NCT03674203

Efficacy of Platelet-rich Plasma in Treatment of Melasma

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Instituto Mexicano del Seguro Social · Other Government
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The application of Platelet Rich Plasma (PRP) on three occasions with an interval of 15 days between each one, is related to a decrease in the intensity of the spots and improvement in the quality of the skin of patients with melasma.

Detailed description

832/5000 Objective: To evaluate the effect of PRP for Melasma treatment. Material and methods: Prospective cohort with therapeutic intervention. Patients, female, with melasma were included. Changes in the melanin concentration of the face (MASI), degree of satisfaction (MELASQOL) and histological changes were clinically evaluated. The Sp-MELASQOL questionnaire, Fitzpatrick and MASI scales were applied, and photographs were taken with ambient light and with Wood's light with the Janus-II General Model. The patients were evaluated and classified, before and after the treatment by means of dermatoscopy, which was performed using a dermatoscope with polarized light (DermLite DL3N®), which allows an increase from 6 to 400X. The dermatoscopy reported the findings of: Quantity, Density and Depth of melasma.

Conditions

• Melasma

Interventions

Type	Name	Description
BIOLOGICAL	Platelet-Rich Plasma	1 ml of PRP was distributed in the papillary dermis of the face, repeating the dose at 15 and 30 days.

Timeline

• Start date: 2017-05-01
• Primary completion: 2018-05-31
• Completion: 2018-07-31
• First posted: 2018-09-17
• Last updated: 2019-01-28

Locations

1 site across 1 country: Mexico