NCT01092884

Polypodium Leucotomos Extract for the Treatment of Melasma

Polypodium Leucotomos Extract as an Adjunct to Sunscreen for the Treatment of Melasma

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

We will assess whether oral supplementation with Polypodium leucotomos, a commercially marketed fern extract, improves facial melasma in Hispanic women with moderate to severe melasma. Subjects will be randomized to either Group 1, which will receive oral Polypodium leucotomos extract plus topical sunscreen, or Group 2, which will receive oral placebo plus topical sunscreen. The study will last 12 weeks, and we hypothesize that the Polypodium leucotomos group will have more improvement in their melasma compared to the placebo group.

Conditions

• Melasma

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Polypodium leucotomos extract	240 mg capsule of Polypodium leucotomos extract will be taken orally three times daily
OTHER	Placebo	This placebo capsule will be taken orally three times daily

Timeline

• Start date: 2010-03-01
• Primary completion: 2011-07-01
• Completion: 2012-07-01
• First posted: 2010-03-25
• Last updated: 2023-09-06