Melasma

118 registered clinical trials studyying Melasma — 21 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Clinical Efficacy and Mechanisms of a Topical Azone-Tranexamic Acid-Aloe Polysaccharide Gel in the Treatment o NCT07530016	The First Affiliated Hospital of Xinxiang Medical College	N/A
Not Yet Recruiting	Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma NCT07495748	Foundation University Islamabad	N/A
Not Yet Recruiting	Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma NCT07485777	Foundation University Islamabad	N/A
Enrolling By Invitation	Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study NCT07296549	Venus Research Center	—
Not Yet Recruiting	Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma NCT07522788	Hayatabad Medical Complex	Phase 4
Not Yet Recruiting	Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to NCT07429786	Cosmetique Active International	N/A
Not Yet Recruiting	Secretome TGF Beta 3 NCT07137130	Indonesia University	N/A
Not Yet Recruiting	Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Mela NCT07448415	Assiut University	Phase 2 / Phase 3
Not Yet Recruiting	Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES NCT07121439	Dr.dr.Irma Bernadette, SpKK (K)	N/A
Not Yet Recruiting	Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face NCT07060157	Assiut University	N/A
Enrolling By Invitation	Comparative Effects Of Trichloroacetic Chemical Peel And Fractional Laser NCT07036302	Jose Roberto Cortelli	N/A
Not Yet Recruiting	Topical Metformin Versus Topical Ketotifen in Melasma Treatment NCT06942390	Assiut University	Phase 2
Completed	Azelaic Acid 20% vs Hydroquinone 4% in Epidermal Melasma NCT07327983	Gujranwala medical college District Headquarters Hospital, Gujranwala	N/A
Recruiting	Oral Metformin for Treating Melasma in Latin American Women NCT06845540	University of Puerto Rico	Phase 1 / Phase 2
Not Yet Recruiting	Comparison of Effectiveness and Safety of Triple Combination Cream of Fucinolone Acetonide 0.01%, Hydroquinone NCT06780644	Indonesia University	N/A
Completed	Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonid NCT07345507	Jinnah Postgraduate Medical Centre	N/A
Not Yet Recruiting	Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermat NCT06763367	Nanjing First Hospital, Nanjing Medical University	N/A
Active Not Recruiting	Treatment and Prevention of Melasma Relapses by Using 1064nm 650 Microsecond Laser NCT06644157	Centre Hospitalier Universitaire de Nice	N/A
Completed	Comparison of Intradermal Microinjections of Tanexamic Acid and Oral Tranexamic Acid in the Management of Mela NCT07280234	Hayat Abad Medical Complex, Peshawar	EARLY_Phase 1
Active Not Recruiting	Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma NCT07034560	Thammasat University	Phase 4
Completed	Efficacy of Radiofrequency Micro Needling for the Treatment of Melasma in Skin of Color. NCT06616311	The Cleveland Clinic	N/A
Completed	Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Melasma NCT06677931	Fujian Medical University Union Hospital	N/A
Not Yet Recruiting	Anti-pigmenting Effect of a Routine of Facial Products in Subjects With Melasma NCT06516224	Cosmetique Active International	N/A
Recruiting	Randomized Study Using SM-030 Gel for Adults With Melasma NCT06454747	DermBiont, Inc.	Phase 2
Recruiting	Development of Products Based on Secretom From Stem Cell Conditioned Medium for Melasma Therapy NCT06516419	Dr.dr.Irma Bernadette, SpKK (K)	N/A
Unknown	Curcuma Xanthorriza Roxb. 10% Cream for Melasma NCT06153134	Universitas Padjadjaran	EARLY_Phase 1
Unknown	Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma. NCT05911698	Khadija Qenawi	N/A
Unknown	Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal Melasma NCT06278948	Cosmetique Active International	N/A
Unknown	Effectiveness and Safety of Pigment Solution Program (PSP) as Adjuvant Therapy in Melasma NCT06174545	Dr.dr.Irma Bernadette, SpKK (K)	N/A
Completed	EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA NCT06787846	Cosmetique Active International	N/A
Completed	Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split- NCT06957834	National Skin Centre	Phase 2
Recruiting	The Use of Image-Based Computer Gradings in the Analysis of Acne, Rosacea, Melasma, and Seborrheic Dermatitis NCT05942248	Integrative Skin Science and Research	N/A
Unknown	Tranexamic Acid With Microneedling in Melasma NCT05909072	Zagazig University	Phase 2
Unknown	The Effectiveness of 3% Topical Tranexamic Acid Compared to 4% Topical Hydroquinone as Therapy of Melasma NCT06010810	Indonesia University	Phase 3
Recruiting	Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma NCT06415435	Benev Company, Inc.	N/A
Terminated	Treatment of Melasma With Yellow Light Compared to Tranexamic Acid NCT05326997	University of Nove de Julho	N/A
Completed	The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R Ant NCT06313307	Second Affiliated Hospital of Xi'an Jiaotong University	N/A
Unknown	Oral Isotretinoin in Melasma a Randomized Controlled Trial NCT06201624	Zagazig University	Phase 1
Completed	Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma NCT05884151	Combined Military Hospital Abbottabad	Phase 1
Completed	Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in M NCT05887219	Combined Military Hospital Abbottabad	Phase 1
Unknown	Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma NCT05656833	UnionDerm	N/A
Unknown	Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma. NCT06013540	Jinnah Postgraduate Medical Centre	Phase 2
Unknown	Efficacy of Intralesional PRP +/- Topical Silymarin in the Treatment of Melasma NCT05626881	Sohag University	N/A
Unknown	Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of Melasma NCT05099601	Assiut University	Phase 4
Recruiting	Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration NCT06221787	Fujian Medical University Union Hospital	N/A
Completed	Annurca Apple Peel Oleolite for the Treatment of Skin Hyperpigmentation NCT07040345	Ritamaria Di Lorenzo	N/A
Completed	Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma NCT05790577	Ishtiaq Ahmed	Phase 2
Completed	A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate M NCT05013801	Unilever R&D	N/A
Completed	Tissue-resident Memory T Cells Expression in Melasma NCT05698342	Universidad Autonoma de San Luis Potosí	—
Completed	Green Banana Peel Extract for Melasma Treatment NCT05031689	Universidade do Vale do Sapucai	Phase 1
Completed	Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma NCT05362500	Combined Military Hospital Abbottabad	Phase 1
Unknown	Trichloroacetic Acid (TCA) Combined With Microdermabrasion in Treatment of Melasma NCT04823520	Assiut University	Phase 4
Completed	Effectiveness and Safety of Intradermal Tranexamic Acid Injection as An Adjunctive Treatment for Melasma in Sk NCT05236569	Indonesia University	N/A
Completed	Photoaging Reversing After Picosecond Laser With DLA Assessed by Cellular Resolution OCT in Asian Patient With NCT04602819	China Medical University Hospital	N/A
Completed	Efficacy and Safety of 30% Salicylic Acid and 10% Nicotinamide Combined Therapy in Melasma NCT07062120	Second Affiliated Hospital of Xi'an Jiaotong University	N/A
Unknown	Evaluation of Laser and Tranexamic Acid in Treatment of Melasma NCT04599205	Assiut University	Phase 2 / Phase 3
Withdrawn	Tri-split Face Study of Skin Resurfacing Modalities for the Treatment of Melasma NCT02892071	SUZAN OBAGI	Phase 1
Unknown	Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared W NCT04597203	Mahidol University	N/A
Withdrawn	Spironolactone for the Treatment of Melasma NCT03953209	Medical University of South Carolina	Phase 1
Unknown	Efficacy of Red Light in the Treatment of Pigmentary Disorders NCT04308421	University of British Columbia	N/A
Unknown	Different Dermatological Approaches the Treatment of Melasma NCT03923062	Assiut University	Phase 4
Completed	Cysteamine Compared to Hydroquinone in Melasma NCT05969587	China Medical University Hospital	Phase 3
Completed	Study Evaluating the Efficacy of DOSE Formulations in Treating Melasma and Cutaneous Signs of Aging NCT04137263	Goldman, Butterwick, Fitzpatrick and Groff	N/A
Unknown	Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in Melasma NCT04765930	Cairo University	N/A
Completed	Comparative Study of mMASI Before and After Hyperthyroid Therapy in Hyperthyroid Subjects With Melasma NCT04346901	Dr.dr.Irma Bernadette, SpKK (K)	Phase 1
Completed	Comparison Between Free Thyroxine and Thyroid Stimulating Hormone Levels on Melasma Severity NCT04359719	Indonesia University	—
Completed	Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma NCT03982849	Islamabad Medical and Dental College	Phase 2
Completed	A Clinical Observation of 1064-nm Q-Switched Fractional Laser Combined With Oral Tranexamic Acid on Treating o NCT03963466	xjpfW	N/A
Completed	Study of the Influence of Blue Light Emitted by Computer / Television Screens on Melasma MELABLUE Study NCT03877445	Centre Hospitalier Universitaire de Nice	N/A
Completed	Oral Superoxide Dismutase (GLISODin) to Decrease Melasma Severity. NCT03878433	Centre Hospitalier Universitaire de Nice	N/A
Unknown	Tranexamic Acid vs. Combination With Fractional Carbon Dioxide Laser in Melasma NCT03899233	Cairo University	Phase 4
Unknown	USE THE SYSTEMIC METFORMIN IN MELASMA NCT03475524	Assiut University	Phase 4
Unknown	Efficacy of Melanostop Peeling for Improvement of Melasma NCT03826277	VIST - Faculty of Applied Sciences	N/A
Completed	Opsin Receptors in Melasma NCT04417348	Universidad Autonoma de San Luis Potosí	N/A
Unknown	Oral Tranexamic Acid and Laser for Treatment of Melasma NCT03686787	Laser and Skin Surgery Center of New York	Phase 4
Unknown	Oral and Topical Tranexamic Acid for the Treatment of Melasma NCT03585179	Centro Dermatológico Dr. Ladislao de la Pascua	Phase 3
Completed	Efficacy and Safety of PiQo4 Device for Treatment of Melasma NCT03565341	Focus Medical, LLC	N/A
Withdrawn	Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel NCT02812719	Boston Medical Center	EARLY_Phase 1
Unknown	Microneedle and Trichloroaceticacid in Treatment of Melasma NCT03472235	Assiut University	N/A
Unknown	Modified Jessner's Solution With Trichloroacetic Acid Versus Glycolic Acid With Trichloroacetic Acid NCT03153852	Assiut University	Phase 4
Active Not Recruiting	LaseMD System for the Treatment of Melasma NCT03456674	CynosureLutronic	N/A
Unknown	Platelet Rich Plasma in Treatment of Melasma NCT03308370	Assiut University	Phase 3
Terminated	Lutronic PicoPlus Exploratory Clinical Trial NCT03415685	CynosureLutronic	N/A
Completed	Efficacy of Platelet-rich Plasma in Treatment of Melasma NCT03674203	Instituto Mexicano del Seguro Social	Phase 2
Unknown	1064-nm Q-switched Nd:YAG Laser and Intradermal Tranexamic Acid for Melasma NCT03008655	Taipei Medical University WanFang Hospital	N/A
Completed	Treatment of Melasma Using Q-switched Nd: YAG Laser and Fractional CO2 Laser Separately and in Combination NCT03848013	Kasr El Aini Hospital	N/A
Completed	Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With NCT02977507	Allergan	N/A
Completed	A Comparative Study for Efficacy and Safety Between 4% Hydroquinone Cream With or Without Fractional Picosecon NCT03049059	Mae Fah Luang University Hospital	Phase 2
Completed	Topical Composition Therapy (2013-MCN-333) for the Treatment of Melasma NCT02730819	Mayo Clinic	Phase 2
Completed	Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma NCT03751163	Fakultas Kedokteran Universitas Indonesia	Phase 3
Completed	Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 59 NCT03040089	CynosureLutronic	N/A
Completed	A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin NCT02385994	Cutera Inc.	N/A
Completed	DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide. NCT03392623	Universidad Autonoma de San Luis Potosí	EARLY_Phase 1
Completed	A Study of the RevLite Laser System for the Treatment of Refractory Mixed Type Melasma NCT02110134	Cynosure, Inc.	N/A
Completed	Evaluation of an Herbal-Based De-Pigmenting System NCT02138539	Sadick Research Group	Phase 4
Completed	Inflammation in Melasma: Study of Its Infiltrate and the Expression of Acute and Chronic Mediators NCT01952379	Universidad Autonoma de San Luis Potosí	—
Completed	Combination Alexandrite Laser and Topical Therapy vs Topical Therapy Alone for Treatment of Melasma NCT02095756	Cynosure, Inc.	N/A
Completed	Prevention of Melasma Relapse During Summertime NCT02061839	Centre de Pharmacologie Clinique Applique a la Dermatologie	N/A
Completed	Ultraviolet and UV-Visible Light Photoprotection for the Treatment of Melasma NCT01695356	Universidad Autonoma de San Luis Potosí	Phase 4
Terminated	Revlite Laser System Compared to the Candela Alex TriVantage System Refractory Mixed Type Melasma NCT01745224	Cynosure, Inc.	N/A
Completed	Comparative Study of Dual Yellow Laser Versus Stabilized Kilnman Preparation in the Treatment of Melasma NCT01850186	Centre Hospitalier Universitaire de Nice	N/A
Unknown	Clinical Trial of Hydroquinone Versus Miconazol in Melasma NCT01661556	Universidad Autonoma de San Luis Potosí	Phase 4
Completed	Polypodium Leucotomos Extract for the Treatment of Melasma NCT01092884	University of Texas Southwestern Medical Center	N/A
Completed	Melanil in the Treatment of Melasma NCT01001624	Catalysis SL	Phase 3
Unknown	Azelaic Acid Iontophoresis Versus Topical Azelaic Acid Cream in the Treatment of Melasma NCT00848458	Medical University of Vienna	Phase 2 / Phase 3
Terminated	In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy NCT00771355	Massachusetts General Hospital	—
Suspended	Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma NCT00717652	Azidus Brasil	Phase 2 / Phase 3
Unknown	Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion NCT01136629	National University Hospital, Singapore	—
Completed	Oral Polypodium Leucotomos for Melasma NCT01162850	University of Miami	N/A
Completed	Fractional Photothermolysis for Treating Melasma NCT01245881	Laserklinik Karlsruhe	N/A
Completed	Treatment of Melasma With Jessner's Solution vs. Trichloroacetic Acid NCT00166192	Emory University	Phase 4
Terminated	Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Li NCT00669071	Galderma R&D	Phase 4
Completed	Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic NCT00616239	University of Texas Southwestern Medical Center	Phase 4
Completed	Study of Acid Peel and Laser for the Treatment of Melasma NCT00467233	Northwestern University	N/A
Completed	Study of Light Treatment and Laser Treatment for Melasma NCT00509977	Northwestern University	N/A
Completed	Comparison of Two Tri-Luma® Maintenance Regimens in the Treatment of Melasma NCT00500162	Galderma R&D	Phase 4
Completed	Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma NCT00472966	Galderma R&D	Phase 4
Completed	Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma NCT00469183	Galderma R&D	Phase 4