| Recruiting | Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD NCT06220474 | The University of Hong Kong | N/A |
| Completed | The Effect of Gland Expression on the Regeneration of Meibomian Gland NCT06163105 | Chulalongkorn University | N/A |
| Not Yet Recruiting | iTear Single-center, Open-label, Single-arm Study NCT06525961 | The University of Hong Kong | Phase 4 |
| Completed | Preoperative iLux on Cataract Surgery Derived Dry Eye Disease Due to Meibomian Gland Dysfunction NCT06483750 | George Washington University | N/A |
| Recruiting | Photobiomodulation With REd vs BluE Light (REBEL) NCT06371300 | Aston University | N/A |
| Unknown | BroadBand Light for the Treatment of Dry Eye Disease NCT06174064 | University of Southern California | N/A |
| Completed | Mechanisms of Light-based Therapies for Dry Eye Disease NCT06004895 | Aston University | N/A |
| Active Not Recruiting | Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD NCT06064071 | Candela Corporation | N/A |
| Active Not Recruiting | Effect of an Exploratory Vehicle on Meibomian Gland Dysfunction in Patients With Demodex NCT06054217 | Tarsus Pharmaceuticals, Inc. | Phase 2 |
| Completed | Effect of Sunflower Lecithin Supplementation on Meibomian Gland Function in Adults With Dry Eye Disease NCT06058559 | George Washington University | N/A |
| Completed | Evaluation of Low-Level Light Therapy on Meibomian Glands Study NCT05859295 | University of Houston | N/A |
| Completed | A Modified Calculation Formula for Meibomian Gland Grading NCT06106737 | Zhongnan Hospital | — |
| Completed | The Impact of Dry Eye Syndrome on Metrics of Low Contrast Vision Before and After Meibomian Gland Expression NCT05713981 | University of the Incarnate Word | N/A |
| Completed | Comparison Between Continuous and Pulsed Oral Doxycycline Treatment Protocols for Refractory Meibomian Gland D NCT06520007 | University of Milan | — |
| Completed | Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction NCT04425551 | Naval Hospital, Athens | N/A |
| Unknown | Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed With Dry Eye Disease in NCT05598437 | Roweis adel youssef | — |
| Completed | Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD NCT05577910 | Chinese University of Hong Kong | N/A |
| Completed | to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysf NCT05162261 | Novoxel Ltd. | N/A |
| Unknown | To Evaluate the Efficacy of Diquafosol Sodium in the Treatment of MGD in Different Treatment Pattern NCT05383612 | Zhongshan Ophthalmic Center, Sun Yat-sen University | N/A |
| Completed | Pilot Study Comparing the Safety and Efficacy of Two Dosing Regimens of TP-03 for the Treatment of MGD NCT05454956 | Tarsus Pharmaceuticals, Inc. | Phase 2 |
| Unknown | The Efficacy and Safety of Topical Vitamin D Drop on Meibomian Gland Function in Patients With Meibomian Gland NCT05495958 | Shahid Beheshti University of Medical Sciences | Phase 2 / Phase 3 |
| Completed | Feasibility of IPL Combined With RF for Treatment of DED Due to MGD NCT05487547 | Lumenis Be Ltd. | N/A |
| Completed | Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associat NCT06745089 | National Yang Ming Chiao Tung University | N/A |
| Completed | Thermal Pulsation Versus Warm Compress Treatment for Meibomian Gland Dysfunction NCT06326931 | Jacksoneye | Phase 4 |
| Completed | Safety, Efficacy and Pharmacokinetics of CBT-008 in Patients With Meibomian Gland Dysfunction NCT05261386 | Cloudbreak Therapeutics, LLC | Phase 2 |
| Completed | Clinical Study Using Eye Lipid Mobilizer (ELM) With Heat and Vibration To Treat Evaporative Dry Eye Disease NCT06242860 | Eyedetec Medical, Inc. | N/A |
| Unknown | Evaluating Impact of Systane iLux on Dryness Symptoms and Wearing Time in Contact Lens Users NCT05306561 | Periman Eye Institute | N/A |
| Unknown | Evaluation of Neovis® Total Multi Versus Systane® Balance on Ocular Dryness Associated With Meibomian Gland Dy NCT05191771 | Horus Pharma | N/A |
| Completed | Safety of Tinted Soft Scleral Eye Shields When IPL is Applied on Eyelids NCT05168670 | Lumenis Be Ltd. | N/A |
| Unknown | Effectiveness and Safety of High Frequency Electrotherapy in Patients With Meibomian Gland Dysfunction NCT05165342 | Chulalongkorn University | N/A |
| Unknown | Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necro NCT05145959 | Massachusetts Eye and Ear Infirmary | N/A |
| Unknown | Efficacy and Safety of Topical Hydrocortisone on Signs and Symptoms of Dry Eye Associated to Meibomian Gland D NCT05159284 | Laboratorios Thea, Spain | Phase 4 |
| Completed | Evaluate the Safety and Effectiveness of The Tixel Fractional System in the Treatment of Meibomian Gland Disfu NCT04889950 | Novoxel Ltd. | N/A |
| Unknown | Intense Pulsed Light in Meibomian Gland Dysfunction NCT05089591 | Prim. Prof. Dr. Oliver Findl, MBA | N/A |
| Completed | Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry NCT05062564 | Azienda Ospedaliero-Universitaria Careggi | N/A |
| Completed | Safety, Efficacy and Pharmacokinetics of CBT-006 in Patients With Meibomian Gland Dysfunction NCT04884243 | Cloudbreak Therapeutics, LLC | Phase 2 |
| Suspended | Intense Regulated Pulsed Light Vs Standard of Care for the Treatment of Meibomian Gland Dysfunction NCT04920396 | Aston University | N/A |
| Completed | Short and Long-term Results of Skin Versus Skin Plus Orbicularis Resection Blepharoplasty NCT05528016 | Marmara University | N/A |
| Completed | Safety And Effectiveness Of The TearCare® System In The Treatment Of The Signs And Symptoms Of Dry Eye Disease NCT04795752 | Sight Sciences, Inc. | N/A |
| Unknown | Analysis of the Results of Intense Pulsed Light Treatment Previously to Laser Refractive Surgery NCT05139511 | Vissum, Instituto Oftalmológico de Alicante | N/A |
| Completed | Dextenza With ILUX for Treatment of MGD NCT04658927 | Warrenville Eyecare | Phase 4 |
| Unknown | Intense Pulsed Light Therapy in Meibomian Gland Dysfunction NCT04904874 | Dar Al Shifa Hospital | N/A |
| Unknown | Evaluation of the Efficacy of Intense Pulse Light Combined With Lipiflow in the Treatment of Meibomian Gland D NCT04633798 | Aier School of Ophthalmology, Central South University | N/A |
| Unknown | The Effect of Warm Compress Therapy Using the TearRestore Eyelid Warming Mask on Meibomian Gland Function NCT04309799 | University of Colorado, Denver | N/A |
| Completed | iLux Treatment for Meibomian Gland Dysfunction NCT06278584 | Clínica de Oftalmología de Cali S.A | N/A |
| Unknown | Morphological Analysis of Meibomian Glands NCT04052841 | Zhongshan Ophthalmic Center, Sun Yat-sen University | N/A |
| Completed | Evaluation of the LipiFlow System With a New Activator NCT04500821 | Johnson & Johnson Surgical Vision, Inc. | N/A |
| Completed | The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients NCT05028491 | Wenzhou Medical University | — |
| Completed | Evaluation of AZR-MD-001 in Patients With Meibomian Gland Dysfunction (MGD) NCT04391959 | Azura Ophthalmics | Phase 2 |
| Completed | Methods to Enhance AZR-MD-001 for Meibomian Gland Dysfunction (MGD) NCT04314362 | Azura Ophthalmics | Phase 2 / Phase 3 |
| Unknown | Effect of Eye Make up on Ocular Surface NCT04478955 | Erol Olcok Corum Training and Research Hospital | — |
| Completed | Evaluation of AXR-270 for the Treatment of Posterior Blepharitis Associated With Meibomian Gland Dysfunction NCT04469998 | AxeroVision, Inc. | Phase 2 |
| Unknown | Facial Demodicosis and Ocular Demodicosis NCT04377841 | National Taiwan University Hospital | — |
| Completed | Clinical Effect of MiboFlo in Dry Eye Patients NCT04310969 | Beijing Tongren Hospital | N/A |
| Completed | Meibomian Gland Dysfunction Treatment NCT04229888 | Indiana University | N/A |
| Unknown | Stability of Biometry in Meibomian Gland Dysfunction NCT04322656 | Vienna Institute for Research in Ocular Surgery | N/A |
| Completed | Lipiflow vs iLux Patient Acceptance and Comfort Study NCT04454983 | Epstein, Arthur B., OD, FAAO | N/A |
| Unknown | Refractory Meibomian Gland Dysfunction and Plasma Jet NCT04608942 | Federal University of São Paulo | N/A |
| Completed | Intense Pulsed Light in Meibomian Gland Dysfunctions NCT04147962 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Recruiting | Efficacy and Safety of Thermic Devices in the Treatment of Meibomian Gland Dysfunction NCT03767530 | Universidad Autonoma de Nuevo Leon | N/A |
| Completed | Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multic NCT03956225 | Alcon Research | N/A |
| Completed | Meibomian Gland Dysfunction Management With ZEST Protocol NCT03968731 | University of the Incarnate Word | N/A |
| Completed | Effects and Prognostic Factors of Intensive Pulse Light Treatment for Meibomian Gland Dysfunction NCT03950115 | Samsung Medical Center | N/A |
| Completed | Study to Evaluate the Safety and Efficacy of Minocycline Ointment in Subjects With Inflamed Meibomian Gland Dy NCT03888378 | Hovione Scientia Limited | Phase 2 |
| Unknown | Clinical Efficacy of Hormone Replacement Therapy in Treating Perimenopausal Women With MGD NCT04962386 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | TearCare System to Treat Dry Eye Disease NCT03857919 | Sight Sciences, Inc. | N/A |
| Withdrawn | Efficacy and Safety of Meibomian Gland Dysfunction and Dry Eye With an LED Blue Treatment Device NCT03788486 | Toyos Clinic | N/A |
| Completed | A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye NCT03652051 | Azura Ophthalmics | Phase 2 |
| Unknown | DRy Eye Outcome and Prescription Study NCT03652415 | Guy's and St Thomas' NHS Foundation Trust | — |
| Completed | Manuka Honey Eye Drops VS Conventional Treatment of Meibomian Gland Dysfunction Related Dry Eye Disease NCT04457648 | Chinese University of Hong Kong | Phase 4 |
| Completed | IPL and MGX Versus MGX Alone in the Treatment of Dry Eye Disease Secondary to MGD NCT03265652 | Lumenis Be Ltd. | N/A |
| Active Not Recruiting | Meibomian Gland Dysfunction Management NCT03652337 | University of the Incarnate Word | N/A |
| Completed | Clinical, Meibographic and Interferometric Evaluation of Phlyctenular Keratitis in Children - MEIBO-ROSACEE NCT03479853 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Unknown | Investigating the Effect of At Home Thermal Therapy on Dry Eye Patients With Meibomian Gland Dysfunction NCT03291704 | UMay Care Inc. | N/A |
| Unknown | Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction NCT03434106 | LanZhou University | N/A |
| Completed | Effect of Topical Azithromycin on Tear Film Thickness in Patients With Meibomian Gland Dysfunction NCT03162497 | Medical University of Vienna | Phase 4 |
| Completed | Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye NCT03012698 | Epitech Mag Ltd. | N/A |
| Completed | Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction NCT03318874 | Oslo University Hospital | Phase 4 |
| Completed | Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye NCT03617315 | University of Seville | N/A |
| Withdrawn | Effect of Cataract Hyperemulsification Surgery on Meibomian Gland Morphology and Function NCT04667871 | Yune Zhao | — |
| Unknown | Evaluation of Ocular Surface Changes Following RF Electrocoagulation Treatment of the Periorbital Region NCT03280069 | Ophthalmic Consultants of Long Island | — |
| Completed | Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures NCT03461978 | Medical University of Vienna | N/A |
| Unknown | Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ? NCT03060005 | Tung Wah Hospital | N/A |
| Unknown | Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blephariti NCT03422146 | Ottawa Hospital Research Institute | N/A |
| Completed | Comparison Between iLux™ and LipiFlow® in the Treatment of Meibomian Gland Dysfunction NCT03055832 | Tear Film Innovations, Inc. | N/A |
| Withdrawn | Effect of Meibomian Gland Probing on Ocular Surface in Ocular Rosacea NCT02735681 | University of Arkansas | N/A |
| Completed | Effect of HMG-CoA Reductase Inhibitors on the Meibomian Gland Morphology in Patients With Meibomitis NCT04085016 | National Taiwan University Hospital | — |
| Unknown | Fingerprick Autologous Blood (FAB) in Mebomian Gland Dysfunction (MGD) NCT02943382 | Bedford Hospital NHS Trust | N/A |
| Withdrawn | Lipiflow Versus Warm Compresses in Parkinson's Disease NCT02894658 | Wake Forest University Health Sciences | N/A |
| Completed | Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Co NCT02848222 | University of Alabama at Birmingham | N/A |
| Completed | Tear Film Innovations iLux Safety Study NCT03055897 | Tear Film Innovations, Inc. | N/A |
| Terminated | Brimonidine Eye Drops for Treatment of Ocular Graft-vs-Host Disease (oGVHD) NCT02975557 | Sandeep Jain, MD | Phase 1 / Phase 2 |
| Unknown | The Correlation Between the Thickness of Lipid Layer and the Meibomian Gland Dysfunction NCT03337295 | Wenzhou Medical University | — |
| Terminated | Fast Infrared Meibography (Photography) NCT02596919 | Queen Victoria Hospital NHS Foundation Trust | N/A |
| Completed | Comparison of BlephEx to MiBoflo as Treatment Options for Blepharitis NCT02952079 | University of the Incarnate Word | N/A |
| Completed | Changes of Tear-film Lipid Layer Thickness and Ocular Aberration After Treatment of Meibomian Gland Dysfunctio NCT02618304 | Yonsei University | N/A |
| Completed | Intraductal Meibomian Gland Probing Trial NCT02256969 | Joseph B. Ciolino, MD | Phase 4 |
| Completed | The Effect of Tear Supplements on Contact Lens Comfort NCT02956083 | University of the Incarnate Word | N/A |
| Completed | Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers NCT02102464 | TearScience, Inc. | N/A |
| Withdrawn | Efficacy of Pulsed Light Therapy for Meibomian Gland Dysfunction and Dry Eye Syndrome NCT01917539 | University of Miami | N/A |
| Completed | EyeBag Effectiveness in Meibomian Gland Dysfunction NCT01870180 | Aston University | N/A |
| Completed | Contact Lens Comfort Relative to Meibomian Gland Status NCT01819194 | Johnson & Johnson Vision Care, Inc. | N/A |
| Withdrawn | Study to Determine the Effect of Azasite on Corneal Surface Irregularity NCT01797107 | Philadelphia Eye Associates | Phase 2 |
| Completed | Evaluation of Dry Eye and Meibomian Gland Dysfunction After Cataract Surgery NCT01942642 | Yonsei University | — |
| Completed | A Study of AGN-195263 for the Treatment of Meibomian Gland Dysfunction NCT01633788 | Allergan | Phase 2 |
| Completed | Comparison of Lipiflow®-Treatment and a Standard Lid Hygiene Regime NCT01769105 | Heinrich-Heine University, Duesseldorf | N/A |
| Completed | Management of Eyelid Disorders by Ophthalmologists in Usual Medical Practice NCT01552174 | Laboratoires Thea | — |
| Completed | Randomized Controlled Trial of Long-term Treatment Effectiveness for Meibomian Gland Dysfunction (MGD) and Dry NCT01521507 | TearScience, Inc. | N/A |
| Completed | Eyelid Warming Technology for Meibomian Gland Dysfunction NCT01448369 | Singapore National Eye Centre | N/A |
| Completed | Effects of Minocycline on Cytokine Levels in Severe Meibomian Gland Dysfunction NCT01600625 | Yonsei University | N/A |
| Completed | Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis NCT01456780 | Massachusetts Eye and Ear Infirmary | Phase 4 |
| Completed | Meibography and Tear Scan Using the Oculus Keratograph 4 NCT01382108 | University of Waterloo | — |
| Completed | The Efficacy of an Ocular Emulsion in Meibomian Gland Dysfunction NCT01207752 | Southern California College of Optometry at Marshall B. Ketchum University | N/A |
| Completed | Evaluation of FID 114657 in Dry Eye Subjects NCT01079858 | Alcon Research | N/A |
| Completed | Safety and Efficacy Study of a Testosterone Eye Drop for the Treatment of Meibomian Gland Dysfunction NCT00755183 | ORA, Inc. | Phase 2 |
| Completed | Efficacy of 0.05 % Cyclosporine Ophthalmic Emulsion Compare With Tear in Meibomian Gland Dysfunction NCT00705510 | Mahidol University | Phase 4 |