| Not Yet Recruiting | ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral NCT06167213 | Edwards Lifesciences | N/A |
| Recruiting | Abbott Cephea Mitral Valve Disease Registry NCT07069673 | Abbott Medical Devices | — |
| Recruiting | Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve NCT07097740 | Mitrassist Lifesciences Limited Co., Ltd. | N/A |
| Recruiting | Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease NCT07267117 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Terminated | NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study NCT06269640 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Not Yet Recruiting | LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY NCT06547788 | Ottawa Heart Institute Research Corporation | N/A |
| Recruiting | Safety and Efficacy of the CoolCryo System for Cardiac Cryoablation in the Treatment of Atrial Fibrillation NCT06557616 | Medinice S.A. | — |
| Recruiting | European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study NCT06235385 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Non-invasive Prediction of Fluid and Noradrenaline Responsiveness Using the Carotid Wave Intensity. NCT06197321 | Catharina Ziekenhuis Eindhoven | — |
| Unknown | Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer NCT06112561 | George Papanicolaou Hospital | N/A |
| Not Yet Recruiting | EXPLORE MRace: Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Us NCT06113354 | Polares Medical SA | N/A |
| Unknown | Retrospective Clinical Data Collection on Carbomedics OptiForm Mitral Heart Valve NCT05898230 | Corcym S.r.l | — |
| Recruiting | PROMISE: Percutaneous peRipheral cannulatiOn for Minimally-InvaSive Heart Valve surgEry NCT05961150 | Universitätsklinikum Hamburg-Eppendorf | — |
| Not Yet Recruiting | Munich Transcatheter Mitral Valve Safety and Effectiveness NCT05871983 | P+F Products + Features GmbH | N/A |
| Recruiting | The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surg NCT06001489 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Unknown | Clinical Investigation for the Foldax Tria Mitral Valve- India NCT06191718 | Foldax, Inc | N/A |
| Unknown | Evaluation of Mitral Valve Insufficiency Under General Anesthesia NCT05736289 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Unknown | Bleeding and Blood Transfusion in MVR NCT05594420 | Assiut University | — |
| Completed | Respired Gases in Patients Post Cardiac Surgery NCT05531253 | University of Oxford | — |
| Unknown | Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy NCT05892588 | Azienda Ospedaliero-Universitaria Careggi | — |
| Completed | The Role of Left Atrial Fibrosis in Mitral Valve Repair Surgery (ALIVE Trial) NCT05345730 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | Philips Intracardiac Echocardiography (ICE) Clinical Registry NCT04950192 | Philips Clinical & Medical Affairs Global | — |
| Recruiting | Evaluation of the Elasticity of the Mitral Valve NCT06153563 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Completed | Robustness Check of Placement and Measurement Algorithms for Blood Flow Measurement on Common Carotid Artery NCT05193760 | Catharina Ziekenhuis Eindhoven | — |
| Recruiting | Mitral Valve Screening Survey NCT04736667 | Medstar Health Research Institute | — |
| Active Not Recruiting | Prospective Multicenter Study on Mitral Annular Disjunction NCT04916535 | University Hospital of Ferrara | N/A |
| Recruiting | Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease ( NCT04954404 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | Autonomous Robotics for Transcatheter Cardiac Procedures NCT04787757 | Università Vita-Salute San Raffaele | — |
| Recruiting | Hamburg TranscathEteR Mitral Valve REplacement RegiStry NCT04914468 | Universitätsklinikum Hamburg-Eppendorf | — |
| Recruiting | The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves). NCT04408430 | Mayra Guerrero | N/A |
| Completed | Treatment With 5-AminoLEvuliNic Acid Before Cardiac Surgery NCT07027670 | University of Oxford | Phase 2 |
| Unknown | Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement NCT04717570 | Foldax, Inc | N/A |
| Unknown | VIenna Pilot Study for Automated Annular Suturing Technology NCT04659655 | Medical University of Vienna | N/A |
| Unknown | SATURN Transcatheter Mitral Valve Replacement for Functional Mitral Regurgitation NCT04464876 | InnovHeart | N/A |
| Completed | Effect of Early Mobilization on Length of Stay, Recovery and Readmission Rate of Patients After CABG or AVR/MV NCT04401397 | Dimitris Chatzitheodorou | N/A |
| Unknown | Minimal Invasive Mitral Valve Replacement Versus Conventional Median Sternotomy Approach NCT03195595 | Assiut University | — |
| Recruiting | Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System NCT04190602 | NeoChord | — |
| Terminated | Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation NCT04098328 | Polares Medical SA | — |
| Active Not Recruiting | A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral NCT04147884 | Boston Scientific Corporation | N/A |
| Completed | Intraoperative Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Out NCT04045340 | Scientific Institute San Raffaele | — |
| Completed | Are the Results of Minimally Invasive Mitral Valve Repair Still Satisfactory When Looked at Very Long-term? NCT05836558 | Michele De Bonis | — |
| Completed | Quality of Life After Cardiac Surgery NCT04231461 | Papworth Hospital NHS Foundation Trust | — |
| Unknown | The Conveyor Study NCT03893578 | Synecor, LLC | N/A |
| Completed | Effects of Microplegia on Transfusion Rates After Cardiac Surgery NCT05076604 | Washington University School of Medicine | Phase 4 |
| Completed | Durability at 20 Years of Quadrangular Resection With Annular Plication for Mitral Regurgitation NCT05724537 | Michele De Bonis | — |
| Unknown | Enhanced Recovery After Cardiac Surgery NCT03859102 | James Cook University Hospital | N/A |
| Completed | Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification NCT03539458 | Abbott Medical Devices | N/A |
| Unknown | Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Sur NCT03574311 | Turku University Hospital | Phase 4 |
| Recruiting | The Study on the Use of "UniLine" Bioprosthesis in the Treatment of Isolated Aortic and Mitral Valve Diseases NCT06025149 | Closed Joint-Stock Company NeoCor | — |
| Unknown | Patient Specific Mitral Valve Modeling for Surgical Planning and Training NCT03609931 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Completed | ESP vs ESP With PECS NCT03592485 | Medical University of Lublin | Phase 4 |
| Unknown | Primary Mitral Regurgitation Repair NCT04067635 | Eric Y. Yang, MD PhD | — |
| Completed | Registry for Mitral Valve Surgery at Department of Cardiac Surgery University Hospital of Basel/ Switzerland NCT03587688 | University Hospital, Basel, Switzerland | — |
| Active Not Recruiting | AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System NCT03339115 | Cardiovalve Ltd. | N/A |
| Terminated | Improving Mitral Repair for Functional Mitral Regurgitation NCT03366649 | Emory University | N/A |
| Completed | Warfarin Initiation in Mechanical Mitral Valve Replacement Patients NCT04235569 | Sarah Sabry Hashem | Phase 4 |
| Completed | Postoperative Analgesia After Minithoracotomy NCT03415555 | Medical University of Lublin | Phase 4 |
| Active Not Recruiting | PARTNER 3 Trial - Mitral Valve in Valve NCT03193801 | Edwards Lifesciences | N/A |
| Completed | Clinical Pharmacist-led Inpatient Anticoagulation Stewardship Program NCT03812848 | Ain Shams University | N/A |
| Completed | Frailty in Elderly Patients Receiving Surgical or Percutaneous Procedures for Valvular Disorders NCT03365453 | University Hospital of Ferrara | N/A |
| Unknown | Caisson Transcatheter Mitral Valve Replacement (TMVR) NCT03661398 | Caisson Interventional LLC | N/A |
| Completed | Early Initiation of Post Sternotomy CArdiac Rehabilitation NCT03223558 | University Hospitals Coventry and Warwickshire NHS Trust | N/A |
| Completed | PRESERVE-MITRAL Post-Market Registry NCT03283722 | Medtronic Cardiac Surgery | — |
| Completed | PRediction of Early PostoperAtive Right vEntricular Failure in Mitral Valve Replacement/Repair Patients NCT03438825 | Semmelweis University Heart and Vascular Center | — |
| Recruiting | Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery NCT02925819 | French Cardiology Society | — |
| Completed | Percutaneous Plug-based Arteriotomy Closure Device Use in Minimally Invasive Mitral Valve Surgery NCT03697941 | Karolinska University Hospital | — |
| Active Not Recruiting | Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patient NCT03444259 | University of Turku | — |
| Completed | HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve NCT02097420 | Abbott Medical Devices | N/A |
| Completed | Mitral Implantation of TRAnscatheter vaLves NCT02370511 | Mayra Guerrero | N/A |
| Completed | Assessment of Sustained Systolic-to-diastolic Flexibility of the Mitral Valve Annulus With the Sorin MEMO 3D M NCT01987635 | University Hospital, Ghent | N/A |
| Withdrawn | Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin NCT01849757 | University of Saskatchewan | N/A |
| Completed | Clinical Evaluation of a Modular Extracorporeal Circulation Circuit NCT02000544 | AHEPA University Hospital | N/A |
| Completed | Symptomatic Pulmonary Arterial Hypertension After Mitral Valve Surgery NCT01646541 | Duke University | — |
| Completed | Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation NCT03239262 | University Hospital Ostrava | N/A |
| Terminated | Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometr NCT01281397 | University of Zagreb | — |
| Completed | The Effectiveness of Respiratory Physiotherapy in Mitral Valve Surgery NCT02278835 | University of Sao Paulo General Hospital | N/A |
| Terminated | Artificial Valve Endocarditis Reduction Trial NCT00590889 | Abbott Medical Devices | N/A |