NCT06957834

Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study

Randomised Double-blinded Split-face Controlled Study to Evaluate the Effectiveness of Eflornithine Hydrochloride Cream Compared to Topical Hydroquinone 2% Cream for the Treatment of Melasma.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: National Skin Centre · Network
• Sex: All
• Age: 25 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if Eflornithine hydrochloride cream works to treat melasma in adults, in comparison to Hydroquinone cream. It will also learn about the safety of Eflornithine hydrochloride cream. The main questions it aims to answer are: * Does Eflornithine hydrochloride improve melasma assessment scores over a 3-month duration compared to Hydroquinone cream? * What side effects might patients get while using Eflornithine hydrochloride cream? Participants will: * Apply both Eflornithine hydrochloride and Hydroquinone creams on separate halves of their faces every day for 3 months. * Visit the clinic once at the 2-month mark and once at the 3-month mark for checkups and tests.

Conditions

• Melasma

Interventions

Type	Name	Description
DRUG	Eflornithine hydrochloride cream	Eflornithine hydrochloride cream at 11.5% applied twice daily
DRUG	Hydroquinone cream	Hydroquinone 2% cream, applied twice daily

Timeline

• Start date: 2023-06-06
• Primary completion: 2024-07-11
• Completion: 2024-07-11
• First posted: 2025-05-05
• Last updated: 2025-05-05

Locations

1 site across 1 country: Singapore