NCT03444259

Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,001 (actual)
• Sponsor: University of Turku · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Detailed description

The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.

Conditions

• Atrial Fibrillation
• Coronary Artery Disease
• Aortic Valve Stenosis
• Aortic Valve Disease
• Mitral Valve Disease
• Cardiac Arrythmias
• Cardiac Tumor
• Cardiac Surgery

Interventions

Type	Name	Description
PROCEDURE	Cardiac surgery	Open heart surgery

Timeline

• Start date: 2016-02-01
• Primary completion: 2026-12-31
• Completion: 2029-12-31
• First posted: 2018-02-23
• Last updated: 2024-05-08

Locations

1 site across 1 country: Finland