| Not Yet Recruiting | Serious Game Rehabilitation and Brain Plasticity in MS NCT07474129 | Lille Catholic University | N/A |
| Not Yet Recruiting | A Study on the Safety and Tolerability of Universal STAR-T Cell Therapy for Multiple Sclerosis. NCT07523100 | Daishi Tian | Phase 1 |
| Recruiting | Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Anti NCT07526493 | Tongji Hospital | Phase 1 |
| Not Yet Recruiting | MRI-Based Lesion Differentiation in Older Patients With Multiple Sclerosis NCT07444047 | Oslo University Hospital | — |
| Recruiting | Effect of Music Therapy on Pain in People With Multiple Sclerosis NCT06800144 | Istanbul Bilgi University | N/A |
| Not Yet Recruiting | A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Ther NCT07341828 | Huashan Hospital | Phase 1 |
| Completed | Prevalence of Periodontitis in Egyptian Multiple Sclerosis Patients. NCT07195110 | Cairo University | — |
| Recruiting | Vista Protein Expression of Monocyte and T Cell Subsets in Multiple Sclerosis and Its Clinical Correlation NCT06957145 | Koç University | — |
| Recruiting | A Study of LCAR-AIO CAR-T Cells for Treating Relapsed/Refractory Neurological Autoimmune Diseases NCT06869278 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 1 |
| Enrolling By Invitation | Evaluation of the Efficacy of Transcranial Direct Current Stimulation in Reducing Fatigue and Improving Qualit NCT06873464 | European University of Madrid | N/A |
| Recruiting | Escalation vs. Induction Therapy Strategy in Patients With Early-Onset MS After Age 50 NCT07313462 | University Hospital, Strasbourg, France | — |
| Recruiting | A Palliative Care Model Impact on Knowledge and Attitudes NCT06860932 | Hunter College of City University of New York | N/A |
| Active Not Recruiting | Effect of Motor Cognitive Interference on Cognition and Quality of Life on Patients with Multiple Sclerosis NCT06839924 | Cairo University | N/A |
| Completed | PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF NCT06683612 | Contineum Therapeutics | Phase 1 |
| Not Yet Recruiting | Pilot of the Virtual Memory Attention and Problem Solving Skills Intervention for Persons With Multiple Sclero NCT06709768 | University of Texas at Austin | N/A |
| Not Yet Recruiting | Enhancing Quality of Life in MS Patients Through Tailored Therapeutic Education NCT06450600 | Akhrif Iman | N/A |
| Not Yet Recruiting | Home-based Balance Training in Adults With Multiple Sclerosis NCT06412003 | University of Vermont | N/A |
| Completed | Mood Disorders in Multiple Sclerosis Patients NCT06652308 | Islamic Azad University, Sanandaj | — |
| Completed | The Effect of Aerobic Exercise on an Elliptical Trainer Versus a Treadmill, in People With Multiple Sclerosis NCT06583967 | Soroka University Medical Center | N/A |
| Active Not Recruiting | An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Thi NCT06053749 | Bayer | — |
| Recruiting | A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy NCT06249438 | RenJi Hospital | Phase 1 |
| Recruiting | Increasing Physical Activity for Adults With Multiple Sclerosis (MS) NCT06270641 | University of Washington | N/A |
| Recruiting | Sun Yat-Sen Cohort of CNS Idiopathic Inflammatory Demyelinating Diseases NCT06541626 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Active Not Recruiting | Assessment of the Quality of Life of Multiple Sclerosis Patients Treated With Ofatumumab in Real-life in Franc NCT06157086 | Novartis Pharmaceuticals | — |
| Recruiting | Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy NCT05359653 | University of California, San Francisco | Phase 1 / Phase 2 |
| Recruiting | Multimodal Imaging Signatures of the Biological Mechanisms Underlying Neurodegeneration in Multiple Sclerosis NCT05633875 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers NCT05395624 | Ashvattha Therapeutics, Inc. | Phase 1 / Phase 2 |
| Completed | Physical Activity in Persons Newly Diagnosed With Multiple Sclerosis NCT05641532 | University of Alabama at Birmingham | N/A |
| Completed | Neurostatus-SMARTCARE in Comparison to Standard Neurostatus-EDSS® NCT05575843 | University Hospital, Basel, Switzerland | N/A |
| Recruiting | Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences NCT04819737 | University Hospital, Basel, Switzerland | N/A |
| Completed | A Study to Explore Association Patterns Between Digital Outcome Assessments From the Konectom™ Platform and Ma NCT05106465 | Biogen | — |
| Terminated | A Study to Evaluate the Safety, Tolerability, Kinetics, Biodistribution and Repeatability of 11C-BMS-986196 Af NCT05064436 | Bristol-Myers Squibb | Phase 1 |
| Terminated | Next-Gen MS: Feed-forward PRO Data for MS Research NCT04907305 | EMD Serono Research & Development Institute, Inc. | — |
| Active Not Recruiting | Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Scl NCT04926818 | Novartis Pharmaceuticals | Phase 3 |
| Terminated | COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders NCT05000216 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Terminated | Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2)-Related Multiple Sclerosis (MS) Vaccination NCT05197699 | Biogen | — |
| Unknown | Comparing the Safety and Benefit of Natalizumab (Tysabri®) At-home Infusion vs At-hospital Infusion in Multipl NCT04777539 | Nantes University Hospital | — |
| Completed | MS PATHS COVID-19 Questionnaire Data Linkage Sub-Study NCT05058729 | Biogen | — |
| Completed | Assessment of ANK-700 in Patients With Relapsing Remitting Multiple Sclerosis NCT04602390 | Anokion SA | Phase 1 |
| Terminated | Safety and Effectiveness of Nabiximols Oromucosal Spray as Add-on Therapy in Participants With Spasticity Due NCT04203498 | Jazz Pharmaceuticals | Phase 3 |
| Recruiting | A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young A NCT04121468 | The Hospital for Sick Children | Phase 1 / Phase 2 |
| Completed | Long-Term Outcomes and Durability of Effect Following Treatment With Cladribine Tablets for MS (CLASSIC-MS) NCT03961204 | EMD Serono Research & Development Institute, Inc. | Phase 4 |
| Completed | A Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administrati NCT03972306 | Hoffmann-La Roche | Phase 1 |
| Completed | A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of NCT03737812 | AbbVie | Phase 2 |
| Completed | A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Relapsing Forms of M NCT03737851 | AbbVie | Phase 2 |
| Unknown | Chronic Inflammatory Disease, Lifestyle and Risk of Disease NCT03456206 | University of Southern Denmark | — |
| Unknown | Characterization of Cortical Injury in Early MS Patients: a 7T MRI Study NCT03624296 | Assistance Publique Hopitaux De Marseille | N/A |
| Recruiting | Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis NCT05177523 | University Hospital, Basel, Switzerland | — |
| Completed | Sequential Natalizumab - Alemtuzumab Therapy in Patients With Relapsing Forms of Multiple Sclerosis NCT03135249 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculograp NCT04705610 | Association de Recherche Bibliographique pour les Neurosciences | N/A |
| Completed | Assessment of Tecfidera® in Radiologically Isolated Syndrome (RIS) NCT02739542 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | Emotional Processing in Multiple Sclerosis / Clinically Isolated Syndrome: A Neuropsychological fMRI-study NCT02695394 | Charite University, Berlin, Germany | — |
| Completed | An Observational Pilot Study of Lumosity Computerized Cognitive Training in Subjects With Multiple Sclerosis NCT02612935 | Lumos Labs, Inc. | — |
| Completed | Clinical Efficacy of Autologous Mesenchymal Bone Marrow Stem Cells in Active & Progressive Multiple Sclerosis NCT02166021 | Dimitrios Karussis | Phase 2 |
| Unknown | Physical Capacity and Rehabilitation of Patients With Multiple Sclerosis NCT02352194 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple NCT02308579 | University at Buffalo | — |
| Withdrawn | Alternative Treatment Paradigm for Natalizumab Trial NCT01710228 | University of Texas Southwestern Medical Center | Phase 2 |
| Completed | Electric Stimulation of the Eye to Improve Vision After Trauma NCT02019927 | Wills Eye | N/A |
| Completed | Pilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ)Versus ACTHar Gel Five Days SQ for the Treatment o NCT01888354 | The University of Texas Health Science Center, Houston | Phase 4 |
| Recruiting | Pregnancy Cohort in Multiple Sclerosis (MS) NCT05010902 | Charite University, Berlin, Germany | — |
| Completed | Longitudinal Therapeutically Non-interventional Study of MSRV-Env Burden in Patients With Multiple Sclerosis D NCT01804647 | GeNeuro Innovation SAS | — |
| Completed | Effect of Vitamin D Replacement on Immune Function and Cognition in MS Patients NCT01952483 | American University of Beirut Medical Center | — |
| Completed | Effect of Guided Imagery on Well-being in Patients With Multiple Sclerosis NCT03177655 | University of California, San Diego | N/A |
| Completed | PRISM Registry: Pseudobulbar Affect Registry Series NCT01366027 | Avanir Pharmaceuticals | — |
| Unknown | Cohort Study of Clinically Isolated Syndrome and Early Multiple Sclerosis NCT01371071 | Charite University, Berlin, Germany | — |
| Terminated | The Inflammatory Process and the Medical Imaging in Patients With an Inflammatory Disease of the Central Nervo NCT01567553 | Rennes University Hospital | — |
| Completed | Avonex®: Safety, Blood Levels and Effects NCT01863069 | Trio Medicines Ltd. | Phase 1 |