NCT00059449

Role of Epidermal Growth Factor (EGF) in Development of Necrotizing Enterocolitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 372 (estimated)
• Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NIH
• Sex: All
• Age: 72 Hours
• Healthy volunteers: Not accepted

Summary

Necrotizing enterocolitis (NEC) is a serious gastrointestinal disorder that primarily affects preterm infants. About 10% of babies less than 32 weeks gestation at birth will develop it. Overall, 30% of babies who develop NEC will die from it, with many others developing long term gastrointestinal problems. The most important factor in its development is a premature intestinal tract. Epidermal growth factor (EGF) is an important growth factor in the development and maintenance of the gastrointestinal tract. This study will look for a relationship between EGF levels in premature babies and the development of NEC.

Conditions

• Necrotizing Enterocolitis
• Premature Birth

Timeline

• First posted: 2003-04-29
• Last updated: 2010-01-13

Locations

3 sites across 1 country: United States