NCT06153563

Evaluation of the Elasticity of the Mitral Valve

Evaluation of the Elasticity of the Mitral Valve Chordae by Uniaxial Traction in the Context of Mitral Valve Regurgitation With a Comparison of the Results: Mitral Valve Prolapse vs Restriction of Mitral Valve Movement

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Saint Etienne · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Not accepted

Summary

There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen human tissues. The objective is to determine mechanobiological and histological characteristics of the mitral valve chords in living humans, as well as to compare differences in elasticity in different groups (Group A: patients with mitral valve prolapse versus Group B: patients with restrictive ischemic mitral valve).

Detailed description

The prospective study will be conducted on 20 patients, who will be selected consecutively without randomization. The inclusion and exclusion criteria are determined. The harvested tissue will not be frozen and will kept in natural conditions as close as possible.

Conditions

• Mitral Valve Disease

Interventions

Type	Name	Description
OTHER	Data collection on patient history and intraoperative results.	Data collection on patient history and intraoperative results.

Timeline

• Start date: 2021-10-18
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2023-12-01
• Last updated: 2025-01-06

Locations

1 site across 1 country: France