NCT04962386

Clinical Efficacy of Hormone Replacement Therapy in Treating Perimenopausal Women With MGD

Clinical Efficacy of Hormone Replacement Therapy in Treating Perimenopausal Women With Meibomian Gland Dysfunction

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: Female
• Age: 25 Years – 45 Years
• Healthy volunteers: —

Summary

This project aims to evaluate the possible relationship between MGD and HRT in perimenopausal women

Detailed description

This project aims to: 1. Evaluate the possible relationship between MGD and HRT in perimenopausal women; 2. To explore the mechanism of HRT treatment on MGD through clinical trials;3. Optimize treatment methods by exploring the mechanism, and develop more personalized and systematic treatment plans for MDG patients in the perimenopausal period.

Conditions

• Meibomian Gland Dysfunction

Interventions

Type	Name	Description
DRUG	Hormone replacement therapy	HRT women were treated with an estrogen-progesterone combination therapy packaged with estradiol tablets/estradiol and dynamic progesterone (Abbott Health Products BV, Weesp, the Netherlands).Take this medicine once a day.A course of treatment was defined as 28 days of continuous treatment.One white tablet containing 1mg of estradiol was taken daily for the first 14 days and one gray tablet containing 1mg of estradiol and 10 mg of dynamic progesterone was taken daily for the remaining 14 days.

Timeline

• Start date: 2019-03-06
• Primary completion: 2022-03-06
• Completion: 2022-03-06
• First posted: 2021-07-15
• Last updated: 2021-09-13

Locations

2 sites across 1 country: China