prevention of NEC in Preterm VLBW Infants NCT02650869 | Sylhet M.A.G.Osmani Medical College | Phase 3 |
| Completed | Prophylactic Probiotics to Extremely Low Birth Weight Prematures NCT01603368 | Ostergotland County Council, Sweden | Phase 2 |
| Terminated | Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates NCT01735552 | University of Utah | — |
| Completed | Effects of Oral Probiotic Supplementation on the Clinical Status of Very-low-birth-weight Preterm Neonates. NCT02073214 | IBSS Biomed S.A. | N/A |
| Completed | Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants NCT01531179 | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 3 |
| Completed | Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants NCT01868737 | University of Stellenbosch | Phase 3 |
| Withdrawn | A Multi-strain Synbiotic Versus a Multi-strain Probiotic in Premature Infants NCT01337921 | University of Nebraska | N/A |
| Unknown | Monitoring Necrotizing Enterocolitis in Premature Infants NCT01287559 | Spectros Corporation | — |
| Unknown | Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants NCT01315821 | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 3 |
| Completed | Defining the Intestinal Microbiota in Premature Neonates NCT01102738 | Imperial College London | — |
| Completed | Metronidazole Pharmacokinetics (PK) in Premature Infants NCT01222585 | Michael Cohen-Wolkowiez | Phase 1 |
| Unknown | Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonat NCT02050971 | Pomeranian Medical University Szczecin | Phase 1 |
| Completed | Infloran® for Prevention of Necrotizing Enterocolitis NCT01751477 | Medical University of Vienna | — |
| Terminated | Therapeutic Controlled Hypothermia in the Treatment of Neonates With Severe Necrotizing Enterocolitis NCT01330576 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Unknown | IRT in Infants With Intestinal Perforation NCT01530828 | Children's Hospitals and Clinics of Minnesota | — |
| Completed | Prediction of Feeding Problems in Prostaglandin-dependent Prematurely Born Infants With Congenital Heart Disea NCT01126372 | University of Utah | — |
| Terminated | Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Inflammatory Syndromes NCT01106209 | University of Utah | — |
| Completed | Probiotics to Prevent NEC - a Historical Control Study NCT01670916 | Rigshospitalet, Denmark | — |
| Completed | Optimising Newborn Nutrition During Therapeutic Hypothermia. NCT03278847 | Imperial College London | — |
| Completed | Enteral Granulocyte Colony Stimulating Factor and Erythropoietin Early in Life Increases Feeding Tolerance in NCT01441427 | Ain Shams University | Phase 1 / Phase 2 |
| Terminated | Necrotizing Enterocolitis (Nec) and B. Lactis in Premature Babies NCT00977912 | Société des Produits Nestlé (SPN) | N/A |
| Completed | Early Provision of Enteral Microlipid and Fish Oil to Infants With Enterostomy NCT01306838 | Wake Forest University | EARLY_Phase 1 |
| Terminated | Anti-inflammatory Treatment at the Onset of Necrotizing Enterocolitis (NEC) in Preterm Infants NCT01156480 | Endeavor Health | N/A |
| Terminated | Defining Normal Citrulline Levels as a Diagnostic Tool for Screening of Gastrointestinal Disease in Premature NCT01062828 | University of Miami | — |
| Unknown | Prebiotics in the Prevention of Necrotizing Enterocolitis NCT00437567 | Shaare Zedek Medical Center | Phase 2 |
| Unknown | Administration of Arginine Supplementation in Preterm Infants NCT01336998 | Alexandra Hospital, Athens, Greece | N/A |
| Terminated | Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants NCT01062815 | University of Miami | N/A |
| Completed | Transfusions and Nitric Oxide Level in Preterm Infants NCT00787124 | Duke University | — |
| Completed | Pharmacokinetic (PK) and Safety Study of Meropenem in Young Infants With Intra-abdominal Infections NCT00621192 | The Emmes Company, LLC | Phase 1 / Phase 2 |
| Completed | Collaborative Research Group for Necrotizing Enterocolitis NCT00828451 | Washington University School of Medicine | N/A |
| Terminated | Probiotic Administartion to Mothers of Preterm Infants to Prevent Necrotizing Enterocolitis and Sepsis NCT00835874 | Tel-Aviv Sourasky Medical Center | N/A |
| Unknown | A Biologic Validation of Biomarkers of Progressive NEC & Sepsis NCT00588718 | R. Lawrence Moss | — |
| Completed | Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis NCT00707785 | Johns Hopkins University | Phase 3 |
| Completed | Intragastric and Peritoneal Microdialysis in Infants With Necrotizing Enterocolitis (NEC) NCT00332592 | Odense University Hospital | — |
| Unknown | Cysteine Supplementation in Critically Ill Neonates NCT00254176 | University of California, Los Angeles | Phase 2 / Phase 3 |
| Completed | Brain Manganese Deposition in High Risk Neonates NCT00392977 | Vanderbilt University | — |
| Completed | Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children NCT00392730 | Vanderbilt University | — |
| Completed | Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology NCT00315263 | Children's Mercy Hospital Kansas City | — |
| Completed | Lactulose Supplementation in Premature Infants NCT00616876 | Bnai Zion Medical Center | Phase 2 |
| Completed | Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocoli NCT01340469 | King Chulalongkorn Memorial Hospital | Phase 3 |
| Unknown | Pentoxifylline in the Treatment of NEC in Premature Neonates NCT00271336 | Shaare Zedek Medical Center | Phase 2 |
| Unknown | Intestinal Failure in Necrotising Enterocolitis NCT01441739 | Maastricht University Medical Center | — |
| Unknown | Necrotizing Enterocolitis (NEC) Surgical Database NCT00120159 | Boston Children's Hospital | — |
| Completed | Effects of Delayed Cord Clamping in Very Low Birth Weight Infants NCT00840983 | University of Rhode Island | Phase 1 |
| Completed | Comparison of Two Surgical Treatments for Necrotizing Enterocolitis in Human Infants NCT00252681 | Yale University | N/A |
| Completed | Study of the Relationship Between Feeding and Late Onset Sepsis and/or Necrotizing Enterocolitis in Low Birth NCT00005888 | National Center for Research Resources (NCRR) | N/A |
| Completed | Role of Epidermal Growth Factor (EGF) in Development of Necrotizing Enterocolitis NCT00059449 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | — |